{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:29:44Z","timestamp":1761863384962},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Phosphodiestrase\u20105 inhibitors are an important line of treatment for erectile dysfunction (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>). To detect the clinical and hemodynamic predictors of sildenafil response, we conducted this study on 124 Egyptian men with <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>. All patients were evaluated by thorough history and clinical assessment with measurement of the abridged international index of erectile function\u20105 (<jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\u20105) score. All patients were then subjected to intracavernosal injection (<jats:styled-content style=\"fixed-case\">ICI<\/jats:styled-content>) of trimix and pharmaco\u2010penile duplex ultrasonography (<jats:styled-content style=\"fixed-case\">PPDU<\/jats:styled-content>). Patients were then classified into sildenafil responders and non\u2010responders after six consecutive doses of 100\u00a0mg sildenafil. On doing the binary logistic stepwise regression analysis, only <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> duration, <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\u20105 score, and response to <jats:styled-content style=\"fixed-case\">ICI<\/jats:styled-content> were the significant independent predictors of sildenafil response. These three parameters together correctly predicted the sildenafil response by 81.5% (<jats:italic>p<\/jats:italic> value &lt;0.001). With the receiver operator characteristic curve analysis, the cut\u2010off value of <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> duration was 2.5\u00a0years and it was 14 for the <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\u20105 score. These findings indicate that <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> duration, the <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\u20105 score and response to <jats:styled-content style=\"fixed-case\">ICI<\/jats:styled-content> are more significant predictors of sildenafil response than the more expensive and time\u2010consuming <jats:styled-content style=\"fixed-case\">PPDU<\/jats:styled-content> testing.<\/jats:p>","DOI":"10.1111\/andr.271","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T03:55:13Z","timestamp":1422849313000},"page":"241-246","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical predictive factors of sildenafil response: a penile hemodynamic study"],"prefix":"10.1111","volume":"3","author":[{"given":"S. M.","family":"Elhanbly","sequence":"first","affiliation":[{"name":"Andrology Unit Mansoura University Hospital Mansoura Faculty of Medicine Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.\u2010M.","family":"Elkholy","sequence":"additional","affiliation":[{"name":"Andrology Unit Mansoura University Hospital Mansoura Faculty of Medicine Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Alghobary","sequence":"additional","affiliation":[{"name":"Andrology Unit Mansoura University Hospital Mansoura Faculty of Medicine Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Abou Al\u2010Ghar","sequence":"additional","affiliation":[{"name":"Radiology Department Urology Center Mansoura Faculty of Medicine Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-004-0423-y"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01764.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2004.00947.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64028-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2001.tb02582.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900805"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmhg.2006.08.007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200868020-00006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.02.020"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7262.2007.00227.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-00986-4_9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/tam.6.2.94.99"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31819c76e9"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.00988.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006153422407"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01688-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2000.tb139304.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.03.093"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.07.006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901492"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05301.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1615\/JLongTermEffMedImplants.v13.i6.80"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900472"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02869.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02953.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)42059-3"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900351"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.03.030"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.271","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T17:19:35Z","timestamp":1696526375000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/andr.271"],"URL":"https:\/\/doi.org\/10.1111\/andr.271","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"2013-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}