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Serving as the control panel for sensing extracellular stimuli, G\u2010protein\u2010coupled receptors recognise various ligands, including light, temperature, odours, pheromones, hormones, neurotransmitters, chemokines, etc. Most recently, G\u2010protein\u2010coupled receptors residing in spermatozoa have been found to be indispensable for sperm function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Here, we have summarised cutting\u2010edge findings on the functional mechanisms of G\u2010protein\u2010coupled receptors that are known to be associated with sperm functions and the activation of their downstream effectors, providing new insights into the roles of G\u2010protein\u2010coupled receptors in sperm physiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Emerging studies hint that alterations in G\u2010protein\u2010coupled receptors could affect sperm function, implicating their role in fertility, but solid evidence needs to be continuing excavated with various means. Several members of the G\u2010protein\u2010coupled receptor superfamily, including olfactory receptors, opsins, orphan G\u2010protein\u2010coupled receptors, CXC chemokine receptor 4, CC chemokine receptor 5 and CC chemokine receptor 6 as well as their downstream effector \u03b2\u2010arrestins, etc., were suggested to be essential for sperm motility, capacitation, thermotaxis, chemotaxis, Ca<jats:sup>2+<\/jats:sup> influx through CatSper channel and fertilisation capacity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present review provides a comprehensive overview of studies describing G\u2010protein\u2010coupled receptors and their potential action in sperm function. We also present a critical discussion of these issues, and a possible framework for future investigations on the diverse ligands, biological functions and cell signalling of G\u2010protein\u2010coupled receptors in spermatozoa. Here, the G\u2010protein\u2010coupled receptors and their related G proteins that specifically were identified in spermatozoa were summarised, and provided references valuable for further illumination, despite the evidence that is not overwhelming in most cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13593","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T06:19:15Z","timestamp":1705385955000},"page":"1253-1271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["New insights into sperm physiology regulation: Enlightenment from G\u2010protein\u2010coupled receptors"],"prefix":"10.1111","volume":"12","author":[{"given":"Pengyuan","family":"Dai","sequence":"first","affiliation":[{"name":"Institute of Reproductive Medicine Medical School of Nantong University  Nantong PR 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