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Functional connectivity (FC) between dorsolateral prefrontal cortex (DLPFC) and subcallosal cingulate cortex (SCC) has been found to serve as neuroimaging biomarker for predicting SSRI treatment response. Despite the fact that altered FC has been observed in PE patients, the neural mechanisms underlying the rapid\u2010acting effects on brain of immediate\u2010term dapoxetine administration remain unknown. This study aimed to explore the mechanisms underlying this therapeutic effect based on DLPFC and SCC, which are involved in the regulation of ejaculatory reflex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Resting\u2010state functional magnetic resonance imaging and structural MRI data were acquired from a sample of 40 PE patients before and after immediate\u2010term dapoxetine administration, as well as 40 healthy controls (HCs). Seed\u2010based voxel\u2010wise FC analysis was performed, and whole\u2010brain FC values in regions of interest (ROIs) (bilateral SCC and DLPFC: spheres with 6\u00a0mm radius) were calculated. FC values of bilateral DLPFC and SCC were compared between PE patients before and after dapoxetine administration and HCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Using SCC as ROIs, treatment\u2010na\u00efve PE patients showed decreased FC within the default mode network (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.005) but increased FC with the attention network (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.005) compared to HCs. Following dapoxetine administration, the pattern of alterations compared to HCs changed, now additionally featuring decreased FC between the SCC and the visual network (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.005). Crucially, within\u2010patient comparisons revealed that dapoxetine administration significantly decreased FC between the SCC and both the attention network (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.005) and the visual network (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.005). In contrast, using DLPFC as ROIs revealed widespread hypocomnectivity in patients, which remained unchanged following acute administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The therapeutic effects of immediate\u2010term dapoxetine administration may act by downregulating FC of SCC and related circuits (promotional factors for PE), but do not enhance FC of DLPFC and related circuits (inhibition factors for PE). The latter may be achieved by long\u2010term dapoxetine administration or other long\u2010acting SSRI treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70333","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:29:12Z","timestamp":1785414552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immediate\u2010Term Dapoxetine Administration Suppressed Functional Connectivity of Subcallosal Cingulate Cortex in Premature Ejaculation: A Resting\u2010State fMRI Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9786-2585","authenticated-orcid":false,"given":"Jianhuai","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Andrology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology and Male Reproductive Medicine Luoyang Maternal and Child Health Hospital  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology Jiangsu Institute of Cancer Research Jiangsu Cancer Hospital The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Andrology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Andrology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Andrology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Andrology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Andrology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peining","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Andrology Siyang Traditional Chinese Medicine Hospital  Suqian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0389-4049","authenticated-orcid":false,"given":"Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Andrology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa150"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01181.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.05.017"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2006.00305.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.08.023"},{"issue":"7","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.neubiorev.2006.01.001","article-title":"Serotonin and the Neurobiology of the Ejaculatory Threshold","volume":"30","author":"De Jong T. 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