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Male obesity has been shown to affect fertility through various mechanisms, including changes in semen quality, difficulty with natural conception, and worsened assisted reproductive technology outcomes. The evidence regarding the impact of male obesity on success of sperm retrieval is conflicting, but all aforementioned adverse effects may be modifiable with weight loss. Moreover, paternal obesity may influence atypical offspring outcomes, such as placental abnormalities and disruptions in fetal development, which may be moderated by epigenetic pathways. Further research is needed to fully understand the complex relationships and underlying mechanisms involved. Gaining more insight into the impact of male obesity on fertility and offspring outcomes can aid in the development of targeted interventions to improve family planning and the health of future generations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13552","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T11:08:45Z","timestamp":1698318525000},"page":"64-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Male obesity: Associated effects on fertility and the outcomes of offspring"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1555-3236","authenticated-orcid":false,"given":"Greeshma","family":"Venigalla","sequence":"first","affiliation":[{"name":"Desai Sethi Urology Institute Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Ila","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Dornbush","sequence":"additional","affiliation":[{"name":"Medical College of Georgia AU\/UGA Medical Partnership  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Department of Urology NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Loloi","sequence":"additional","affiliation":[{"name":"Department of Urology Montefiore Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology URI, IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"University Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Miller","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1387-7904","authenticated-orcid":false,"given":"Ranjith","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.Obesity. 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