{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T07:12:37Z","timestamp":1788592357113,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The brain plays a critical role in premature ejaculation (PE), but the specific regions involved remain unclear. This study aimed to identify functional brain network alterations in PE\u2010like rats and investigate the modulatory effects of electroacupuncture (EA) at SP6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixteen male Sprague\u2010Dawley rats were divided into PE\u2010like (\n                      <jats:italic>n<\/jats:italic>\n                      = 8) and control (\n                      <jats:italic>n<\/jats:italic>\n                      = 8) groups based on ejaculation frequency (EF). Copulatory behavior (EF, ejaculation latency [EL]), resting\u2010state fMRI, and plasma norepinephrine (NE) were assessed at baseline and after 4 weeks of daily EA at SP6. Functional brain networks were constructed using graph theory, and nodal measures were compared between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PE\u2010like rats exhibited significantly shortened EL and elevated plasma NE. Global network measures did not differ between groups. However, PE\u2010like rats showed: (1) decreased nodal strength and betweenness centrality in hypothalamus; (2) decreased betweenness centrality in retrosplenial granular cortex zone a\/postsubiculum; (3) increased clustering coefficient and global efficiency in RSD\/RSGa; (4) decreased local efficiency in primary somatosensory and dorsal thalamic nucleus. EF and NE were negatively associated with dorsal thalamic nucleus local efficiency, while EL was negatively associated with hypothalamus strength and betweenness centrality. EA treatment significantly reduced EF and NE, prolonged EL, and normalized most nodal abnormalities; the improvement in dorsal thalamic nucleus local efficiency survived FDR correction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PE\u2010like behavior in rats is associated with specific nodal alterations in hypothalamus, thalamus, and somatosensory cortex, alongside elevated NE. EA at SP6 was associated with partial normalization of these abnormalities, suggesting potential neuromodulatory mechanisms for PE, though causal relationships require further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70374","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:44:16Z","timestamp":1788590656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electroacupuncture at SP6 Modulates Functional Brain Networks and Reduces Plasma Norepinephrine to Ameliorate Premature Ejaculation in Rats"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2591-1295","authenticated-orcid":false,"given":"Ning","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Urology and Male Reproductive Medicine Luoyang Maternal and Child Health Hospital  Luoyang China"},{"name":"Department of Urology The People's Hospital of Jiaozuo  Jiaozuo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Andrology Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Urology The Second People's Hospital of Hefei Hefei Hospital Affiliated to Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutian","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Andrology Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Urology and Male Reproductive Medicine Luoyang Maternal and Child Health Hospital  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Luoyang Maternal and Child Health Hospital  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinggui","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Urology The People's Hospital of Jiaozuo  Jiaozuo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhuai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Andrology Jiangsu Province Hospital\u00a0of Chinese Medicine Affiliated Hospital of Nanjing University\u00a0of\u00a0Chinese\u00a0Medicine  Nanjing 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