{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T20:23:31Z","timestamp":1774556611498,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,12,8]],"date-time":"2024-12-08T00:00:00Z","timestamp":1733616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Congenital absence of the vas deferens (CAVD) is a syndrome with a heterogeneous presentation: bilateral (CBAVD) or unilateral (CUAVD), complete or partial and associated or not with other anomalies of the male urogenital system. A turning point came in 1968 when CBAVD was associated with cystic fibrosis and its <jats:italic>CFTR<\/jats:italic> gene mutations. Genetic studies then revealed that a minority of CBAVD but a majority of CUAVD are <jats:italic>CFTR<\/jats:italic>\u2010independent. In the literature, reference is classically made to two sources from the 18th and 19th century: Hunter and Reverdin. This scarcity prompted us to look for additional observations of CAVD. By a meticulous bibliographical search, we identified a corpus of 10 European observations (8 CUAVD and 2 CBAVD) some of them richly illustrated. They were collected between 1755 and 1876 throughout adult men autopsies. We also provided their primary and unambiguous sources. Analysis of the reported data revealed some interesting facts: both CBAVD cases were unlikely linked to cystic fibrosis and half of CUAVD cases were associated with an ipsilateral kidney absence, suggesting a <jats:italic>CFTR<\/jats:italic>\u2010independent pathophysiology. Moreover, the anatomical details of the anomalies raise interesting embryological questions we have tried to address in the light of current data. This work made it possible to identify new historical sources dealing with male genital tract pathologies. It sheds light on the origins of andrology and opens up interesting prospects for research and education in the field.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.13815","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T07:21:10Z","timestamp":1733728870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Congenital absence of vas deferens: Anatomical and embryological inputs from a series of autopsies reported in Europe throughout the 18th and 19th century"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1633-7735","authenticated-orcid":false,"given":"Marion","family":"Bendayan","sequence":"first","affiliation":[{"name":"Service de Biologie de la Reproduction\u2010Andrologie\u2010CECOS H\u00f4pital de Poissy Saint Germain en Laye  Poissy France"},{"name":"\u00c9cole Nationale V\u00e9t\u00e9rinaire d'Alfort, Universit\u00e9 Paris\u2010Saclay, BREED  Maisons\u2010Alfort France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5322-0141","authenticated-orcid":false,"given":"Florence","family":"Boitrelle","sequence":"additional","affiliation":[{"name":"Service de Biologie de la Reproduction\u2010Andrologie\u2010CECOS H\u00f4pital de Poissy Saint Germain en Laye  Poissy France"},{"name":"\u00c9cole Nationale V\u00e9t\u00e9rinaire d'Alfort, Universit\u00e9 Paris\u2010Saclay, BREED  Maisons\u2010Alfort France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2434-3441","authenticated-orcid":false,"given":"Safouane","family":"Maurens\u2010Hamdi","sequence":"additional","affiliation":[{"name":"Centre d\u2019\u00e9pid\u00e9miologie et de recherche en sant\u00e9 des populations (CERPOP), Universit\u00e9 Toulouse III Paul\u2010Sabatier  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-020-02122-w"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu042"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66152-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13062"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.06.012"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1982.tb00692.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7408412"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0377-1237(17)30530-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2022.151922"},{"key":"e_1_2_8_11_1","first-page":"225","volume-title":"Observations on Certain Parts of the Animal Economy","author":"Hunter J","year":"1786"},{"key":"e_1_2_8_12_1","unstructured":"BrugnoneG.Observations sur les v\u00e9sicules s\u00e9minales.M\u00e9moires de l'Acad\u00e9mie royale des sciences de Turin. 1787\u20101786:625."},{"key":"e_1_2_8_13_1","first-page":"26","volume-title":"Dissertatio sistens observationem de vesiculae seminalis sinistrae defectu, integris testibus, vase vero deferente sinistro clauso","author":"Bosscha H","year":"1813"},{"key":"e_1_2_8_14_1","unstructured":"PagetJ.Case of congenital imperfection of the vas deferens and testicle.London Medical Gazette. 1840\u20131841; 2(new series):817\u2010822."},{"key":"e_1_2_8_15_1","first-page":"148","volume-title":"Recherches t\u00e9ratologiques sur l'appareil s\u00e9minal de l'homme","author":"Godard E","year":"1860"},{"key":"e_1_2_8_16_1","unstructured":"GosselinL.M\u00e9moire sur les oblit\u00e9rations des voies spermatiques.Archives g\u00e9n\u00e9rales de M\u00e9decine. 1847; 4\u00e8mes\u00e9rie tome XIV:408."},{"key":"e_1_2_8_17_1","unstructured":"ReverdinJL.Absence du rein de l'uret\u00e8re du canal d\u00e9f\u00e9rent et de la v\u00e9sicule s\u00e9minale du c\u00f4t\u00e9 gauche; existence des deux testicules dans les bourses.Bulletins de la Soci\u00e9t\u00e9 Anatomique de Paris. 1870; 5\u00e8mes\u00e9rie 15:325\u2010326."},{"issue":"2","key":"e_1_2_8_18_1","first-page":"187","article-title":"Congenital absence of both Vasa Deferentia","volume":"58","author":"Little TE","year":"1874","journal-title":"Dublin J Med Sci"},{"key":"e_1_2_8_19_1","unstructured":"MayorA.Absence du rein de l'uret\u00e8re du canal d\u00e9f\u00e9rent et de la v\u00e9sicule s\u00e9minale du c\u00f4t\u00e9 gauche.Bulletins de la Soci\u00e9t\u00e9 Anatomique de Paris. 1876; 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