{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:04:24Z","timestamp":1793239464238,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100021092","name":"University of Yamanashi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021092","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity and low testosterone levels are closely interconnected, with the FTO gene being the most robust genetic determinant of body mass index (BMI). However, whether this primary genetic driver of obesity directly influences the hypothalamic\u2010pituitary\u2010testicular (HPT) axis remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this cross\u2010sectional study of 251 Japanese men, we performed genotyping for the FTO rs1558902 polymorphism. Anthropometric measurements (BMI and waist\u2010to\u2010hip ratio [WHR]), total testosterone (tT), free testosterone (fT), luteinizing hormone (LH), and follicle\u2010stimulating hormone (FSH) levels were assessed. Central obesity was defined as WHR \u2265 0.9.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The FTO A\u2010allele frequency was 35.9%. A\u2010allele carriers had significantly higher BMI than non\u2010carriers (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05), but no significant differences were found in tT or fT levels between genotypes. tT was inversely correlated with BMI and WHR (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). Men with central obesity exhibited significantly lower tT and fT levels alongside elevated LH and FSH levels (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Multivariate analysis confirmed that the FTO genotype was not independently associated with testosterone levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although the FTO rs1558902 polymorphism was associated with a higher BMI, it did not directly correlate with testosterone levels in Japanese men. This suggests that a genetic predisposition to obesity may not be a direct determinant of low testosterone levels. Instead, the observed elevation of gonadotropins in men with central obesity highlights the significant impact of age\u2010related testicular dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70261","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:45:16Z","timestamp":1779288316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between FTO rs1558902 Polymorphism, Age\u2010Related Hypogonadism, and Central Obesity in Japanese Men"],"prefix":"10.1111","author":[{"given":"Takahiro","family":"Tsutsumi","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology Graduate School of Interdisciplinary Research Faculty of Medicine University of Yamanashi  Chuo Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Okuma","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Graduate School of Interdisciplinary Research Faculty of Medicine University of Yamanashi  Chuo Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuminori","family":"Kazama","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory University of Yamanashi  Chuo Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masumi","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory University of Yamanashi  Chuo Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Takato","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory University of Yamanashi  Chuo Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Nara","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory University of Yamanashi  Chuo Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asako","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Kua\u2010house Isawa, Isawa Hot Spring Hospital  Fuefuki Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5273-4602","authenticated-orcid":false,"given":"Nozomi","family":"Harai","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Graduate School of Interdisciplinary Research Faculty of Medicine University of Yamanashi  Chuo Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2863-4561","authenticated-orcid":false,"given":"Kyoichiro","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Graduate School of Interdisciplinary Research Faculty of Medicine University of Yamanashi  Chuo Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"issue":"7","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/obr.12282","article-title":"Testosterone and Obesity","volume":"16","author":"Kelly D. 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