{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:40:14Z","timestamp":1791567614043,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Androgen receptors are highly expressed in upper body muscles, but changes in maximal muscle strength and power in major upper body muscles have not been investigated during gender\u2010affirming hormone therapy (GAHT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess prospective changes in maximal muscle strength and muscle power from before and after 1 year of GAHT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and Methods<\/jats:title>\n                    <jats:p>Clinical prospective study in 92 transgender persons: 26 transmasculine treatment\u2010na\u00efve (TransM_na\u00efve), 27 transmasculine treatment\u2010ongoing (TransM_ongoing), 29 transfeminine treatment\u2010na\u00efve (TransF_na\u00efve), and 10 transfeminine treatment\u2010ongoing (TransF_ongoing) were examined at baseline and after 1 year of GAHT. Primary outcomes were unilateral upper body maximal muscle strength (kg) and mean and maximal power (watt) measured by low\u2010row dynamic testing. Dual\u2010energy X\u2010ray absorptiometry was conducted in all participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In transmasculine persons, the median (quartiles) age was 22 (20; 30) years in TransM_na\u00efve and 26 (22\u201329) years in TransM_ongoing (median GAHT duration 3 (2; 5) years) at study inclusion. Maximal muscle strength increased 6.3\u00a0kg (12%) in TransM_na\u00efve (\n                      <jats:italic>p<\/jats:italic>\n                      \u2264 0.001) and 5.0\u00a0kg (7%) in TransM_ongoing (\n                      <jats:italic>p<\/jats:italic>\n                      \u2264 0.001), while maximal muscle power remained unchanged. \u2206\u2010muscle strength was positively associated with \u2206\u2010lean mass in arms and negatively associated with age at GAHT initiation.\n                    <\/jats:p>\n                    <jats:p>In transfeminine persons, the median age was 24 (22; 30) years in TransF_na\u00efve and 40 (31\u201364) years in TransF_ongoing (median GAHT duration 4 (2; 6) years) at study inclusion. Maximal muscle strength decreased 17.5\u00a0kg (23%) in TransF_na\u00efve and \u20105.0\u00a0kg (8%) in TransF_ongoing, which was accompanied by a decrease (23%) in maximal muscle power in TransF_na\u00efve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Upper body muscle strength but not power increased during masculinizing GAHT, whereas muscle strength and power decreased within the first year of feminizing GAHT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70132","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:03:43Z","timestamp":1760159023000},"page":"2138-2149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Muscle Strength and Power Changes With Gender\u2010Affirming Hormone Therapy"],"prefix":"10.1111","volume":"14","author":[{"given":"Mathilde Kamp","family":"N\u00f8rlund","sequence":"first","affiliation":[{"name":"Department of Endocrinology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob Lindberg","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Sports Science and Clinical Biomechanics, Muscle Physiology and Biomechanics Research Unit University of Southern Denmark  Odense Denmark"},{"name":"Department of Clinical Research, Geriatric Research Unit University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne Skovsager","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke","family":"Hjortebjerg","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Odense Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laust Frisenberg","family":"Buhl","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Pernille","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla Viola Buskbjerg","family":"Palm","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine Taulbjerg","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Frystyk","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Aagaard","sequence":"additional","affiliation":[{"name":"Department of Sports Science and Clinical Biomechanics, Muscle Physiology and Biomechanics Research Unit University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Mathiesen","sequence":"additional","affiliation":[{"name":"Department of Sports Science and Clinical Biomechanics, Muscle Physiology and Biomechanics Research Unit University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte","family":"Glintborg","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6489-7054","authenticated-orcid":false,"given":"Louise Lehmann","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Odense University Hospital  Odense 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