{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T20:39:05Z","timestamp":1770496745813,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whether the observed lower total testosterone (tT) levels in male patients with COVID\u201019 are caused by a direct impact of SARS\u2010CoV\u20102 infection or are collateral phenomena shared by other systemic inflammatory conditions has not yet been clarified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the independent role of COVID\u201019 in reducing circulating tT levels in men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We compared demographic, clinical, and hormonal values of patients with laboratory confirmed COVID\u201019 admitted during the first wave of the pandemic with a cohort of consecutive male patients admitted to the intensive care unit (ICU) of the same academic center because of severe acute respiratory distress syndrome (ARDS) but without SARS\u2010CoV\u20102 infection and no previous history of COVID\u201019. Linear regression model tested the independent impact of COVID\u201019 on circulating tT levels. Logistic regression model was used to test predictors of death in the entire cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 286 patients with COVID\u201019, 70 men had been admitted to the ICU ( =\u00a0cases) and were compared to 79 patients equally admitted to ICU because of severe ARDS but negative for SARS\u2010CoV\u20102 infection and without previous history of COVID\u201019 ( =\u00a0controls). Controls were further grouped into noninfective (<jats:italic>n<\/jats:italic>\u00a0=\u00a049) and infective\u2010ARDS (<jats:italic>n<\/jats:italic>\u00a0=\u00a030) patients. At baseline, controls were older (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) and had more comorbidities (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Overall, cases admitted to ICU had significantly lower circulating tT levels compared to controls (0.9\u00a0nmol\/L vs. 2.1\u00a0nmol\/L; vs. 1.2\u00a0nmol\/L; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03). At linear regression, being negative for COVID\u201019 was associated with higher tT levels (Coeff: 2.13; 95% confidence interval \u2010 CI 0.71\u20103.56; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004) after adjusting for age, BMI, comorbidities and IL\u20106 levels. Only age and IL\u20106 levels emerged to be associated with higher risk of death regardless of COVID\u201019 status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This case\u2010control ex post facto study showed lower tT levels in men with COVID\u201019 compared to those without COVID\u201019 despite both groups have been equally admitted to ICU for severe ARDS, thus suggesting a possible direct impact of SARS\u2010CoV\u20102 infection toward circulating tT levels and a consequent more severe clinical outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13558","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T10:15:26Z","timestamp":1700648126000},"page":"1137-1147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is SARS\u2010CoV\u20102\u2010induced disease a decisive factor influencing testosterone in males? 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