{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:28:42Z","timestamp":1790116122142,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypogonadism and infertility are two conditions that are heavily affected by overweight and obesity in the male patient. Glucagon\u2010like peptide 1 agonists (GLP\u20101RAs) are a recently introduced class of antidiabetic drugs with powerful weight\u2010loss effect; this may induce an indirect positive effect on the testicular function. Nevertheless, recent evidence also suggests a potential direct influence of these molecules on the gonadal function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Our study aims at evaluating the effects of GLP\u20101RAs on hormone secretion in male patients and comparing their impact on the testicular function with other antidiabetic agents or weight\u2010lowering drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A literature search was conducted using PubMed, EMBASE, and Scopus database to assess the effects of GLP\u20101RAs on hormone levels, sperm parameters, and erectile function in overweight and obese men. Before\u2013after analysis and comparison between therapy with GLP\u20101RAs and other treatment regimens were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0680) were included in the quantitative analysis. Treatment with GLP\u20101RAs produced a significant increase in total serum testosterone (TT), with a standardized mean difference of 1.39\u00a0ng\/mL (95% confidence interval: 0.70, 2.09;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). Free serum testosterone (FT), sex hormone\u2010binding globulin (SHBG), luteinizing hormone (LH), and follicle\u2010stimulating hormone (FSH) showed similar increase, while weight, body mass index (BMI), waist circumference (WC), and glycated hemoglobin (HbA1c) decreased. Meta\u2010regression showed a significant negative correlation between standardized mean difference in TT levels before\u2013after treatment and percentage change in weight and BMI. When compared with other treatment options, GLP\u20101RAs showed a comparable effect on serum androgens, but greater BMI reduction and increase in serum gonadotropins and indexes of the erectile function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our systematic review and meta\u2010analysis suggest a possible role for GLP\u20101RAs in the therapy of functional hypogonadism related to overweight and obesity, while also promoting weight loss. The limitations of the current literature do not allow to demonstrate a direct action of GLP\u20101RAs on the testicular function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70022","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T07:01:58Z","timestamp":1742367718000},"page":"2022-2034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Effects of glucagon\u2010like peptide 1 receptor agonists on testicular dysfunction: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9290-5699","authenticated-orcid":false,"given":"Gianmaria","family":"Salvio","sequence":"first","affiliation":[{"name":"Endocrinology Clinic, Department of Clinical and Molecular Sciences Polytechnic University of Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Ciarloni","sequence":"additional","affiliation":[{"name":"Endocrinology Clinic, Department of Clinical and Molecular Sciences Polytechnic University of Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Ambo","sequence":"additional","affiliation":[{"name":"Endocrinology Clinic, Department of Clinical and Molecular Sciences Polytechnic University of Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Bordoni","sequence":"additional","affiliation":[{"name":"Endocrinology Clinic, Department of Clinical and Molecular Sciences Polytechnic University of Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Perrone","sequence":"additional","affiliation":[{"name":"Endocrinology Clinic, Department of Clinical and Molecular Sciences Polytechnic University of Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Rossi","sequence":"additional","affiliation":[{"name":"Endocrinology Clinic, Department of Clinical and Molecular Sciences Polytechnic University of Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Balercia","sequence":"additional","affiliation":[{"name":"Endocrinology Clinic, Department of Clinical and Molecular Sciences Polytechnic University of Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.180055"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105497"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007\u20101972"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018\u201000229"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13617"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101018\u20109106"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607141"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603827"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d7771"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15535"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S387116"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75276"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098\u2010023\u201001233\u20104"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.2.7326"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12871"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa031"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13015"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa164"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_21_1","unstructured":"WellsG SheaB O'ConnelD et\u00a0al.The Newcastle\u2013Ottawa scale (NOS) for assessing the quality of non\u2010randomized studies in meta\u2010analysis.2000. Accessed August 14 2024.http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13039"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12099"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13519"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12966"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12754"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC\u201018\u20100514"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12020672"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac096"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000526808"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15127"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010022\u201004562\u20101"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glq002"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201009\u20100943"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1238090"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23\u20101630"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010022\u201002153\u2010x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2023.11.007"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102023\u2010076410"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad192"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc24\u2010S009"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/boiler\/iox087"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE\u201023\u20100105"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010012\u20109780\u20102"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2013.10.013"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.70022","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:08:48Z","timestamp":1772986128000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.70022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,19]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/andr.70022"],"URL":"https:\/\/doi.org\/10.1111\/andr.70022","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,19]]},"assertion":[{"value":"2024-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}