{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:09:24Z","timestamp":1783631364130,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301800"],"award-info":[{"award-number":["82301800"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101685"],"award-info":[{"award-number":["82101685"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2702600"],"award-info":[{"award-number":["2022YFC2702600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>With the development of socio\u2010economic conditions and a shift in attitudes towards fertility, there has been a gradual increase in delayed childbearing since the 2000s. Age\u00a0plays a significant role in the decline of fertility. However, we know very little about the association of paternal age with reproductive outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the correlation between advanced paternal age and semen quality, embryo quality, pregnancy, and neonatal outcomes in IVF cycles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In this study, after excluding female partners aged \u226535 years, we analyzed data from 761 infertile couples who underwent in vitro fertilization cycles at the First Affiliated Hospital of USTC between June 2020 and March 2023. Cases were classified into three groups according to the age of the male: &lt;35 years (530 infertile couples), 35 years \u2264 paternal age &lt;40 years (125 infertile couples), and \u226540 years (106 infertile couples). Then, we compared the general clinical data arising from in vitro fertilization cycles between the three groups, including semen parameters, embryonic parameters, and pregnancy and neonatal birth outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data analysis showed that the duration of infertility and the incidence of secondary infertility were significantly higher in paternal age \u226535 years groups than those aged &lt;35 years (all <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>0.05). We also observed a significant difference between \u226540 years and &lt;35 years groups in terms of the normal fertilization rate, high\u2010quality embryo rate, clinical pregnancy rate, miscarriage rate, live birth rate, Apgar scores, and the low birth weight neonatal rate (all <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>0.05). The group with paternal age \u226540 years showed statistically significant differences in terms of clinical pregnancy rate, miscarriage rate, live birth rate, and low birth weight on multivariable logistic regression (all <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of our study indicate that advanced paternal age (\u226540 years) has a significant impact on the embryo quality, pregnancy outcome, and neonatal outcome. Paternal age over 40 years is a risk for in vitro fertilization success rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13745","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T14:09:58Z","timestamp":1724854198000},"page":"830-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High risk of low birth weight in couples with advanced paternal age in in vitro fertilization treatment"],"prefix":"10.1111","volume":"13","author":[{"given":"Yangyang","family":"Wan","sequence":"first","affiliation":[{"name":"Division of Life Sciences and Medicine Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Urology The Third Affiliated Hospital of Anhui Medical 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