{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:50:33Z","timestamp":1788846633859,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Real\u2010world data on Peyronie's disease remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Describe the demographics, clinical characteristics, and therapeutic management of Peyronie's disease patients in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted using the PearlDiver Mariner database (2010\u20132022). Male adults with Peyronie's disease were identified using the International Classification of Diseases codes. Data included demographics, clinical conditions, and treatments. Analysis was performed using R\u2010based software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 176,969 patients (mean age 58.9 years), hypertension (72.9%), diabetes (40.4%), and obesity (31.1%) were the most common comorbidities. Smoking was prevalent in 41.5%. Dupuytren's contracture affected 3.1%, penile trauma 0.2%, erectile dysfunction 28.2%, and depression 19%. Most patients were from the southern US (42.9%). Social determinants of health were noted in 30.9%.<\/jats:p>\n                    <jats:p>\n                      Treatment was received by only 13.2%. Intraplaque injections were the most frequent therapy (7.2%) and showed an increasing trend (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.014). Surgical interventions (8.1%) included plication (35.1%), grafting (13%), prosthesis implantation (36.2%), and multiple techniques (15.7%). Grafting was linked to higher de novo erectile dysfunction risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Hypertension, diabetes, and smoking are frequent among Peyronie's disease patients. Erectile dysfunction and depression are common within a year of diagnosis. Despite multiple treatment options, only 15% of patients receive therapy. Injections are increasingly preferred, while surgery remains underutilized. Inflatable prostheses are the favored option for prosthetic management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Peyronie's disease patients often have significant comorbidities. Treatment rates are low, with injections as the most used therapy. Surgical interventions are less common, with stable trends over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70029","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T05:03:42Z","timestamp":1744088622000},"page":"2265-2272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Peyronie's disease in the United States: A real\u2010world, 13\u2010year nationwide analysis of demographics, clinical characteristics, and treatment trends"],"prefix":"10.1111","volume":"13","author":[{"given":"Angelo","family":"Orsini","sequence":"first","affiliation":[{"name":"Department of Urology Rush University  Chicago Illinois USA"},{"name":"Department of Urology D'Annunzio University of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1140-0590","authenticated-orcid":false,"given":"Eugenio","family":"Bologna","sequence":"additional","affiliation":[{"name":"Department of Maternal\u2010Child and Urological Sciences Sapienza University Rome, Policlinico Umberto I Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4269-6663","authenticated-orcid":false,"given":"Gabriele","family":"Bignante","sequence":"additional","affiliation":[{"name":"Department of Urology Rush University  Chicago Illinois USA"},{"name":"Department of Oncology Division of Urology University of Turin, San Luigi Gonzaga Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Lasorsa","sequence":"additional","affiliation":[{"name":"Department of Urology Rush University  Chicago Illinois USA"},{"name":"Department of Precision and Regenerative Medicine and Ionian Area\u2010Urology Division of Urology Andrology and Kidney Transplantation Unit University of Bari \u201cAldo Moro\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Lambertini","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence, Unit of Oncologic Minimally\u2010Invasive Urology and Andrology, Careggi Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Biasatti","sequence":"additional","affiliation":[{"name":"Department of Urology Rush University  Chicago Illinois USA"},{"name":"Urological Clinic Department of Medicine Surgery and Health Sciences University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Liguori","sequence":"additional","affiliation":[{"name":"Urological Clinic Department of Medicine Surgery and Health Sciences University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Marchioni","sequence":"additional","affiliation":[{"name":"Department of Urology D'Annunzio University of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Porpiglia","sequence":"additional","affiliation":[{"name":"Department of Oncology Division of Urology University of Turin, San Luigi Gonzaga Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lucarelli","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area\u2010Urology Division of Urology Andrology and Kidney Transplantation Unit University of Bari \u201cAldo Moro\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Schips","sequence":"additional","affiliation":[{"name":"Department of Urology D'Annunzio University of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5282-2335","authenticated-orcid":false,"given":"Davide","family":"Arcaniolo","sequence":"additional","affiliation":[{"name":"Department of Woman Child and General and Specialized Surgery Urology Unit University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"De Sio","sequence":"additional","affiliation":[{"name":"Department of Woman Child and General and Specialized Surgery Urology Unit University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward E.","family":"Cherullo","sequence":"additional","affiliation":[{"name":"Department of Urology Rush University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7045-7725","authenticated-orcid":false,"given":"Riccardo","family":"Autorino","sequence":"additional","affiliation":[{"name":"Department of Urology Rush University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9706-8516","authenticated-orcid":false,"given":"Celeste","family":"Manfredi","sequence":"additional","affiliation":[{"name":"Department of Woman Child and General and Specialized Surgery Urology Unit University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.05.098"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2007.00614.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01785.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2011.36"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152812798889321"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01850.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900877"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/sm2.45"},{"key":"e_1_2_10_10_1","unstructured":"European Association of Urology.Sexual and Reproductive Health.2024. Available from:https:\/\/uroweb.org\/guidelines\/sexual\u2010and\u2010reproductive\u2010health\/chapter\/penile\u2010curvature"},{"key":"e_1_2_10_11_1","volume-title":"Peyronie's Disease Guideline","author":"American Urological Association","year":"2015"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esxm.2016.01.002"},{"key":"e_1_2_10_13_1","first-page":"291","article-title":"Evaluation of intralesional injection of verapamil in treatment of Peyronie's disease","volume":"60","author":"Heidari M","year":"2010","journal-title":"J Pak Med Assoc"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2012.92"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sxmr.2020.07.008"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900515"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-4096.2001.02436.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37988-0"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/282503"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41443-020-00363-x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02868.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000049830"},{"key":"e_1_2_10_23_1","article-title":"Cost of intralesional collagenase Clostridium histolyticum therapy versus surgery for the management of Peyronie's disease: a claims\u2010based analysis (2009\u20102019)","volume":"10","author":"Walton EL","year":"2022","journal-title":"Sex Med"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41443-022-00658-1"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000053800.62741.fe"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.05969.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.06611.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2011.18"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65361-8"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.00895.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12838"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.00949.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.200065"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(06)00270-9"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241210133"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2003.12.002"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.01.087"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13096"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.07.005"},{"key":"e_1_2_10_40_1","unstructured":"Endo Inc.Learn about Peyronie's Disease Treatment | XIAFLEX\u00ae.2025. Available from:https:\/\/peyronies\u2010disease.xiaflex.com\/patient\/about\u2010xiaflex\/"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2010.233"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2006.00404.x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01971.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.10023.x"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70029","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.70029","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:09:20Z","timestamp":1772986160000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.70029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,7]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/andr.70029"],"URL":"https:\/\/doi.org\/10.1111\/andr.70029","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,7]]},"assertion":[{"value":"2024-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}