{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:32:26Z","timestamp":1784010746242,"version":"3.55.0"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Genetic and environmental factors have been shown to contribute to the development of congenital heart disease (CHD). To date, the focus of scientific articles has primarily centered on genetics and maternal environmental factors, with comparatively less attention given to paternal risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aims to investigate the potential association between paternal pre\u2010conceptional physical activity levels (PA), along with paternal peri\u2010conceptional smoking and alcohol consumption, and the risk of CHD in offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>An observational case\u2013control study was conducted in Lebanon, with 279 participants, aiming to investigate potential risk factors for CHD. We included children with confirmed CHD, born between 2012 and 2022. Controls born in the same timeframe were selected randomly from the general population using online questionnaire forms. Mean age of children included was 6 years old (0\u201310). The pre\u2010conceptional PA was assessed using the Global Physical Activity Questionnaire validated in Arabic. In addition, paternal smoking, alcohol consumption, and maternal risk factors were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 128 CHD cases (45.9%) and their parents, as well as 151 healthy infants (54.1%) and their parents. There were no statistically significant variations in the alcohol consumption noted between the fathers in the case and control groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.18). The paternal involvement in recreational\u2010related PA during the peri\u2010conception period was associated with a reduced risk of the CHD development in offspring by 46.9% (OR\u00a0=\u00a00.531, 95% CI: 0.301\u20130.936, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.029). Additionally, increasing paternal total sitting time by 1 h above the average, which was approximately 260 min (4\u00a0h), increased the risk of CHD in offspring by 0.4% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). Moreover, paternal smoking exhibited an apparent association with a 56% increased risk of offspring developing CHD, notwithstanding that the confidence intervals included the null (OR\u00a0=\u00a01.56, 95% CI: 0.86\u20132.8, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.136).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and conclusion<\/jats:title><jats:p>This observational study is the first to report a potential association between paternal PA, and CHD in offspring. This study aligns with previous reports, advocating for the paternal engagement in PA and the adoption of healthy lifestyle habits, especially during the critical stages of conception. Such practices are strongly recommended to enhance fertility and promote optimal health for offspring. However, due to the subjectivity in reporting PA and lack of molecular proof, additional prospective and molecular studies are required to validate these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13639","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T06:35:11Z","timestamp":1712903711000},"page":"34-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Paternal peri\u2010conceptional physical activity and the risk of congenital heart disease in offspring: A case\u2013control study"],"prefix":"10.1111","volume":"13","author":[{"given":"Ornina","family":"Atieh","sequence":"first","affiliation":[{"name":"School of Medicine and Medical Sciences Holy Spirit University of Kaslik  Jounieh Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nohad Maria J.","family":"Azzi","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Sciences Holy Spirit University of Kaslik  Jounieh Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges J.","family":"Lteif","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Sciences Holy Spirit University of Kaslik  Jounieh Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninar A.","family":"Atieh","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Sciences Holy Spirit University of Kaslik  Jounieh Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadim Y.","family":"Germanos","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Sciences Holy Spirit University of Kaslik  Jounieh Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Grandjean","sequence":"additional","affiliation":[{"name":"Inserm, C3M, Team Control of Gene Expression (10) Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zalihe","family":"Yarkiner","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences and Humanities Faculty of Arts and Sciences Northern Cyprus via Mersin Cyprus International University  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakhia","family":"Saliba","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Hotel Dieu de France University Medical Center Saint Joseph University Alfred Naccache Boulevard  Achrafieh Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Claude Fadous","family":"Khalife","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Sciences Holy Spirit University of Kaslik  Jounieh Lebanon"},{"name":"Pediatrics Department Notre Dame des Secours University Hospital Center  Jbeil Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8800-2796","authenticated-orcid":false,"given":"Georges","family":"Raad","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Sciences Holy Spirit University of Kaslik  Jounieh Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Pediatric Atrial Septal Defects: Background Embryology Pathophysiology. 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