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Among these, the rising incidence of testicular disorders emerges as a pivotal determinant of fertility issues. Current treatment challenges are underscored by the limitations of high\u2010dose and frequent drug administration, coupled with substantial side effects and irreversible trauma inflicted by surgical interventions on testicular tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>The formidable barrier posed by the blood\u2013testis barrier compounds the complexities of treating testicular diseases, presenting a significant therapeutic obstacle. The advent of nanocarriers, with their distinctive attributes, holds promise in overcoming this impediment. These nanocarriers exhibit exceptional biocompatibility, and membrane penetration capabilities, and can strategically target the blood\u2013testis barrier through surface ligand modification, thereby augmenting drug bioavailability and enhancing therapeutic efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and discussion<\/jats:title><jats:p>This review concentrates on the transformative potential of nanocarriers in the delivery of therapeutic agents to testicular tissue. By summarizing key applications, we illuminate the strides made in utilizing nanocarriers as a novel avenue to effectively treat testicular diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nanocarriers are critical in delivering therapeutic agents to testicular tissue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13729","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T14:06:13Z","timestamp":1723212373000},"page":"694-705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Engineered nanoparticles potentials in male reproduction"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8334-2177","authenticated-orcid":false,"given":"Feifei","family":"Zhao","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics The First Affiliated Hospital of 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