{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:11:27Z","timestamp":1789996287940,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA226211"],"award-info":[{"award-number":["R01CA226211"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K24AG070078"],"award-info":[{"award-number":["K24AG070078"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Men undergoing androgen deprivation therapy (ADT) for prostate cancer experience various adverse effects. Those with higher pre\u2010treatment testosterone levels often express concerns about experiencing increased severity of these side effects, but this association has not been studied previously.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to assess the association of pre\u2010treatment testosterone levels with changes in body composition, physical function, sexual function, and energy in men undergoing 24 weeks of ADT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Thirty\u2010nine men were assessed at baseline and after 24 weeks of ADT. Body composition was assessed using dual\u2010energy x\u2010ray absorptiometry. Energy and vitality were evaluated using the Hypogonadism Energy Diary, and sexual function was assessed using the Sexual Arousal, Interest, and Drive scale. Physical function was assessed using the PF\u201010 subscale of the Short Form\u201036 Health Survey. Total and free testosterone levels were measured using liquid chromatography\u2010tandem mass spectrometry and equilibrium dialysis, respectively. The association between pre\u2010treatment testosterone levels and variables of interest was tested using linear regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Discussion<\/jats:title>\n                    <jats:p>\n                      At 24 weeks, the mean serum total testosterone level declined from 471\u00a0\u00b1\u00a0157 to 7.7\u00a0\u00b1\u00a04.5\u00a0ng\/dL, total fat mass increased by 3.7\u00a0kg (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.0001), and total lean mass decreased by 2.2\u00a0kg (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). Participants experienced a decline in physical function, overall energy, and sexual desire. Pre\u2010treatment testosterone levels were not associated with the magnitude of worsening in any of these outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Severity of adverse effects of ADT is not influenced by pre\u2010treatment testosterone levels. This finding allows clinicians and patients to make informed decisions regarding treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70194","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T14:35:29Z","timestamp":1771598129000},"page":"2244-2251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Pre\u2010treatment Testosterone Levels on Severity of Adverse Effects in Men on Androgen Deprivation Therapy for Prostate Cancer"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2996-1110","authenticated-orcid":false,"given":"Milena","family":"Braga","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Travison","sequence":"additional","affiliation":[{"name":"Hinda and Arthur Marcus Institute for Aging Research Hebrew SeniorLife Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Medicine Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary\u2010Ellen","family":"Taplin","sequence":"additional","affiliation":[{"name":"Lank Center for Genitourinary Oncology Dana\u2010Farber Cancer Institute Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Habtemariam","sequence":"additional","affiliation":[{"name":"Hinda and Arthur Marcus Institute for Aging Research Hebrew SeniorLife Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Medicine Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts 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