{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:29:27Z","timestamp":1789086567113,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Primary intravaginal anejaculation (PIAJ) is a relatively uncommon male sexual dysfunction characterized by an inability to achieve intravaginal ejaculation during all sexual\u00a0intercourse. Effective treatment options\u00a0for this condition are lacking.\u00a0We aimed to explore the clinical effect of the sexual therapy combined with vacuum negative pressure hydropneumatic\/pneumatic bubble massage (VNPHP\/PBM) on primary intravaginal anejaculation, and its possible mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 95 PIAJ patients were randomly divided into three groups, including group A with 32 patients treated with the sexual therapy combined with VNPHP\/PBM, group B with 32 patients treated with the sexual therapy and group C with 31 patients treated with VNPHP\/PBM. The efficacy of therapeutic regimes, latency of the somatosensory evoked potentials of dorsal nerve (DNSEP), glans penis (GPSEP) and penile shaft sensory threshold (PSST), measures of sexual behavior of patients, as well as the self\u2010rating anxiety scale (SAS) sores of patients and their partners, were compared before and after treatment among\u00a0three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total effective rate of group A (84.38%) was higher than those of groups B and C (53.13% and 41.94%), however, no differences were found between groups B and C. The ratios of patients and their partners with anxiety, frequency of observing erotic films of patients, ratios of patients with special self\u2010masturbation and frequency of masturbation decreased significantly in the three groups after the treatment. The decrease\u00a0in the ratios of patients and their partners with anxiety, frequency of observing erotic films of patients in groups A and B were higher than those of group C, however, no differences were identified between groups A and B. The decrease\u00a0in the ratios of patients with special self\u2010masturbation and frequency of masturbation in group A were higher than those of group B, however, no differences were found between groups A and C, B and C. There were no differences in the latency of DNSEP, GPSEP, and PSST among the three groups before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The sexual therapy combined with VNPHP\/PBM has good therapeutic effects on PIAJ, which might be achieved by reducing the anxiety\u00a0level of patients and their partners,\u00a0improving sexual behavioral patterns, rather than increasing the sensitivity of penis including dorsal nerve and glans penis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13622","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T05:05:14Z","timestamp":1709615114000},"page":"1822-1829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Application of the sexual therapy combined with vacuum negative pressure hydropneumatic\/pneumatic bubble massage in primary intravaginal anejaculation"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2252-6064","authenticated-orcid":false,"given":"Qingqiang","family":"Gao","sequence":"first","affiliation":[{"name":"Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9786-2585","authenticated-orcid":false,"given":"Jianhuai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Andrology Jiangsu Province Hospital\u00a0of Chinese Medicine Affiliated Hospital of Nanjing University\u00a0of\u00a0Chinese\u00a0Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Andrology Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing 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