{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:49:13Z","timestamp":1791438553036,"version":"4.3.3"},"reference-count":125,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Oxidative stress (OS) significantly contributes to male reproductive dysfunction, a factor implicated in a substantial fraction of infertility cases. This comprehensive review elucidates the intricate interplay between oxidative stress and male reproductive health, emphasizing the molecular and cellular mechanisms through which reactive oxygen species (ROS) impair sperm function. Key areas of focus include lipid peroxidation of sperm membranes, DNA damage, and apoptotic cell death, which collectively undermine sperm viability and fertility potential.<\/jats:p>\n                    <jats:p>The discussion extends to the impact of lifestyle and environmental factors on oxidative balance, highlighting how these elements intensify oxidative stress and subsequently exacerbate reproductive outcomes. Advances in therapeutic approaches are critically assessed, particularly the development and application of antioxidants in ameliorating oxidative damage and restoring reproductive functions. This review also explores innovative diagnostic techniques for detecting ROS and assessing oxidative damage within clinical settings, offering insights into future directions for research and clinical practice in managing male infertility related to oxidative stress.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70143","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T07:01:29Z","timestamp":1762758089000},"page":"1447-1460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Oxidative Stress and its Implications for Male Reproductive Dysfunction: Mechanistic Insights, Clinical Impacts, and Advances in Therapeutic Interventions"],"prefix":"10.1111","volume":"14","author":[{"given":"Xinru","family":"Yu","sequence":"first","affiliation":[{"name":"School of Pharmacy Shandong University of Traditional Chinese Medicine  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yike","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueran","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runhe","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Fan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medicine Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jie Ma","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Center of Integrative Medicine Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Song","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Center of Integrative Medicine Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Sun","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Center of Integrative Medicine Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102497"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-37972-8_9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008\u2010682X.122203"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008950.pub2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011010"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2105053118"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010022\u201001185\u20103"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004979\u20105"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010020\u201001208\u2010z"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010016\u20100418\u20108"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.05.004"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2012.717273"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12824"},{"key":"e_1_2_11_15_1","first-page":"115","article-title":"Okislenie vinnoi kisloty v vine v prisusstvii solei tiazhelykh metallov (aktivirovanie kisloroda zhelezom) [Oxidation of Tartaric Acid in Wine in the Presence of Heavy Metal Salts (Activation of Oxygen by Iron)]","volume":"3","author":"Rodopulo A. 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