{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T07:11:32Z","timestamp":1783926692162,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Platelet\u2010rich plasma (PRP) injection into penile plaques is an emerging, investigational approach for treating acquired penile curvature in men with stable\u2010phase Peyronie's Disease (PD). We report preliminary findings from a two\u2010center prospective pilot study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Thirty\u2010eight men with stable PD underwent two PRP injections (\u22488\u00a0mL each), 4\u00a0weeks apart. PRP was prepared using either double or single centrifugation (2\u2010cycle vs. 1\u2010cycle group). All patients initiated tadalafil 5\u00a0mg daily and penile stretching with a vacuum device (5\u201315\u00a0min\/day) 1\u00a0week after the first injection. Baseline and 3\u2010month follow\u2010up assessments included dynamic penile color doppler\u2010duplex ultrasound (CDDU), International Index of Erectile Function (IIEF), and Peyronie's disease questionnaire (PDQ).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010two patients (57.9%) received 2\u2010cycle PRP; 16 (42.1%) received 1\u2010cycle PRP. Baseline penile curvature was 45\u00b0 (37\u201370) in the 2\u2010cycle group and 60\u00b0 (50\u201366) in the 1\u2010cycle group, decreasing to 40\u00b0 (30\u201350) and 50\u00b0 (40\u201356), respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002 and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.008). Overall, median curvature decreased from 55\u00b0 (45\u201370) to 45\u00b0 (30\u201355), with a median reduction of 10\u00b0 (0\u201315) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). PDQ scores improved significantly in both groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2264\u00a00.006), while IIEF\u2010EF and CDDU parameters remained unchanged. Plaque diameter showed a non\u2010significant reduction. No treatment\u2010emergent adverse events occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PRP injections appear safe and may modestly improve penile curvature and PDQ scores in men with stable\u2010phase PD. However, the observed curvature reduction is insufficient to infer clinically meaningful long\u2010term outcomes. Larger controlled studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70176","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:18:11Z","timestamp":1768378691000},"page":"1300-1307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trimodal Mini\u2010Invasive Therapy for Stable\u2010Phase Peyronie's Disease: A Two\u2010Center Real\u2010Life Prospective Pilot Study"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3677-6412","authenticated-orcid":false,"given":"Fausto","family":"Negri","sequence":"first","affiliation":[{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"},{"name":"Division of Experimental Oncology\/Unit of Urology Urological Research Institute IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Department of Urology School of Medicine Stanford University  Stanford California 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