{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:07:51Z","timestamp":1789996071223,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Erectile dysfunction (ED) is a multidimensional condition commonly affecting men living with HIV. The structured interview of erectile dysfunction (SIEDY) is the only validated tool assessing organic, relational, and psychological factors contributing to ED, while dynamic penile color Doppler ultrasound (dPCDU) is a reliable method for evaluating vascular causes of ED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This monocentric cross\u2010sectional study aims to assess the reliability of the SIEDY questionnaire in determining the underlying causes of ED in young men living with HIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Young men (&lt;50 years) living with HIV, on antiretroviral therapy for at least the last 12 months, and reporting symptoms of ED were enrolled. The degree of sexual dysfunction was assessed with the International Index of Erectile Function\u20105 (IIEF\u20105), while SIEDY was used to explore the pathogenetic components of ED. dPCDU was performed to assess vascular damage in the penile district. Univariate binomial logistic regression models were used to evaluate the association between ultrasound parameters and SIEDY results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 50 young men living with HIV were enrolled, of whom 40 (80%) had at least one altered SIEDY scale, most frequently Scale 3 (70%). Forty\u2010five (90%) participants presented with at least one abnormal ultrasound parameter, with intima\u2010media thickness being the most common (76%). No correlation was found between ultrasound parameters and the SIEDY Scale 1, while logistic regression identified IMT as the only variable significantly associated with SIEDY Scales 2 (relational) and 3 (psychological).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusions<\/jats:title>\n                    <jats:p>SIEDY may have limited reliability in detecting vascular causes of ED in this population, particularly underestimating organic causes. The lack of correlation with objective vascular findings highlights the importance of including tools like dPCDU for vascular assessment in routine clinical evaluations of the ED.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70215","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T02:51:10Z","timestamp":1773111070000},"page":"2290-2296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["SIEDY Diagnostic Accuracy in Assessing Erectile Dysfunction in Young Men Living With HIV"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7366-871X","authenticated-orcid":false,"given":"Giorgio","family":"Tiecco","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Sciences Unit of Infectious and Tropical Diseases University of Brescia and ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4327-7305","authenticated-orcid":false,"given":"Federico","family":"Cesanelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences Unit of Infectious and Tropical Diseases University of Brescia and ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo","family":"Colangelo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences Unit of Infectious and Tropical Diseases University of Brescia and ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Di","family":"Gregorio","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences Unit of Infectious and Tropical Diseases University of Brescia and ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Delbarba","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences Unit of Endocrinology and Metabolism University of Brescia and ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9257-1043","authenticated-orcid":false,"given":"Paolo","family":"Facondo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences Unit of Endocrinology and Metabolism University of Brescia and ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Riva","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties Radiological Sciences and Public Health University of Brescia ASST Spedali Civili of Brescia Piazzale Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4317-1232","authenticated-orcid":false,"given":"Carlo","family":"Cappelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences Unit of Endocrinology and Metabolism University of Brescia and ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Foc\u00e0","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences Unit of Infectious and Tropical Diseases University of Brescia and ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Castelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences Unit of Infectious and Tropical Diseases University of Brescia and ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Quiros\u2010Roldan","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences Unit of Infectious and Tropical Diseases University of Brescia and ASST Spedali Civili di Brescia  Brescia Italy"},{"name":"Department of Global Public Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000003095"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.7954"},{"issue":"1","key":"e_1_2_11_4_1","first-page":"94","article-title":"Beyond Viral Suppression of HIV\u2014The New Quality of Life Frontier","volume":"14","author":"Lazarus J. 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