{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:43:38Z","timestamp":1788633818473,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The prefrontal\u2013cingulate\u2013thalamic areas are associated with ejaculation control. Functional\u00a0abnormalities of these areas and decreased grey matter volume (GMV) in the subcortical areas have been confirmed in premature ejaculation (PE) patients. However, no study has explored the corresponding GMV\u00a0changes in the prefrontal\u2013cingulate\u2013thalamic areas, which are considered as the important basis for functional\u00a0abnormalities. This study aimed to investigated whether PE patients exhibited impaired GMV in the brain, especially the prefrontal\u2013cingulate\u2013thalamic areas, and whether these structural deficits were associated with declined ejaculatory control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>T1\u2010weighted structural magnetic resonance imaging (MRI) data were acquired from 50 lifelong PE patients and 50 age\u2010, and education\u2010matched healthy controls (HCs). The PE diagnostic tool (PEDT) was applied to assess the subjective symptoms of PE. Based on the method of voxel\u2010based morphometry (VBM), GMV were measured and compared between groups. In addition, the correlations between GMV of brain regions showed differences between groups and PEDT scores were evaluated in the patient group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PE patients showed decreased GMV in the right dorsolateral superior frontal gyrus (clusters\u00a0=\u00a013, peak <jats:italic>T<\/jats:italic>\u2010values\u00a0=\u00a0\u22124.30) and left thalamus (clusters\u00a0=\u00a047, <jats:italic>T<\/jats:italic>\u00a0=\u00a0\u22124.33), and increased GMV in the left middle cingulate gyrus (clusters\u00a0=\u00a012, <jats:italic>T<\/jats:italic>\u00a0=\u00a04.02) when compared with HCs. In the patient group, GMV of the left thalamus were negatively associated with PEDT scores (<jats:italic>r\u00a0<\/jats:italic>=\u00a0\u22120.35; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.01). Receiver operating characteristic (ROC) analysis showed that GMV of the right dorsolateral superior frontal gyrus (AUC\u00a0=\u00a00.71, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01, sensitivity\u00a0=\u00a060%, specificity\u00a0=\u00a078%), left thalamus (AUC\u00a0=\u00a00.72, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01, sensitivity\u00a0=\u00a092%, specificity\u00a0=\u00a046%) and middle cingulate gyrus (AUC\u00a0=\u00a00.69, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01, sensitivity\u00a0=\u00a050%, specificity\u00a0=\u00a090%), and the combined model (AUC\u00a0=\u00a00.84, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01, sensitivity\u00a0=\u00a078%, specificity\u00a0=\u00a080%) all had the\u00a0ability to distinguish PE patients from HCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Disturbances in GMV were revealed in the prefrontal\u2013cingulate\u2013thalamic areas of PE patients. The findings implied that decreased GMV in the dorsolateral prefrontal cortex and thalamus might be associated with the central pathological neural mechanism underlying the declined ejaculatory control while increased GMV in the middle cingulate gyrus might be the compensatory mechanism underlying PE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13547","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T11:50:42Z","timestamp":1698666642000},"page":"841-849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Decreased grey matter volume in dorsolateral prefrontal cortex and thalamus accompanied by compensatory increases in middle cingulate gyrus of premature ejaculation patients"],"prefix":"10.1111","volume":"12","author":[{"given":"Songzhan","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Andrology The Third Affiliated Hospital of Zhengzhou University  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