{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:11Z","timestamp":1787013851298,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371635"],"award-info":[{"award-number":["82371635"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although some studies suggest that sleep deprivation may affect ejaculation regulation, related research is limited, and the mechanisms remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to explore whether sleep deprivation influences ejaculation regulation through amyloid\u2010beta and to investigate its potential mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Normal ejaculating rats were randomly distributed into three separate groups for the study, and treated with sleep deprivation combined with saline gavage, sleep deprivation combined with sodium butyrate gavage, and control with saline gavage. The levels of amyloid\u2010beta and 5\u2010HT\n                      <jats:sub>1A<\/jats:sub>\n                      receptors were assessed through Western blotting, PCR, and immunohistochemical techniques. The levels of interleukin\u20104 and serotonin (5\u2010hydroxytryptamine) in the brain were determined by enzyme\u2010linked immunosorbent assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The experiment showed that the rats in the sleep deprivation combined with saline gavage group rats had a significantly faster ejaculation compared to the control combined with saline gavage group rats. Meanwhile, sleep deprivation combined with saline gavage group had the highest levels of amyloid\u2010beta oligomers in the brain tissue. Correlation results revealed that the levels of amyloid\u2010beta oligomers in brain tissue were inversely related to ejaculation latency and positively associated with ejaculation frequency. Furthermore, we found that elevated levels of amyloid\u2010beta oligomers in brain tissue led to upregulation of 5\u2010HT\n                      <jats:sub>1A<\/jats:sub>\n                      receptor expression. Additionally, elevated levels of amyloid\u2010beta oligomers in brain tissue were found to increase interleukin\u20104 levels, thereby reducing 5\u2010hydroxytryptamine levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      Sleep deprivation indeed accelerates ejaculation, and this acceleration is closely related to amyloid\u2010beta. Sleep deprivation can increase amyloid\u2010beta levels in brain tissue, mediating a decrease in 5\u2010hydroxytryptamine levels and overexpression of 5\u2010HT\n                      <jats:sub>1A<\/jats:sub>\n                      receptors, thereby accelerating ejaculation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is a significant correlation between elevated amyloid\u2010beta levels in brain tissue because of sleep deprivation and accelerated ejaculation. This study's main findings offer insights into the development of acquired premature ejaculation linked to poor sleep and establish a theoretical framework for investigating potential treatments for this condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.13826","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T04:59:27Z","timestamp":1734670767000},"page":"1958-1969","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The involvement of amyloid\u2010\u03b2 in the central nervous system regulation underlying sleep deprivation\u2010induced rapid ejaculation in rats"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3739-5047","authenticated-orcid":false,"given":"Peng","family":"Yang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Anhui Medical University  Hefei 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