{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:22:02Z","timestamp":1790799722572,"version":"4.1.0"},"reference-count":157,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2024\u2010BSLH\u2010322"],"award-info":[{"award-number":["2024\u2010BSLH\u2010322"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Spermatogenesis is a highly energy\u2010dependent and tightly regulated differentiation process in the male reproductive system, characterized by dynamic, stage\u2010specific metabolic adaptations during spermatogonial proliferation, meiosis and sperm maturation. Accumulating evidence suggests that successful spermatogenesis is associated with a coordinated program of metabolic reprogramming, which involves the sequential and context\u2010dependent utilization of distinct bioenergetic pathways rather than dependence on a single energy source. Importantly, metabolic reprogramming represents a physiological and tightly controlled process, whereas metabolic dysfunction arises from its disruption or dysregulation. Studies using mouse models, supported by single\u2010cell omics and metabolic analyses, indicate stage\u2010associated transitions from glycolysis to oxidative phosphorylation (OXPHOS), followed by increased utilization of alternative substrates such as fatty acids and amino acids during germ cell development. These transitions are orchestrated by interconnected networks involving energy\u2010sensing pathways, endocrine regulation and metabolite\u2010driven epigenetic modifications. Disruption of this finely tuned metabolic reprogramming leads to metabolic dysfunction, characterized by oxidative stress, mitochondrial impairment, meiotic defects and chromatin instability, ultimately compromising spermatogenic homeostasis and contributing to idiopathic male infertility. Consistent evidence from experimental and clinical studies further suggests that systemic metabolic disorders, including obesity, diabetes, and dyslipidaemia, as well as exposure to endocrine\u2010disrupting chemicals, may impair metabolic coupling between Sertoli cells and germ cells, thereby exacerbating testicular metabolic imbalance. These disturbances exacerbate mitochondrial dysfunction, one\u2010carbon metabolic imbalance, and blood\u2013testis barrier (BTB) disruption, ultimately leading to reduced sperm quality and fertility. Building on these insights, we propose a metabolism\u2010centred classification framework that stratifies idiopathic male infertility into glycolysis\u2010impaired, OXPHOS\u2010deficient, lipid\u2010overload, and one\u2010carbon metabolism\u2013dysregulated subtypes. We further discuss the translational potential of targeting metabolic pathways through mitochondrial\u2010directed antioxidants, modulation of energy\u2010sensing signalling, and nutritional interventions. Finally, we highlight the need for future studies integrating in vivo metabolic imaging, testicular organoid models and non\u2010invasive seminal metabolomic biomarkers, alongside well\u2010designed clinical trials, to advance metabolism\u2010based precision diagnostics and therapeutics for male infertility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70276","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:45:19Z","timestamp":1781329519000},"page":"2032-2056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic Reprogramming in Male Infertility: Mechanistic Integration and Translational Perspectives From Mouse Models"],"prefix":"10.1111","volume":"14","author":[{"given":"Jinyue","family":"Rong","sequence":"first","affiliation":[{"name":"Center of Reproductive Medicine Shengjing Hospital of China Medical University  Shenyang China"},{"name":"Key Laboratory of Reproductive Dysfunction Diseases, and Fertility Remodeling of Liaoning Province  Shenyang China"},{"name":"NHC Key Laboratory of Advanced Reproductive Medicine and Fertility (China Medical University) National Health Commission Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Wang","sequence":"additional","affiliation":[{"name":"The Tenth General Surgery Department Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiming","family":"Yan","sequence":"additional","affiliation":[{"name":"The Tenth General Surgery Department Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichun","family":"Tan","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine Shengjing Hospital of China Medical University  Shenyang China"},{"name":"Key Laboratory of Reproductive Dysfunction Diseases, and Fertility Remodeling of Liaoning Province  Shenyang China"},{"name":"NHC Key Laboratory of Advanced Reproductive Medicine and Fertility (China Medical University) National Health Commission Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-5668","authenticated-orcid":false,"given":"Meng","family":"Dong","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine Shengjing Hospital of China Medical University  Shenyang China"},{"name":"Key Laboratory of Reproductive Dysfunction Diseases, and Fertility Remodeling of Liaoning Province  Shenyang China"},{"name":"NHC Key Laboratory of Advanced Reproductive Medicine and Fertility (China Medical University) National Health Commission Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0032-1"},{"issue":"1","key":"e_1_2_16_3_1","first-page":"36","article-title":"Diagnosis and Treatment of Infertility in Men: AUA\/ASRM Guideline Part I","volume":"205","author":"Schlegel P. N.","year":"2021","journal-title":"Journal Durologie"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-020-0183-x"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.12.006"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201899518"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1392241"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26031001"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-025-04541-w"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb46070381"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00626-7"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e38591"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells15030296"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-022-01034-w"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-23-0097"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2025.126231"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-015-0451-0"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2025.107967"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00074.2025"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-09094-5"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abq3173"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.593005"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioy198"},{"issue":"1","key":"e_1_2_16_24_1","first-page":"109","article-title":"mTORC1, the Maestro of Cell Metabolism and Growth","volume":"39","author":"He L.","year":"2025","journal-title":"Genes & Development"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000309"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.287045.116"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14110832"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.03.004"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.235937"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10010098"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108752"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2418693122"},{"issue":"6","key":"e_1_2_16_33_1","first-page":"545","article-title":"The Effect of Phoenix Dactylifera Pollen on the Expression of NRF2, SOD2, CAT, and GPX4 Genes, and Sperm Parameters of Fertile and Infertile Men: A Controlled Clinical Trial","volume":"19","author":"Fallahi S.","year":"2021","journal-title":"International Journal of Reproductive BioMedicine"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi053"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.135123"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407708101"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-08-0337"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.791277"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.026435"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7038124"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-020-00390-9"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2506417122"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-08775-5"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04693-6"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.02.012"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2012.77"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1079-1"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21325"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.1530\/ror.0.0040048"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3075"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.12.007"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2015.07.021"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10092331"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2020"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.03.003"},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3311"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1911"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/414799a"},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm788"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-20-0196"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22405"},{"key":"e_1_2_16_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2019.05.027"},{"key":"e_1_2_16_63_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.288167"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.023"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adf8822"},{"issue":"2","key":"e_1_2_16_66_1","first-page":"60","article-title":"Succinate Accumulation Links Mitochondrial MnSOD Depletion to Aberrant Nuclear DNA Methylation and Altered Cell Fate","volume":"1","author":"Cramer\u2010Morales K.","year":"2020","journal-title":"Journal of Experimental Pathology"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.10.020"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07472-3"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2025.04.015"},{"key":"e_1_2_16_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-020-00845-1"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-025-01454-4"},{"key":"e_1_2_16_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10050695"},{"key":"e_1_2_16_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26157544"},{"key":"e_1_2_16_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041998"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-024-00866-y"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-022-00918-x"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05010-3"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109025"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani15152246"},{"key":"e_1_2_16_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15050519"},{"issue":"3","key":"e_1_2_16_81_1","first-page":"10","article-title":"Sperm Mitochondrial Dysfunction and Oxidative Stress as Possible Reasons for Isolated Asthenozoospermia","volume":"69","author":"Nowicka\u2010Bauer K.","year":"2018","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_16_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1505213"},{"key":"e_1_2_16_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0305861"},{"key":"e_1_2_16_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani14243656"},{"key":"e_1_2_16_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-025-01458-0"},{"key":"e_1_2_16_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2023.159433"},{"key":"e_1_2_16_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/eep\/dvaa019"},{"key":"e_1_2_16_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49765-1"},{"key":"e_1_2_16_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-024-00952-1"},{"key":"e_1_2_16_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103669"},{"key":"e_1_2_16_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-025-01327-x"},{"key":"e_1_2_16_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-025-01974-9"},{"key":"e_1_2_16_93_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.108.006155"},{"key":"e_1_2_16_94_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84431"},{"key":"e_1_2_16_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2021.100543"},{"key":"e_1_2_16_96_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.775650"},{"key":"e_1_2_16_97_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1619"},{"key":"e_1_2_16_98_1","doi-asserted-by":"publisher","DOI":"10.4274\/jtgga.galenos.2024.2023-7-3"},{"key":"e_1_2_16_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2024.107567"},{"key":"e_1_2_16_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1520835"},{"key":"e_1_2_16_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073718"},{"key":"e_1_2_16_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.117465"},{"key":"e_1_2_16_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.02.022"},{"key":"e_1_2_16_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-28177-z"},{"key":"e_1_2_16_105_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja2024113"},{"key":"e_1_2_16_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-74658-0"},{"key":"e_1_2_16_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.09.008"},{"key":"e_1_2_16_108_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25075"},{"key":"e_1_2_16_109_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181115"},{"key":"e_1_2_16_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10020064"},{"key":"e_1_2_16_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-74180-8_10"},{"key":"e_1_2_16_112_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-9-227"},{"key":"e_1_2_16_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12956"},{"key":"e_1_2_16_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.105457"},{"key":"e_1_2_16_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00542-6"},{"key":"e_1_2_16_116_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.673258"},{"key":"e_1_2_16_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.23772"},{"key":"e_1_2_16_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04715-3"},{"key":"e_1_2_16_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2025.112658"},{"key":"e_1_2_16_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10320"},{"key":"e_1_2_16_121_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CB00091A"},{"key":"e_1_2_16_122_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.6b00115"},{"key":"e_1_2_16_123_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0311165"},{"key":"e_1_2_16_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-61939-z"},{"key":"e_1_2_16_125_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adn4508"},{"key":"e_1_2_16_126_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26167865"},{"key":"e_1_2_16_127_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10051115"},{"key":"e_1_2_16_128_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13479"},{"key":"e_1_2_16_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04474-0"},{"key":"e_1_2_16_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-95820-2"},{"key":"e_1_2_16_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.11.010"},{"key":"e_1_2_16_132_1","first-page":"627","article-title":"[Low\u2010level laser therapy for the treatment of male infertility and erectile dysfunction]","volume":"57","author":"Niu Y.","year":"2025","journal-title":"Beijing da Xue Xue Bao Yi Xue Ban = Journal of Peking University Health Sciences"},{"key":"e_1_2_16_133_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7216"},{"key":"e_1_2_16_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07813"},{"key":"e_1_2_16_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8176"},{"issue":"9","key":"e_1_2_16_136_1","first-page":"1314","article-title":"Nicotinamide Mononucleotide Improves Spermatogenic Function in Streptozotocin\u2010induced Diabetic Mice via Modulating the Glycolysis Pathway","volume":"54","author":"Ma D.","year":"2022","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"e_1_2_16_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.70162"},{"key":"e_1_2_16_138_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15224772"},{"key":"e_1_2_16_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.05.022"},{"key":"e_1_2_16_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-020-00096-0"},{"key":"e_1_2_16_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2024.101861"},{"issue":"1","key":"e_1_2_16_142_1","first-page":"705","article-title":"Characterization of Cholesterol Metabolism in Sertoli Cells and Spermatogenesis (Review)","volume":"17","author":"Shi J.","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_16_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01493-z"},{"key":"e_1_2_16_144_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1100747"},{"key":"e_1_2_16_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0345-z"},{"key":"e_1_2_16_146_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020689"},{"key":"e_1_2_16_147_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-19-0435"},{"key":"e_1_2_16_148_1","doi-asserted-by":"crossref","unstructured":"U.F\u00f6rstermannandW.Sessa \u201cNitric Oxide Synthases: Regulation and Function \u201dEuropean Heart Journal33 no.7(2012):829\u2013837 837a\u2013837d.","DOI":"10.1093\/eurheartj\/ehr304"},{"issue":"2","key":"e_1_2_16_149_1","first-page":"18","article-title":"The Role of Nitric Oxide on Male and Female Reproduction","volume":"29","author":"Dutta S.","year":"2022","journal-title":"Malays J Med Sci"},{"key":"e_1_2_16_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2019.01.034"},{"key":"e_1_2_16_151_1","doi-asserted-by":"publisher","DOI":"10.35629\/4494-0906324335"},{"key":"e_1_2_16_152_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac157"},{"key":"e_1_2_16_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2024.100904"},{"key":"e_1_2_16_154_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1256963"},{"key":"e_1_2_16_155_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-13-0311"},{"issue":"4","key":"e_1_2_16_156_1","first-page":"2471","article-title":"Aberrant Expression of SpermSpecific Glycolytic Enzymes Are Associated with Poor Sperm Quality","volume":"19","author":"Liu X.","year":"2019","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_16_157_1","doi-asserted-by":"crossref","unstructured":"U.Kumar D. V. S.Sudhakar andN.Kumar \u201cTEX13B is Essential for Metabolic Reprogramming during Germ Cell Differentiation \u201dHuman Reproduction(2024):deae094.","DOI":"10.1093\/humrep\/deae094"},{"key":"e_1_2_16_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04386-z"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.70276","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:31:07Z","timestamp":1789993867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.70276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,12]]},"references-count":157,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/andr.70276"],"URL":"https:\/\/doi.org\/10.1111\/andr.70276","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,12]]},"assertion":[{"value":"2026-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}