{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:34:30Z","timestamp":1786714470096,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1030123"],"award-info":[{"award-number":["1030123"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001786","name":"University of Adelaide","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Lower testosterone concentrations in older men are associated with poorer health outcomes.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n We examined whether, on a background of lifestyle intervention, testosterone treatment modulates leucocyte telomere length, a postulated marker of biological ageing, in overweight men with impaired glucose tolerance (IGT) or newly diagnosed type 2 diabetes (T2D).<\/jats:p>\n <\/jats:sec>\n \n Participants and Methods<\/jats:title>\n We conducted a secondary analysis of a randomised, placebo\u2010controlled trial in 50\u2010 to 74\u2010year\u2010old men with waist circumference \u2265\u00a095\u00a0cm and dysglycaemia (ACTRN12612000287831). All men received a background lifestyle program, and were randomised to 2 years treatment with intramuscular testosterone undecanoate (1000\u00a0mg) every 3 months or placebo. Leucocyte telomere length was assayed by multiplex quantitative polymerase chain reaction and expressed as relative telomere length (rTL), a ratio of telomeric DNA to \u03b2\u2010globin, a single\u2010copy control gene (T\/S ratio).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were 720 participants, aged 60\u00a0\u00b1\u00a06 years (mean\u00a0\u00b1\u00a0SD), 38% had BMI 30\u201334.99\u00a0kg\/m\n 2<\/jats:sup>\n and 44% \u2265\u00a035\u00a0kg\/m\n 2<\/jats:sup>\n . Mean rTL at baseline was 1.63\u00a0\u00b1\u00a00.27 in testosterone\u2010treated men (\n N<\/jats:italic>\n = 375) and 1.61\u00a0\u00b1\u00a00.28 in placebo\u2010treated men (\n N<\/jats:italic>\n = 345). At 2 years, mean rTL was 1.61\u00a0\u00b1\u00a00.28 and 1.58\u00a0\u00b1 0.29, respectively. Change in rTL after 2 years treatment was \u22120.02\u00a0\u00b1\u00a00.15 in testosterone\u2010treated and \u22120.03\u00a0\u00b1\u00a00.12 in placebo\u2010treated men. Adjusting for baseline values there was no effect of testosterone treatment on rTL at 2 years (mean difference 0.01 [95% CI, \u22120.01 to 0.03],\n p<\/jats:italic>\n = 0.24). Results were similar for rTL change at 2 years from baseline.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n There was no effect of testosterone treatment on telomere length in this group of men. Larger studies with longer treatment durations are merited.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/andr.70348","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:56:41Z","timestamp":1786712201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Testosterone Treatment on Leucocyte Telomere Length in Men: Results From a Randomised Placebo\u2010Controlled Trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7612-5892","authenticated-orcid":false,"given":"Bu B.","family":"Yeap","sequence":"first","affiliation":[{"name":"Medical School University of Western Australia Perth Australia"},{"name":"Department of Endocrinology and Diabetes Fiona Stanley Hospital Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1653-2496","authenticated-orcid":false,"given":"Jennie","family":"Hui","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine Sir Charles Gairdner Hospital Perth Australia"},{"name":"School of Population and Global Health University of Western Australia Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0213-7652","authenticated-orcid":false,"given":"Kristy P.","family":"Robledo","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7613-1562","authenticated-orcid":false,"given":"Gillian","family":"Arscott","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine Sir Charles Gairdner Hospital Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8261-3457","authenticated-orcid":false,"given":"Mathis","family":"Grossmann","sequence":"additional","affiliation":[{"name":"Department of Medicine (Austin Health) University of Melbourne Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4200-7476","authenticated-orcid":false,"given":"David J.","family":"Handelsman","sequence":"additional","affiliation":[{"name":"ANZAC Research Institute University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5078-4980","authenticated-orcid":false,"given":"Warrick J.","family":"Inder","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Princess Alexandra Hospital Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9109-9864","authenticated-orcid":false,"given":"Bronwyn G. A.","family":"Stuckey","sequence":"additional","affiliation":[{"name":"Medical School University of Western Australia Perth Australia"},{"name":"Keogh Institute for Medical Research Perth Australia"},{"name":"Department of Endocrinology and Diabetes Sir Charles Gairdner Hospital Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0583-3717","authenticated-orcid":false,"given":"Alicia J.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre University of Sydney Sydney Australia"},{"name":"Baker Heart and Diabetes Research Institute Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6085-445X","authenticated-orcid":false,"given":"Karen","family":"Bracken","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Beilby","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences University of Western Australia Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6818-6065","authenticated-orcid":false,"given":"Gary A.","family":"Wittert","sequence":"additional","affiliation":[{"name":"Freemasons Centre for Male Health and Wellbeing University of Adelaide Adelaide Australia"},{"name":"Department of Endocrinology and Diabetes Royal Adelaide Hospital Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.7326\/M23-0342","article-title":"Factors Associated With Circulating Sex Hormones in Men: Individual Participant Data Meta\u2010Analyses","volume":"176","author":"Marriott R. 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