{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:20:16Z","timestamp":1790720416395,"version":"4.1.0"},"reference-count":122,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171264"],"award-info":[{"award-number":["32171264"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>This review summarizes the molecular and cellular mechanisms underlying busulfan\u2010induced male infertility and evaluates the translational potential of current and emerging therapeutic strategies. Evidence indicates that busulfan induces germ cell DNA alkylation damage, triggers sustained oxidative stress, and activates multiple cell death pathways. These events are accompanied by supporting cell dysfunction, disruption of the blood\u2013testis barrier (BTB), and endocrine imbalance, collectively driving progressive impairment of spermatogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>In response to these pathological processes, various interventions have been explored, including antioxidant molecules, natural extracts, epigenetic modulation, and stem cell\u2013related approaches, many of which show partial improvement of spermatogenic function in experimental models. In addition, clinical strategies used for other forms of male infertility, such as gonadotropin supplementation and antioxidant supportive therapy, provide relevant reference frameworks for chemotherapy\u2010associated fertility impairment. However, most studies on busulfan\u2010induced infertility remain preclinical, and their benefits largely reflect supportive modulation of the testicular microenvironment rather than definitive restoration of spermatogonial stem cells (SSCs) or repair of genotoxic damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Based on an integrated assessment of current evidence, this review highlights key unresolved challenges, including the lack of a defined therapeutic safety window, limitations in targeted delivery, and difficulties in achieving fundamental reconstruction of the spermatogenic system. Accordingly, future studies should place greater emphasis on more effective isolation and protection of testicular tissue, development of targeted drug delivery systems, and strategies aimed at spermatogenic system reconstruction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70189","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T08:51:02Z","timestamp":1770454262000},"page":"1929-1940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Busulfan\u2010Induced Male Infertility: Mechanisms, Therapeutic Interventions, and Future Directions"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1963-1361","authenticated-orcid":false,"given":"Tianyu","family":"Li","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Translational Medicine Center for Translational Medicine Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education West China Second University Hospital Sichuan University  Chengdu Sichuan P.R. China"},{"name":"West China School of Basic Medical Sciences and Forensic Medicine Sichuan University  Chengdu Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichen","family":"Tang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Translational Medicine Center for Translational Medicine Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education West China Second University Hospital Sichuan University  Chengdu Sichuan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8173-8581","authenticated-orcid":false,"given":"Yaping","family":"Song","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Translational Medicine Center for Translational Medicine Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education West China Second University Hospital Sichuan University  Chengdu Sichuan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Luo","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Translational Medicine Center for Translational Medicine Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education West China Second University Hospital Sichuan University  Chengdu Sichuan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Translational Medicine Center for Translational Medicine Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education West China Second University Hospital Sichuan University  Chengdu Sichuan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8718-206X","authenticated-orcid":false,"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Andrology Sichuan Human Sperm Bank West China Second University Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5183-4214","authenticated-orcid":false,"given":"Fuping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Andrology Sichuan Human Sperm Bank West China Second University Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8102-8851","authenticated-orcid":false,"given":"Yanyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Translational Medicine Center for Translational Medicine Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education West China Second University Hospital Sichuan University  Chengdu Sichuan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3294-7824","authenticated-orcid":false,"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Translational Medicine Center for Translational Medicine Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education West China Second University Hospital Sichuan University  Chengdu Sichuan P.R. China"},{"name":"West China School of Basic Medical Sciences and Forensic Medicine Sichuan University  Chengdu Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa781"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958\u2010015\u20100032\u20101"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.17076.1"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010023\u201000459\u2010w"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.08.015"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0890\u20106238(01)00182\u20104"},{"issue":"4","key":"e_1_2_12_8_1","first-page":"326","article-title":"Impact of Chemotherapy on Male Fertility","volume":"24","author":"Schrader M.","year":"2001","journal-title":"Onkologie"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2013.737319"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198312013092202"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165\u20101110(86)90020\u20105"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2017.01.002"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-022-01755-x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486165"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.08.010"},{"issue":"4","key":"e_1_2_12_16_1","first-page":"273","article-title":"Busulfan Induced Azoospermia: Stereological Evaluation of Testes in Rat","volume":"6","author":"Panahi M.","year":"2015","journal-title":"Veterinary Research Forum: An International Quarterly Journal"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703207"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2005.06.014"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349\u20107006.2004.tb03231.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1292683"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14010043"},{"issue":"4","key":"e_1_2_12_22_1","first-page":"2497","article-title":"PGAM1 Knockdown Is Associated With Busulfan\u2011Induced Hypospermatogenesis and Spermatogenic Cell Apoptosis","volume":"19","author":"Zhao Y.","year":"2019","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2018.08.002"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11863"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b00622"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3088"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2018.04.004"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.03.020"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1679330"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010014\u20100425\u20107"},{"issue":"2","key":"e_1_2_12_31_1","first-page":"73","article-title":"Therapeutic Effects of Edaravone on Azoospermia: Free Radical Scavenging and Autophagy Modulation in Testicular Tissue of Mice","volume":"23","author":"Ghaffari Novin M.","year":"2022","journal-title":"Journal of Reproduction & Infertility"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000028359"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.5935\/1518\u20100557.20200081"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2016.1243601"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9020134"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.220100"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192\u2010023\u201001379\u20100"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10050743"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1492256"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11122345"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010019\u201000107\u2010w"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2010.11.001"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.15"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8074"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1443"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401148"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201004\u20101367"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.104.030858"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.5.2926"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2019.0220"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.260091"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.157500"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00406"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1120034"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S403819"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2011.03.007"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015\u2010020\u201010027\u20104"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.010"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010023\u201001665\u2010x"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2020.152489"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-62026-4_4"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13148"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010020\u201000728\u20101"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(05)71008-5"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.04.020"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441\u2010024\u201003894\u20107"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.02.011"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20513"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2021.06.016"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1489"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925\u20104773(02)00004\u20107"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2016.0318"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2022.153193"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP\u201015\u20100463"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70263"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0322721"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06781"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13112"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2022.11.002"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.583135"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.125401"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12590"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2016.01.001"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioy059"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.03.007"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010012\u20101079\u20101"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176405"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107174"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1450561"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102796.1998.00390.x"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06\u2010070342"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.08.033"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.112.107052"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioac072"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2013.145"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9041014"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12198"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.129104"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081636"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.5653\/cerm.2013.40.2.60"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958\u2010019\u20100468\u20109"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13953"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12172"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917\u2010022\u201003186\u20108"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000004180"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.11.008"},{"issue":"1","key":"e_1_2_12_107_1","first-page":"57","article-title":"The Effects of Olive Leaf Extract on the Testis, Sperm Quality and Testicular Germ Cell Apoptosis in Male Rats Exposed to Busulfan","volume":"13","author":"Ganjalikhan Hakemi S.","year":"2019","journal-title":"International Journal of Fertility & Sterility"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2015.01.002"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.230254"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2019.03.001"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032\u2010024\u201001749\u20108"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000003126"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104\u2010025\u201001180\u20102"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201000932\u20100"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.15283\/ijsc.2015.8.2.134"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010018\u20100946\u20106"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116063"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978\u2010021\u201001242\u20104"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2024.02.003"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioae109"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010015\u20101833\u20105"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015\u2010020\u201010044\u20103"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010025\u201004729\u20100"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70189","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.70189","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:31:53Z","timestamp":1789993913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.70189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,7]]},"references-count":122,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/andr.70189"],"URL":"https:\/\/doi.org\/10.1111\/andr.70189","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,7]]},"assertion":[{"value":"2025-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}