{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:06:53Z","timestamp":1781788013602,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2702701"],"award-info":[{"award-number":["2022YFC2702701"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001530"],"award-info":[{"award-number":["82001530"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971368"],"award-info":[{"award-number":["81971368"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171597"],"award-info":[{"award-number":["82171597"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pediatric inguinal hernia repair (IHR) is a common cause of obstructive azoospermia (OA). Yet, the surgical treatment for this kind of OA remains difficult with poor fertility outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the safety and effectiveness of totally extraperitoneal laparoscopy\u2010assisted microsurgical vasovasostomy (VV) in the treatment of OA caused by pediatric bilateral IHR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Totally, 37 patients with OA caused by pediatric bilateral IHR were enrolled in this study from March 2015 to December 2020 in Shanghai General Hospital. The clinical data and fertility outcomes were collected and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients enrolled had a history of bilateral IHR at the age of 1\u201310 years old. The mean age of patients was 27\u00a0\u00b1\u00a04.31 (range: 18\u201335) years. Totally extraperitoneal laparoscopy (TEP) was applied in 31 patients for the exploration and retrieval of pelvic vas deferens end, and 30 of them underwent microsurgical VV successfully. Among the six cases where TEP was not applied, five cases underwent microsurgical anastomosis. Intraoperative exploration revealed that the location of vas deferens injuries included scrotum (2.70%, 1\/37), inguinal canal (5.41%, 2\/37), pelvic cavity (78.37%, 29\/37), and multiple sites (13.51%, 5\/37). The mean operation time was 339\u00a0\u00b1\u00a096.73 min (range: 130\u2013510 min). There were no surgical complications. Thirty\u2010three cases were followed up for 5\u201348 months with four cases lost to follow\u2010up. The overall patency rate, pregnancy rate, and natural pregnancy rate were 75.86% (22\/29), 46.67% (14\/30), and 36.84% (7\/19, 3 patients without family planning), respectively. And seven couples conceived through the assisted reproductive technique, two of which using fresh sperm in the ejaculate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TEP laparoscopy\u2010assisted microscopic VV is an effective treatment for patients with OA caused by pediatric bilateral IHR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13677","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T08:51:23Z","timestamp":1719391883000},"page":"504-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Totally extraperitoneal laparoscopy\u2010assisted microsurgical vasovasostomy for the treatment of obstructive azoospermia caused by pediatric bilateral inguinal 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Urology Urologic Medical Center Shanghai Key Laboratory of Reproductive Medicine Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Andrology Center for Men's Health Department of ART Institute of Urology Urologic Medical Center Shanghai Key Laboratory of Reproductive Medicine Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chencheng","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Andrology Center for Men's Health Department of ART Institute of Urology Urologic Medical Center Shanghai Key Laboratory of Reproductive Medicine Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 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