{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:53:33Z","timestamp":1790744013109,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obesity represents a risk in the development of metabolic and oxidative stress (OS), as well as in male infertility. There is still no pharmacological treatment for obesity\u2010induced male infertility, but the use of natural antioxidants has been proposed as a treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this work is to evaluate the effect of a whole tomato lipid extract on rats that decreased their fertility and spermatogenesis after being induced obese with a high carbohydrate diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>One hundred fourteen male Wistar rats of 12\u00a0weeks of age were used. Two groups were randomly formed non\u2010obese control group (C, <jats:italic>n<\/jats:italic>\u00a0=\u00a054) and obese group (Ob, <jats:italic>n<\/jats:italic>\u00a0=\u00a054) that received 30% w\/v sucrose solution for 3 months. Subsequently, the C and Ob group were divided into two groups: vehicle (C\u2010Vh and Ob\u2010Vh) that received corn oil as vehicle and tomato lipid extract (C\u2010Ex and Ob\u2010Ex) that received whole tomato lipid extract. The groups that received a hypercaloric diet had a gain in visceral and retroperitoneal adipose tissue, an increase in total cholesterol and triglyceride levels, increased OS in the testis, and lesions in testicular histology, as well as a reduction in testicular size and sperm quality parameters (motility, viability, and concentration).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with whole tomato lipid extract significantly decreased the weight of gonadal adipose tissue and OS, maintained testicular size, showed a significant increase in sperm quality parameters and improved histology of seminiferous tubules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results demonstrate a greater therapeutic and beneficial effect of the tomato lipid extract on sperm quality parameters in obese rats and therefore on fertility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13736","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T13:38:56Z","timestamp":1724765936000},"page":"955-967","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Whole tomato lipidic extract improved sperm quality in obese rats induced by a high\u2010carbohydrate diet"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0219-3139","authenticated-orcid":false,"given":"V\u00e1zquez Mendoza","family":"Luis Heriberto","sequence":"first","affiliation":[{"name":"Departamento de Farmacobiolog\u00eda Centro de Investigaci\u00f3n y de Estudios Avanzados del IPN  Sede Sur M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mailloux Salinas","family":"Patrick","sequence":"additional","affiliation":[{"name":"Departamento de Farmacobiolog\u00eda Centro de Investigaci\u00f3n y de Estudios Avanzados del IPN  Sede Sur M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Campos P\u00e9rez","family":"Elihu","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda Hospital General Dra. 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