{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:49:39Z","timestamp":1791438579068,"version":"4.3.3"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJFR211F"],"award-info":[{"award-number":["JPMJFR211F"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJCR21N1"],"award-info":[{"award-number":["JPMJCR21N1"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23jf0126001"],"award-info":[{"award-number":["JP23jf0126001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD088412"],"award-info":[{"award-number":["R01HD088412"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The SCF (Skp\u2013Cullin\u2013F\u2010box) complex is a major class of E3 ubiquitin ligases. F\u2010box proteins constitute the SCF complex and play a critical role in recognizing substrates for ubiquitination. In mice, several F\u2010box proteins, including FBXO36 and FBXO39, are predominantly expressed in testes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the roles of FBXO36 and FBXO39 in mouse male reproduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We generated\n                      <jats:italic>Fbxo36<\/jats:italic>\n                      KO and\n                      <jats:italic>Fbxo39<\/jats:italic>\n                      KO mouse lines using the CRISPR\/Cas9 system. We evaluated male fertility, sections of reproductive organs, and sperm morphology and motility.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No overt abnormalities were found in male fertility or sperm morphology of\n                      <jats:italic>Fbxo36<\/jats:italic>\n                      KO mice. In contrast,\n                      <jats:italic>Fbxo39<\/jats:italic>\n                      KO males showed subfertility, abnormal sperm morphology, and reduced sperm motility. Histological analyses of testis sections revealed that FBXO39 is critical for the morphological transformation of round spermatids into spermatozoa.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings demonstrate that\n                      <jats:italic>Fbxo39<\/jats:italic>\n                      is important for spermiogenesis in mice, whereas\n                      <jats:italic>Fbxo36<\/jats:italic>\n                      is dispensable for male fertility. Further analyses of FBXO39 may contribute to understanding the etiology of male infertility.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70225","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T03:11:09Z","timestamp":1775013069000},"page":"1636-1646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Testis\u2010Enriched F\u2010Box Protein FBXO39 Is Important for Spermiogenesis and Male Fertility in Mice"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6300-4234","authenticated-orcid":false,"given":"Yuki","family":"Kaneda","sequence":"first","affiliation":[{"name":"Research Institute for Microbial Diseases The University of Osaka  Suita Osaka Japan"},{"name":"Graduate School of Pharmaceutical Sciences The University of Osaka  Suita Osaka 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