{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:10:36Z","timestamp":1792271436453,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Due to global warming seasonal heat stress is an increasing problem in temperate zones. Heat stress not only decreases fertility in females, but can also be detrimental to male fertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We studied the effects of natural summer heat stress during spermatogenesis in Holstein bulls on semen quality parameters and on fertilization performance in vitro and possible intergenerational transmission of effects on the next male generation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Semen samples from young Holstein breeding bulls, referred to as F0 founders during this study, were collected during summer (F0 \u201csummer\u201d semen) and the following winter (F0 \u201cwinter\u201d semen). Parameters such as ejaculate volume, sperm density, motility, thermoresistance, and in vitro blastocyst rates from these F0 semen samples were determined. In addition, after generation of offspring by artificial insemination, semen samples from F1 male offspring were collected and tested for the same quality and performance parameters to capture intergenerational effects. F1 bulls were raised together under identical conditions and semen was collected at about 1 year after birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The data showed that in vitro blastocyst rates of F0 \u201csummer\u201d semen samples were lower compared with \u201cwinter\u201d semen, whereas blastocyst rates of F1 semen samples did not show significant differences. However, whereas F0 semen samples did not indicate significantly different quality parameters we found that motility of F1 semen samples showed significant differences with higher values when collected from bulls generated with F0 \u201cwinter\u201d semen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusion<\/jats:title><jats:p>From our data, we conclude that (i) natural summer heat stress during spermatogenesis can affect in vitro fertility parameters and (ii) the observed effects on sperm motility of F1 semen samples suggest intergenerational paternal transmission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13627","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T21:24:00Z","timestamp":1710365040000},"page":"1897-1906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Summer heat during spermatogenesis reduces in vitro blastocyst rates and affects sperm quality of next generation bulls"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7374-4615","authenticated-orcid":false,"given":"Jens","family":"Vanselow","sequence":"first","affiliation":[{"name":"Research Institute for Farm Animal Biology (FBN)  Dummerstorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Wesenauer","sequence":"additional","affiliation":[{"name":"RinderAllianz GmbH  Woldegk Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Eggert","sequence":"additional","affiliation":[{"name":"Research Institute for Farm Animal Biology (FBN)  Dummerstorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpna","family":"Sharma","sequence":"additional","affiliation":[{"name":"Research Institute for Farm Animal Biology (FBN)  Dummerstorf 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