{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:17:51Z","timestamp":1788419871686,"version":"build-2803163510"},"reference-count":85,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["182300410336"],"award-info":[{"award-number":["182300410336"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nonorganic erectile dysfunction (nonorganic ED) is a common subtype of ED characterized by impaired erectile function in the absence of identifiable organic causes. Although ED is increasingly recognized as a multidimensional condition involving interacting biological, psychological, relational, and sociocultural factors, how these influences are integrated within central neural systems in nonorganic ED remains incompletely understood. Objective neurobiological markers are therefore still lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate whether patients with nonorganic ED exhibit abnormalities in local intrinsic brain activity and to examine the association between these alterations and erectile function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Resting\u2010state functional magnetic resonance imaging data were acquired from 29 patients with nonorganic ED and 29 age\u2010matched healthy controls. Regional homogeneity (ReHo) was used to assess local synchronization of spontaneous neural activity across the whole brain. Between\u2010group differences were evaluated using voxel\u2010wise analysis. Correlation analyses were performed to assess associations between altered ReHo and erectile function as measured by the International Index of Erectile Function (IIEF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with healthy controls, patients with nonorganic ED exhibited significantly decreased ReHo in the right anterior insula (family\u2010wise error corrected). Furthermore, reduced ReHo in this region was significantly associated with greater ED severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings indicate that nonorganic ED is associated with disrupted local functional coherence in the anterior insula, a key region involved in integrating interoceptive, emotional, cognitive, and autonomic processes. The observed association with erectile function suggests that impaired integration of these processes may contribute to the central neural mechanisms underlying nonorganic ED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with nonorganic ED exhibit reduced local functional coherence in the anterior insula, which is associated with ED severity. These findings provide preliminary evidence linking central neural dysfunction to clinical symptoms and support the further evaluation of resting\u2010state fMRI metrics as candidate neurobiological markers for nonorganic ED.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70373","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:01:05Z","timestamp":1788418865000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered Functional Coherence of the Right Anterior Insula in Men With Nonorganic Erectile Dysfunction: A Resting\u2010State fMRI Study"],"prefix":"10.1111","author":[{"given":"YuXin","family":"Bai","sequence":"first","affiliation":[{"name":"Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education School of Life Science and Technology Xidian University  Xi'an Shaanxi China"},{"name":"Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans\u2010Scale Life Information School of Life Science and Technology Xidian University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilu","family":"Chai","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education School of Life Science and Technology Xidian University  Xi'an Shaanxi China"},{"name":"Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans\u2010Scale Life Information School of Life Science and Technology Xidian University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Disease Henan Provincial People's Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Andrology Henan Provincial People's Hospital, People's Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9699-9466","authenticated-orcid":false,"given":"Janniko R.","family":"Georgiadis","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Groningen University Medical Centre Groningen (UMCG)  Groningen the Netherlands"},{"name":"School of Medicine and Health Sciences Carl Von Ossietzky University Oldenburg  Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangsheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Andrology Henan Provincial People's Hospital, People's Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0190-6985","authenticated-orcid":false,"given":"Minghao","family":"Dong","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education School of Life Science and Technology Xidian University  Xi'an Shaanxi China"},{"name":"Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans\u2010Scale Life Information School of Life Science and Technology Xidian University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.05.004"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743\u20106109.2008.00773.x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2021.08.009"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jsxmed\/qdaf332"},{"key":"e_1_2_13_7_1","first-page":"113","volume-title":"The Canary in the Coalmine: Erectile Dysfunction as the Best Biomarker of Non\u2010Communicable Chronic Diseases","author":"Jannini E. 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