{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:27:46Z","timestamp":1786714066762,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371635"],"award-info":[{"award-number":["82371635"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2023AH053308"],"award-info":[{"award-number":["2023AH053308"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Erectile dysfunction (ED) is a prevalent male health disorder and a recognized sentinel marker for cardiovascular disease. Current diagnostic reliance on subjective questionnaires or invasive examinations limits early screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We aimed to develop and validate a machine learning model based on routine blood test data to predict ED risk to facilitate its early clinical screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from 4116 men in the NHANES database (2001\u20132004) formed the training\/internal validation sets. An independent external validation set comprised 489 clinical patients with NPTR\u2010confirmed ED. From 49 initial demographic and blood\u2010based indicators, feature selection via univariate logistic, multivariate logistic, and LASSO regression identified nine key predictors. Seven machine learning models were constructed, optimized via grid search with fivefold cross\u2010validation, and evaluated using ROC analysis, calibration curves, and decision curve analysis (DCA). The optimal model was interpreted via SHAP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The random forest model achieved superior performance, with an external validation AUC of 0.934, accuracy of 0.918, and specificity of 0.986, significantly outperforming logistic regression (AUC = 0.743). SHAP analysis identified age, sex hormone\u2010binding globulin (SHBG), testosterone, glucose, cholesterol, and creatinine as the most influential predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The study established a concise, nine\u2010feature blood test panel and validated a high\u2010performing predictive model in an independent clinical cohort, demonstrating significant clinical net benefit. Meanwhile, this model provides an economical, non\u2010invasive, and scalable screening tool suitable for health check\u2010ups, facilitating early ED identification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A machine learning model based on routine blood tests can effectively evaluate ED risk, offering a novel foundation for early screening and precision management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70358","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:32:12Z","timestamp":1786710732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Erectile Dysfunction From Routine Blood Test Data: Development and Validation of a Machine Learning\u2010Based Prediction Model"],"prefix":"10.1111","author":[{"given":"Peng","family":"Yang","sequence":"first","affiliation":[{"name":"Anhui Medical University  Hefei China"},{"name":"The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukuai","family":"Ma","sequence":"additional","affiliation":[{"name":"Anhui Medical University  Hefei China"},{"name":"The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Cao","sequence":"additional","affiliation":[{"name":"Anhui Medical University  Hefei China"},{"name":"The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui Medical University  Hefei China"},{"name":"The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Ge","sequence":"additional","affiliation":[{"name":"Anhui Medical University  Hefei China"},{"name":"The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianle","family":"Zhu","sequence":"additional","affiliation":[{"name":"Urology and Nephrology Center Department of Urology Zhejiang Provincial People's Hospital Affiliated People's Hospital Hangzhou Medical College  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Gao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6003-5182","authenticated-orcid":false,"given":"Xiansheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui Medical University  Hefei China"},{"name":"The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jsxm.2015.12.019","article-title":"Definitions of Sexual Dysfunctions in Women and Men: A Consensus Statement From the Fourth International Consultation on Sexual Medicine 2015","volume":"13","author":"McCabe M. P.","year":"2016","journal-title":"Journal of Sexual Medicine"},{"issue":"3","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.sxmr.2018.01.001","article-title":"Erectile Dysfunction and Subclinical Cardiovascular Disease","volume":"7","author":"Miner M.","year":"2019","journal-title":"Sexual Medicine Reviews"},{"issue":"3","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/sxmrev\/qeaf014","article-title":"Understanding the Erectile Dysfunction\u2010Cardiovascular Disease Connection: Clinical and Pathophysiological Insights","volume":"13","author":"An J.","year":"2025","journal-title":"Sexual Medicine Reviews"},{"issue":"1","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1743-6109.2009.01624.x","article-title":"Anatomy, Physiology, and Pathophysiology of Erectile Dysfunction","volume":"7","author":"Gratzke C.","year":"2010","journal-title":"Journal of Sexual Medicine"},{"issue":"5","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.eururo.2013.08.023","article-title":"A Systematic Review of the Association Between Erectile Dysfunction and Cardiovascular Disease","volume":"65","author":"Gandaglia G.","year":"2014","journal-title":"European Urology"},{"issue":"5","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.eururo.2013.11.013","article-title":"Do Erectile Dysfunction and Cardiovascular Disease Have the Same Mechanism?","volume":"65","author":"Keenan H. A.","year":"2014","journal-title":"European Urology"},{"issue":"2","key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1023\/B:UROL.0000034671.66707.fa","article-title":"Erectile Dysfunction Rates and Requests for Treatment in Patients Attending Outpatient Urology Clinics and Those Accompanying Them","volume":"36","author":"Kuru A. F.","year":"2004","journal-title":"International Urology and Nephrology"},{"issue":"2","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11934-022-01135-4","article-title":"A Review on Penile Doppler and Ultrasonography for Erectile Dysfunction","volume":"24","author":"Elgendi K.","year":"2023","journal-title":"Current Urology Reports"},{"issue":"7","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41443-023-00789-z","article-title":"Nocturnal Penile Tumescence Devices: Past, Present and Future","volume":"36","author":"Schardein J. N.","year":"2024","journal-title":"International Journal of Impotence Research"},{"issue":"7","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1111\/j.1743-6109.2009.01343.x","article-title":"Use and Abuse of Rigiscan in the Diagnosis of Erectile Dysfunction","volume":"6","author":"Jannini E. A.","year":"2009","journal-title":"Journal of Sexual Medicine"},{"issue":"4","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/CM9.0000000000000099","article-title":"Dynamic Infusion Cavernosometry and Cavernosography for Classifying Venous Erectile Dysfunction and Its Significance for Individual Treatment","volume":"132","author":"Gao Q.","year":"2019","journal-title":"Chinese Medical Journal"},{"issue":"1","key":"e_1_2_11_13_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-66667-w","article-title":"Association of the Hemoglobin, Albumin, Lymphocyte, and Platelet Score With the Risk of Erectile Dysfunction: A Cross\u2010Sectional Study","volume":"14","author":"Chen D.","year":"2024","journal-title":"Scientific Reports"},{"issue":"12","key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.numecd.2018.08.006","article-title":"Is Lower Low\u2010Density Lipoprotein Cholesterol Associated With Lower Androgen and Erectile Dysfunction in Men?","volume":"28","author":"Chen C.","year":"2018","journal-title":"Nutrition, Metabolism, and Cardiovascular Diseases: NMCD"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.101934","article-title":"Development and Validation of an Insulin Resistance Model for a Population Without Diabetes Mellitus and Its Clinical Implication: A Prospective Cohort Study","volume":"58","author":"Tsai S.","year":"2023","journal-title":"EClinicalMedicine"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","DOI":"10.1038\/srep43381","article-title":"Computational Methods Using Genome\u2010Wide Association Studies to Predict Radiotherapy Complications and to Identify Correlative Molecular Processes","volume":"7","author":"Oh J. H.","year":"2017","journal-title":"Scientific Reports"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.105458","article-title":"Machine Learning in Medical Applications: A Review of State\u2010of\u2010the\u2010Art Methods","volume":"145","author":"Shehab M.","year":"2022","journal-title":"Computers in Biology and Medicine"},{"issue":"13","key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"5842","DOI":"10.7150\/ijbs.120980","article-title":"Metabolic Syndrome\u2010Associated Erectile Dysfunction: Multiple Vascular Endothelial Dysfunction Mechanisms and Potential Therapeutic Targets","volume":"21","author":"Wang H.","year":"2025","journal-title":"International Journal of Biological Sciences"},{"issue":"8","key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.3390\/cimb46080521","article-title":"Oxidative Stress and Erectile Dysfunction: Pathophysiology, Impacts, and Potential Treatments","volume":"46","author":"Kaltsas A.","year":"2024","journal-title":"Current Issues in Molecular Biology"},{"issue":"2","key":"e_1_2_11_20_1","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3494","article-title":"Erectile Dysfunction and Diabetes: A Melting Pot of Circumstances and Treatments","volume":"38","author":"Defeudis G.","year":"2022","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"issue":"3","key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/andr.13507","article-title":"Evaluation of Androgen Receptor Markers in Erectile Dysfunction","volume":"12","author":"Khodamoradi K.","year":"2024","journal-title":"Andrology"},{"issue":"8","key":"e_1_2_11_22_1","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.1363","article-title":"Association Between the Systemic Immune\u2010Inflammation Index and Erectile Dysfunction: A Cross\u2010Sectional Study","volume":"12","author":"Chen D.","year":"2024","journal-title":"Immunity, Inflammation and Disease"},{"issue":"2","key":"e_1_2_11_23_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.fertnstert.2016.12.018","article-title":"Effects of Age on Fertility and Sexual Function","volume":"107","author":"Eisenberg M. L.","year":"2017","journal-title":"Fertility and Sterility"},{"issue":"5","key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1080\/13685538.2019.1686756","article-title":"Aging and Erectile Function","volume":"23","author":"Meldrum D. R.","year":"2020","journal-title":"The Aging Male: The Official Journal of the International Society for the Study of the Aging Male"},{"issue":"10","key":"e_1_2_11_25_1","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1111\/j.1743-6109.2012.02869.x","article-title":"Is Erectile Dysfunction a Reliable Proxy of General Male Health Status? The Case for the International Index of Erectile Function\u2010Erectile Function Domain","volume":"9","author":"Salonia A.","year":"2012","journal-title":"Journal of Sexual Medicine"},{"issue":"2","key":"e_1_2_11_26_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1210\/clinem\/dgad484","article-title":"Effect of Testosterone Replacement Therapy on Sexual Function and Hypogonadal Symptoms in Men With Hypogonadism","volume":"109","author":"Pencina K. M.","year":"2024","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"10","key":"e_1_2_11_27_1","doi-asserted-by":"crossref","first-page":"E1577","DOI":"10.1210\/jc.2010-2216","article-title":"The Relationships Between Sex Hormones and Sexual Function in Middle\u2010aged and Older European Men","volume":"96","author":"O'Connor D. B.","year":"2011","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_11_28_1","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1335146","article-title":"An Updated Systematic Review and Meta\u2010Analysis of the Effects of Testosterone Replacement Therapy on Erectile Function and Prostate","volume":"15","author":"Xu Z.","year":"2024","journal-title":"Frontiers in Endocrinology"},{"issue":"11","key":"e_1_2_11_29_1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00018-022-04562-1","article-title":"Role of Sex Hormone\u2010Binding Globulin in the Free Hormone Hypothesis and the Relevance of Free Testosterone in Androgen Physiology","volume":"79","author":"Narinx N.","year":"2022","journal-title":"Cellular and Molecular Life Sciences: CMLS"},{"issue":"4","key":"e_1_2_11_30_1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.sxmr.2019.02.005","article-title":"Testosterone Deficiency and Endothelial Dysfunction: Nitric Oxide, Asymmetric Dimethylarginine, and Endothelial Progenitor Cells","volume":"7","author":"Hotta Y.","year":"2019","journal-title":"Sexual Medicine Reviews"},{"issue":"6","key":"e_1_2_11_31_1","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1111\/andr.12866","article-title":"Testosterone Positively Regulates Functional Responses and Nitric Oxide Expression in the Isolated Human Corpus Cavernosum","volume":"8","author":"Gur S.","year":"2020","journal-title":"Andrology"},{"issue":"4","key":"e_1_2_11_32_1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/cen.13530","article-title":"Sex Hormone\u2010Binding Globulin Is Associated With Androgen Deficiency Features Independently of Total Testosterone","volume":"88","author":"Rastrelli G.","year":"2018","journal-title":"Clinical Endocrinology"},{"key":"e_1_2_11_33_1","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1359255","article-title":"Endothelial Dysfunction in Vascular Complications of Diabetes: A Comprehensive Review of Mechanisms and Implications","volume":"15","author":"Yang D.","year":"2024","journal-title":"Frontiers in Endocrinology"},{"issue":"1","key":"e_1_2_11_34_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-02458-1","article-title":"Potential Utility of the Triglyceride\u2010Glucose Index as a Predictor of Erectile Dysfunction and Its Severity: A Cross\u2010Sectional, Case\u2010Control Study","volume":"15","author":"Ates H. A.","year":"2025","journal-title":"Scientific Reports"},{"issue":"3","key":"e_1_2_11_35_1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s12020-023-03653-8","article-title":"The Association Between Lipid Parameters and Erectile Dysfunction: A Two\u2010Sample Mendelian Randomization and Case\u2010Control Study","volume":"84","author":"Ke M.","year":"2024","journal-title":"Endocrine"},{"issue":"7","key":"e_1_2_11_36_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.tjpad.2025.100190","article-title":"Association of the Difference Between Cystatin C\u2010 and Creatinine\u2010Based Estimated Glomerular Filtration Rate With Cerebral Small Vessel Disease: A Large Prospective Cohort Study","volume":"12","author":"Li Z.","year":"2025","journal-title":"Journal of Prevention of Alzheimer's Disease"},{"issue":"1","key":"e_1_2_11_37_1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1186\/s12872-025-05131-7","article-title":"Endothelial Activation and Stress Index and Cardiovascular Disease Among American Population\u2010Findings From NHANES 1999\u20132018","volume":"25","author":"Liu W.","year":"2025","journal-title":"BMC Cardiovascular Disorders"},{"issue":"9","key":"e_1_2_11_38_1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.040050","article-title":"Association Between the Serum Creatinine to Cystatin C Ratio and Cardiovascular Disease in Middle\u2010Aged and Older Adults in China: A Nationwide Cohort Study","volume":"14","author":"Chen J.","year":"2025","journal-title":"Journal of the American Heart Association"},{"issue":"6","key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1590\/S0100-879X2008005000026","article-title":"Effects of Acid\u2010Base Imbalance on Vascular Reactivity","volume":"41","author":"Celotto A. C.","year":"2008","journal-title":"Brazilian Journal of Medical and Biological Research = Revista brasileira de pesquisas medicas e biologica"},{"issue":"5","key":"e_1_2_11_40_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062887","article-title":"The Effect of Extracellular pH Changes on Intracellular pH and Nitric Oxide Concentration in Endothelial and Smooth Muscle Cells From Rat Aorta","volume":"8","author":"Capellini V. K.","year":"2013","journal-title":"PLoS ONE"},{"issue":"24","key":"e_1_2_11_41_1","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1113\/JP281517","article-title":"Acid\u2010Base Balance and Cerebrovascular Regulation","volume":"599","author":"Caldwell H. G.","year":"2021","journal-title":"Journal of Physiology"},{"issue":"6","key":"e_1_2_11_42_1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/1010-7940(92)90146-O","article-title":"Effect of Differing Acid\u2010Base Regulation on Cerebral Blood Flow Autoregulation During Cardiopulmonary Bypass","volume":"6","author":"Patel R. L.","year":"1992","journal-title":"European Journal of Cardio\u2010Thoracic Surgery: Official Journal of the European Association for Cardio\u2010Thoracic Surgery"},{"issue":"5","key":"e_1_2_11_43_1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.numecd.2018.01.013","article-title":"Serum Calcium Levels Independently Predict In\u2010Hospital Mortality in Patients With Acute Myocardial Infarction","volume":"28","author":"Shiyovich A.","year":"2018","journal-title":"Nutrition, Metabolism, and Cardiovascular Diseases: NMCD"},{"issue":"5","key":"e_1_2_11_44_1","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/jch.13532","article-title":"Borderline High Serum Calcium Levels Are Associated With Arterial Stiffness and 10\u2010Year Cardiovascular Disease Risk Determined by Framingham Risk Score","volume":"21","author":"Park B.","year":"2019","journal-title":"Journal of Clinical Hypertension"},{"issue":"10","key":"e_1_2_11_45_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111269","article-title":"Immunization Associated With Erectile Dysfunction Based on Cross\u2010Sectional and Genetic Analyses","volume":"9","author":"Chen Y.","year":"2014","journal-title":"PLoS ONE"},{"issue":"3","key":"e_1_2_11_46_1","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1007\/s10753-020-01384-w","article-title":"Tadalafil Alleviates LPS\u2010Induced Inflammation and Oxidative Stress of RWPE\u20101 Cell by Regulating the Akt\/Nrf2 Signaling Pathway","volume":"44","author":"Song X.","year":"2021","journal-title":"Inflammation"},{"issue":"1","key":"e_1_2_11_47_1","doi-asserted-by":"crossref","first-page":"9223","DOI":"10.1038\/s41598-023-36514-5","article-title":"In\u2010Vitro and In\u2010Silico Evidence for Oxidative Stress as Drivers for RDW","volume":"13","author":"Joosse H.","year":"2023","journal-title":"Scientific Reports"},{"issue":"1","key":"e_1_2_11_48_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s10753-022-01718-w","article-title":"The Pathogenic Role of Oxidative Stress, Cytokine Expression, and Impaired Hematological Indices in Diabetic Cardiovascular Diseases","volume":"46","author":"Saad H.","year":"2023","journal-title":"Inflammation"},{"key":"e_1_2_11_49_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.yjmcc.2022.04.011","article-title":"Targeting Endothelial Dysfunction and Inflammation","volume":"168","author":"Wang L.","year":"2022","journal-title":"Journal of Molecular and Cellular Cardiology"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70358","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.70358","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:32:21Z","timestamp":1786710741000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.70358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":48,"alternative-id":["10.1111\/andr.70358"],"URL":"https:\/\/doi.org\/10.1111\/andr.70358","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,14]]},"assertion":[{"value":"2026-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"andr.70358"}}