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Male fertility has become a growing global health concern, driven by the increasing prevalence of hypogonadism and associated infertility. The existing treatment options for reproductive diseases have not achieved complete success, which highlights the need to explore novel therapeutic approaches. The malfunction and\/or suppression of molecular regulators involved in the maintaining of cellular homeostasis under stress conditions have been identified as a key issue in Leydig cell insufficiency. miRNAs are noncoding RNA molecules that play a pivotal function in regulating gene expression and are implicated in diverse physiological and pathological conditions. In recent years, investigation into noncoding RNA\u2010mediated gene repression has revealed new perspectives into the pathogenesis of testosterone insufficiency, including mitochondrial dysfunction, inflammation, steroidogenic impairment, cellular proliferation, and apoptosis. 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