{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:56:58Z","timestamp":1772989018509,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Couple infertility is a very ancient medical condition. One of the first descriptions of familial infertility\/subfertility is contained in the first book of the Bible, Genesis, written in the 10th century BC and reporting tales from the oral tradition even occurred about 800 years earlier. Genesis reports the peculiar case of Abraham and his descendants, Isaac and Jacob, the three patriarchs of Israel. The (favorite) wife of the three of them suffered from primary infertility and, according to Genesis, could reach pregnancy only in late age and for divine intervention. In this paper, we reconstruct the pedigree of Abraham's family on the basis of the biblical narration, which is rich enough of medical details to allow to reconstruct a plausible medical\/genetic reason for the cases of infertility reported therein.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70103","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T02:33:28Z","timestamp":1754102008000},"page":"641-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetics of infertility and \u201cassisted fertilization\u201d in the Bible: The case of Abraham and his family"],"prefix":"10.1111","volume":"14","author":[{"given":"Manuela","family":"Simoni","sequence":"first","affiliation":[{"name":"Department of Biomedical Metabolic and Neural Sciences Baggiovara Hospital University of Modena and Reggio Emilia  Modena Italy"},{"name":"Unit of Endocrinology Department of Medical Specialties Azienda Ospedaliero\u2010Universitaria of Modena  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"T\u00fcttelmann","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Genetics Centre of Medical Genetics University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livio","family":"Casarini","sequence":"additional","affiliation":[{"name":"Department of Biomedical Metabolic and Neural Sciences Baggiovara Hospital University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.7759\/CUREUS.44792"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014469500003892"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115874"},{"issue":"2","key":"e_1_2_12_5_1","first-page":"95","article-title":"The devil's apples","volume":"3","author":"Cule J","year":"1997","journal-title":"Vesalius"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201031064\u20102"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109384(95)00029\u2010I"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PBB.2011.08.003"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091\u20103057(93)90024\u2010N"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109384(89)90301\u20106"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091\u20103057(99)00035\u20100"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0890\u20106238(02)00050\u20103"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.30.207"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15474"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo\u2010126\u20102\u20101256"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/01485019008987600"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FERTNSTERT.2011.11.019"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090\u20104295(75)90080\u20101"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/NCOMMS8502"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/NCOMMS9464"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/NG.732"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PGEN.1007813"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/NG.2384"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/ENDREV\/BNAE007"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/EN.2019\u201000013"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ANDR.13821"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11154\u2010011\u20109192\u20102"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BEEM.2021.101594"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/NG0297\u2010205"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.03.008"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FERTNSTERT.2010.09.032"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JUS.2007.09.006"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513599009030691"},{"key":"e_1_2_12_34_1","unstructured":"VallisneriA HertzGG GarelliNP KarlVI.Istoria Della GenerazioneDell'uomo e DegliAnimali Se Sia Da\u2019 Vermicelli Spermatici o Dalle Uova; 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