{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:45:04Z","timestamp":1768002304511,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical palpable varicocoeles in conjunction with isolated teratozoospermia are rarely observed. Therefore, the effects of varicocoelectomy on sperm morphology are not clear. The aim of this meta\u2010analysis is to compile studies that assess the effectiveness of varicocoelectomy in isolated teratozoospermia to reach a more consistent and reliable conclusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material\u2010Methods<\/jats:title><jats:p>The present meta\u2010analysis was registered to PROSPERO (CRD42023467933). We utilized the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses) guideline to report the outcomes. Articles published before 1 October 2023 were included in the study. The search terms used were teratozoospermia, isolated teratozoospermia, varicocoelectomy for isolated teratozoospermia, and semen analysis after varicocoelectomy in isolated teratozoospermia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 1,013 studies in full publications or abstracts using the methodology and the search terms. Five studies were included for systematic review, while four were included for meta\u2010analysis. The five studies (10\u201314) included 348 patients aged 18\u201344 years. The pooled analysis revealed a significant improvement in sperm morphology in isolated teratozoospermia patients undergoing varicocoelectomy (<jats:italic>Q<\/jats:italic>\u00a0=\u00a0199.42, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a098.49%). The pooled analysis revealed no significant improvement in sperm concentration in isolated teratozoospermia patients undergoing varicocoelectomy (<jats:italic>Q<\/jats:italic>\u00a0=\u00a05.69, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.058; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a064.85%). Three of the examined studies provided information regarding pregnancy rate and it was high in all studies. According to the Newcastle\u2013Ottowa scale (NOS) assessment, the total quality score of all studies was 7. The funnel plot test demonstrated a visible asymmetry, and Begg and Mazumdar's rank correlation test confirmed the publication bias (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Varicocoelectomy can be an effective and reliable treatment option in patients with isolated morphology abnormalities and clinically palpable varicocoele.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta\u2010analysis reported that varicocoelectomy may increase pregnancy rates by improving semen parameters in infertile men with isolated teratozoospermia, although this conclusion requires further evidence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13602","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T15:45:37Z","timestamp":1707752737000},"page":"1642-1650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Is varicocoelectomy indicated in infertile men with isolated teratozoospermia? a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9115-7203","authenticated-orcid":false,"given":"Murat","family":"Dursun","sequence":"first","affiliation":[{"name":"Department of Urology \u0130stanbul Faculty of Medicine \u0130stanbul University  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7459-584X","authenticated-orcid":false,"given":"H\u00fcseyin","family":"Be\u015firo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Urology \u0130stanbul University\u2010Cerrahpa\u015fa, Faculty of Medicine  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Re\u015fat","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Urology \u0130stanbul Faculty of Medicine \u0130stanbul University  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turgay","family":"Ka\u00e7an","sequence":"additional","affiliation":[{"name":"Section of Andrology Department of Urology \u0130stanbul Faculty of Medicine \u0130stanbul University  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Halil","family":"Sevin\u00e7","sequence":"additional","affiliation":[{"name":"Section of Andrology Department of Urology \u0130stanbul Faculty of Medicine \u0130stanbul University  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ate\u015f","family":"Kad\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Section of Andrology Department of Urology \u0130stanbul Faculty of Medicine \u0130stanbul University  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.06.044"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2012.05.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00353.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2017.98"},{"key":"e_1_2_8_6_1","unstructured":"SaloniaA BettocchiC CapogrossoP et\u00a0al.European Association of Urology Guidelines on sexual and reproductive health.Presented at the EAU Annual Congress Milan.Arnhem The Netherlands:EAU Guidelines Office;2023. 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