{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:39:24Z","timestamp":1788273564440,"version":"build-2803163510"},"reference-count":65,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>This study aimed to assess the protective ability of edaravone on testicular torsion\u2013detorsion injury in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen adult male Sprague\u2013Dawley rats were randomly divided into three groups: Sham group (control, <jats:italic>n<\/jats:italic>\u00a0=\u00a06); testicular torsion\/detorsion (T\/D group, <jats:italic>n<\/jats:italic>\u00a0=\u00a06) and T\/D+edaravone (T\/D+E group, <jats:italic>n<\/jats:italic>\u00a0=\u00a06). The spermatic cords of rats of the T\/D group and the T\/D+E group were rotated 720\u00b0 in a clockwise direction and maintained for 120\u00a0min in this torsion position. Around 90\u00a0min after the torsion, edaravone at a dose of 10\u00a0mg\/kg dissolved in saline was administered IP to the T\/D+E group. The testicle was counter\u2010rotated to its normal position to allow reperfusion for 4\u00a0h. Left testes of each animal were excised 240\u00a0min after beginning of reperfusion. Oxidative stress markers (TAS, TOS, SOD, and MDA) and apoptotic pathways (Caspase 3, Caspase 8, Caspase 9, Bcl\u20102, and Bax,) were assessed by ELISA methods. Also, testicles were subjected to the histopathologic and ultrasound examinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ultrasound imaging showed that edaravone reduced the surface area and increased vascularization in testicles with T\/D (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05, respectively). Edaravone pretreatment markedly decreased the levels of MDA, TOS, Bcl\u20102, Bax, Caspase 3, Caspase 8, and Caspase 9 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Also, it increased significantly TAS levels (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) and reduced insignificantly SOD activity. Histopathologic examinations demonstrated that edaravone significantly attenuated the histological damage caused by T\/D in testicles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Taken together, the findings indicate that pretreatment of edaravone has protective effect against testicular T\/D injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13628","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T11:30:37Z","timestamp":1710415837000},"page":"1918-1927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of edaravone on testicular torsion\u2013detorsion injury in rats"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5936-4210","authenticated-orcid":false,"given":"Ya\u015far","family":"\u015eahin","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Pharmacology and 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