{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T11:43:57Z","timestamp":1764675837106,"version":"3.46.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Only approximately 30% of conceptions result in live births. Historically, research has predominantly focused on maternal factors impacting pregnancy success, despite the cause remaining unidentified in most cases. The influence of paternal factors on a couple's likelihood of achieving a successful pregnancy is still not well understood and warrants further investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to examine the chance of biochemical pregnancy, clinical pregnancy, and a live\u2010born child in couples where the male partner has ischemic heart disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>This nationwide cohort study based on Danish health registries included couples undergoing in vitro fertilization with or without intracytoplasmic sperm injection from 2006 to 2019. The cohort was divided into two groups: exposed and unexposed. The exposed cohort included embryo transfers in couples where the male partner had ischemic heart disease, while the unexposed group included those where the male partner did not have this condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 101,875 couples with a known male partner were included. Among these, 653 couples were included in the exposed cohort and 101,222 were included in the unexposed cohort. The adjusted odd ratios (ORs) for a biochemical pregnancy, clinical pregnancy, and live\u2010born child were 0.99 (95% confidence interval [CI]: 0.79; 1.23), 0.79 (95% CI: 0.51, 1.23), and 0.94 (95% CI: 0.62, 1.44), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate that paternal ischemic heart disease prior to oocyte retrieval is not associated with a statistically significant decrease in the chances of biochemical pregnancy, clinical pregnancy, or live birth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70065","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T04:23:49Z","timestamp":1747887829000},"page":"132-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paternal ischemic heart disease and chance of successful pregnancy outcomes"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0436-0294","authenticated-orcid":false,"given":"Anne\u2010Sofie","family":"S\u00f8nnichsen\u2010Dreehsen","sequence":"first","affiliation":[{"name":"Centre of Andrology &amp; Fertility Clinic Odense University Hospital &amp; University of Southern Denmark  Odense Denmark"},{"name":"Center for Clinical Epidemiology Odense University Hospital  Odense Denmark"},{"name":"Research Unit of Clinical Epidemiology Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4236-5647","authenticated-orcid":false,"given":"Caroline Theilgaard","family":"Thorarinsson","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology Odense University Hospital  Odense Denmark"},{"name":"Research Unit of Clinical Epidemiology Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9514-3033","authenticated-orcid":false,"given":"Bente Mertz","family":"N\u00f8rg\u00e5rd","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology Odense University Hospital  Odense Denmark"},{"name":"Research Unit of Clinical Epidemiology Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5383-5501","authenticated-orcid":false,"given":"Jens","family":"Fedder","sequence":"additional","affiliation":[{"name":"Centre of Andrology &amp; Fertility Clinic Odense University Hospital &amp; University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9765-7321","authenticated-orcid":false,"given":"Mette","family":"Wod","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology Odense University Hospital  Odense Denmark"},{"name":"Research Unit of Clinical Epidemiology Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00459-w"},{"key":"e_1_2_9_3_1","unstructured":"The Danish Health Data Authority.Assisted Reproduction Denmark 2019 [Internet]. Tilg\u00e6ngelig hos:https:\/\/sundhedsdatastyrelsen.dk\/\u2010\/media\/sds\/filer\/find\u2010tal\u2010og\u2010analyser\/sygdomme\u2010og\u2010behandlinger\/assisteret\u2010reproduktion\/assisteret\u2010reproduktion\u20102019.pdf"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5603\/GP.2016.0038"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311246"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2017.03.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-13733"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.31128\/AJGP-01-18-4459"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S146496"},{"key":"e_1_2_9_10_1","unstructured":"https:\/\/fertilitetsselskab.dk\/wp\u2010content\/uploads\/2024\/04\/BMI_Guideline\u201011032022.pdf"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000214"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513815.2018.1455775"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izae132"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13702"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.14259"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy005"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-017-2407-8"},{"issue":"2","key":"e_1_2_9_18_1","first-page":"505","article-title":"Effects of varicocele repair on spontaneous first trimester miscarriage: a randomized clinical trial","volume":"9","author":"Mansour Ghanaie M","year":"2012","journal-title":"Urol J"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa332"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.04.037"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2011.01213.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2022.01.007"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28350"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179875"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-021-00742-8"},{"issue":"4","key":"e_1_2_9_26_1","first-page":"357","article-title":"The Danish in vitro fertilisation (IVF) register","volume":"46","author":"Andersen AN","year":"1999","journal-title":"Dan Med Bull"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2000.079005384.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0356-1"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(96)00018-2"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"issue":"3","key":"e_1_2_9_32_1","first-page":"798","article-title":"Data resource profile: the Danish national prescription registry","volume":"46","author":"Potteg\u00e5rd A","year":"2017","journal-title":"Int J Epidemiol"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.028620"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der305"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.08.015"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13776"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13592"},{"issue":"42","key":"e_1_2_9_38_1","first-page":"716","article-title":"The treatment of coronary artery disease","volume":"119","author":"Doenst T","year":"2022","journal-title":"Dtsch Arzteblatt Int"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2023.2201437"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11216595"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-013-9873-0"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0320-7"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T11:40:15Z","timestamp":1764675615000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.70065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/andr.70065"],"URL":"https:\/\/doi.org\/10.1111\/andr.70065","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"type":"print","value":"2047-2919"},{"type":"electronic","value":"2047-2927"}],"subject":[],"published":{"date-parts":[[2025,5,22]]},"assertion":[{"value":"2024-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}