{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:45:47Z","timestamp":1792035947825,"version":"4.4.0"},"reference-count":223,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male fertility in other ways and are prescribed much more often compare with cytotoxic treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Based on our review published in 2017, we systematically reviewed the effects of common medications on male fertility to provide evidence\u2010based recommendations for clinical management and possible fertility preservation in men of reproductive age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A systematic review of the literature using the PRISMA 2020 methodology was performed. We included only original studies published from 2016 to 2025 that involved human males exposed to noncytotoxic pharmacological treatments and reported outcomes related to male fertility, including spermatogenesis, semen parameters, and reproductive hormone concentrations. The data were synthesized descriptively and organized by pharmacological class and individual drug.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 16,310 studies retrieved, 184 were included. In addition to the studies describing the deleterious effects of testosterone, sulfasalazine, anabolic steroids, cyproterone acetate, opioids, sertraline, tramadol, GnRH analogues, and sartan that have already been included in the 2017 review, we focused on new studies with good\u2010 to high\u2010level evidence for the harmful effects of drugs such as duloxetine, thiopurines, dutasteride, valganciclovir, efavirenz, valproate, or hydroxyurea on male hormones and\/or fertility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this updated review, evidence\u2010based recommendations for clinical management and for possible fertility preservation or contraception in men of reproductive age receiving common acute or chronic medical treatment are provided, with the goal of making these data more readily available to medical staff.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70381","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:15:41Z","timestamp":1789204541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Common Medications on Male Fertility: An Updated Systematic Review"],"prefix":"10.1111","author":[{"given":"Lina","family":"Jebli","sequence":"first","affiliation":[{"name":"Laboratory of Reproductive Biology\u2010CECOS, Clinical\u2010Biological Centre of Assisted Reproductive Medicine, Hopitaux Universitaires de Marseille La Conception University Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1182-7085","authenticated-orcid":false,"given":"Salom\u00e9","family":"Gallissian","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology\u2010CECOS, Clinical\u2010Biological Centre of Assisted Reproductive Medicine, Hopitaux Universitaires de Marseille La Conception University Hospital  Marseille France"},{"name":"ADES, UMR 7268 Aix Marseille Universit\u00e9  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxanne","family":"Bar\u00e8ges","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology\u2010CECOS, Clinical\u2010Biological Centre of Assisted Reproductive Medicine, Hopitaux Universitaires de Marseille La Conception University Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8391-4725","authenticated-orcid":false,"given":"F\u00e9licia","family":"Fournier","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology\u2010CECOS, Clinical\u2010Biological Centre of Assisted Reproductive Medicine, Hopitaux Universitaires de Marseille La Conception University Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1971-1932","authenticated-orcid":false,"given":"Catherine","family":"Metzler\u2010Guillemain","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology\u2010CECOS, Clinical\u2010Biological Centre of Assisted Reproductive Medicine, Hopitaux Universitaires de Marseille La Conception University Hospital  Marseille France"},{"name":"Inserm, MMG, U1251 Aix Marseille Universit\u00e9  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8590-5452","authenticated-orcid":false,"given":"S\u00e9gol\u00e8ne","family":"Prades","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology\u2010CECOS, Clinical\u2010Biological Centre of Assisted Reproductive Medicine, Hopitaux Universitaires de Marseille La Conception University Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Magnan\u2010Sebag","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology\u2010CECOS, Clinical\u2010Biological Centre of Assisted Reproductive Medicine, Hopitaux Universitaires de Marseille La Conception University Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8198-4886","authenticated-orcid":false,"given":"Jeanne","family":"Perrin","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology\u2010CECOS, Clinical\u2010Biological Centre of Assisted Reproductive Medicine, Hopitaux Universitaires de Marseille La Conception University Hospital  Marseille France"},{"name":"IMBE, CNRS, IRD Aix Marseille Univ, Avignon University Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO\u201024\u201002782"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12366"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101740"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7120"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12811"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioaa130"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2021.105926"},{"issue":"4","key":"e_1_2_12_9_1","first-page":"481","article-title":"Comparison of Semen Analysis Parametes Changes after Priscription of Two Immunosuppresive Drugs, Tacrolimus and Cyclosporine in Men Undergoing Renal Transplantation","volume":"6","author":"Ramouz A.","year":"2016","journal-title":"Journal of Advanced Biomedical Sciences"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.02.415"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ard.2025.02.023"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41191"},{"key":"e_1_2_12_13_1","unstructured":"Le CRAT accessed March 20 2026 https:\/\/www.lecrat.fr\/."},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac551"},{"key":"e_1_2_12_15_1","volume-title":"Semen Analysis of Renal Transplant Patients Undergoing Immunosuppressive Treatment","author":"Moodley N. S.","year":"2017"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010020\u201002115\u2010x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/03915603221114612"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.07.008"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530319666190313112110"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16984"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjy198"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.180588"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14364"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010024\u201003520\u20100"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjac115"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.057"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.02.044"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmx034"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjy086"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab205"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard\u20102023\u2010224032"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569527.2024.2360736"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.85787"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.02.025"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.05.005"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.09.006"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.02.041"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/13524585211009208"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae609"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard\u20102023\u2010224017"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.14309\/01.ajg.0001034984.85288.1f"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2019.07.016"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00232"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2018.1449251"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.70001"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.04.031"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1534975"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2020.101488"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13546"},{"issue":"4","key":"e_1_2_12_50_1","first-page":"1565","article-title":"Post Interferon Therapy Decreases Male Fertility Through Gonadotoxic Effect","volume":"31","author":"Bukhari S. A.","year":"2018","journal-title":"Pakistan Journal of Pharmaceutical Sciences"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.202300616"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13788"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.21608\/ejvs.2024.273465.1882"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.2439"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2022.05.026"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.18502\/ijrm.v20i10.12267"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2024.100963"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2025.02.001"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010018\u20101330\u20102"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2022.842565"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.12717\/DR.2023.27.1.25"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010022\u201003390\u20103"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mefs.2017.06.001"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2019.12.007"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13633"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2024.2343758"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2025.2584688"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19251"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523\u2010017\u20100521\u20106"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13808"},{"key":"e_1_2_12_71_1","unstructured":"L.Rosado E.Simone C.Dicker et\u00a0al. \u201cCase Report and Review of Preclinical Studies: Successfully Fathering a Child Following Avapritinib for Indolent Systemic Mastocytosis\u201d. Physician and Investigator Conference May 18\u201319 2024."},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010020\u20100776\u20102"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.4103\/jopsys.jopsys_83_24"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13026"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2020.1752003"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.4314\/aja.v12i3.6"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.18502\/ijrm.v22i7.16971"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.5935\/1518\u20100557.20210110"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010022\u201006274\u20107"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.21123\/bsj.2020.17.1.0001"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010020\u201002219\u20102"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.33589\/32.4.130"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_72_22"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2021.1959506"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378\u20106323.177432"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.5653\/cerm.2024.07675"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2020.01.027"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4518"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2025.114771"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2019.05.016"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.70013"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.4103\/jhrs.jhrs_90_23"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279\u2010017\u20100709\u2010z"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.14576"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.09.016"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.11.015"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xfre.2021.06.002"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xfre.2025.03.002"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmae036"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2019.06.034"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2018.07.023"},{"key":"e_1_2_12_102_1","unstructured":"\u201cTransidentit\u00e9\u00a0: prise en charge de l'adulte Haute Autorit\u00e9 de Sant\u00e9 \u201d Accessed March 27 2026 https:\/\/www.has\u2010sante.fr\/jcms\/p_3636735\/fr\/transidentite\u2010prise\u2010en\u2010charge\u2010de\u2010l\u2010adulte."},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2019.02.001"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.70115"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2018.1482354"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.70905\/bmcj.05.02.0422"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2025.126335"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2019.07.004"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010319\u201069535\u20108_10"},{"key":"e_1_2_12_110_1","first-page":"23","article-title":"Effects of Ciprofloxacin and Levofloxacin on Semen Parameters of Male Rats","volume":"2","author":"Onemu S.","year":"2024","journal-title":"Elite Journal of Laboratory Medicine"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327116655390"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2024\/70943.19681"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.31024\/ajpp.2019.5.1.1"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.36103\/ijas.v52i6.1477"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11686\u2010025\u201001133\u20109"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.12834\/VetIt.2692.19722.2"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12891"},{"issue":"6","key":"e_1_2_12_118_1","first-page":"2471","article-title":"The Effect of Ivermectin on Secondary Spermatocytes and Serum Total Proteins","volume":"31","author":"Sweify K. M.","year":"2018","journal-title":"Pakistan Journal of Pharmaceutical Sciences"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2016.02.014"},{"issue":"2","key":"e_1_2_12_120_1","first-page":"328","article-title":"Miltefosine Induced Reduced Male Fertility Capacity After Treatment of Post Kala\u2010Azar Dermal Leishmaniasis, Bangladesh","volume":"28","author":"Basher A.","year":"2019","journal-title":"Mymensingh Medical Journal"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13558"},{"key":"e_1_2_12_122_1","unstructured":"\u201cHome\u2014Electronic Medicines Compendium (EMC) \u201d Accessed April 27 2026 https:\/\/www.medicines.org.uk\/emc."},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9703907"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew321"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2024.105848"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2022.09.008"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1177\/1557988318794282"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12350"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.5653\/cerm.2023.06772"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2023.2207038"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.21608\/ha.2020.37010.1066"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsi.2016.10.005"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12446"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13408"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.14436"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.09.010"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_35_17"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13260"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12855"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264\u2010016\u20100488\u20108"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43045\u2010023\u201000388\u20100"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12852"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.14207"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab190"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja202459"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12532"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2025.108933"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.603262"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.620936"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213698"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13311"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360\u2010024\u201000791\u20101"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2025.108981"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD22287"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327119871094"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2016.06.001"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6624101"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2019.04.001"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ard.2025.02.005"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.70010"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.54393\/mjz.v5i02.104"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.9734\/jpri\/2020\/v32i1430606"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP\u201017\u20100664"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.36283\/PJMD9\u20103\/004"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13778"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201077661\u20107"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c02587"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.22270\/jddt.v8i5.1891"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2024.108717"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v19i12.19"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12995"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.22037\/uj.v0i0.3954"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2017.02.032"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.4111\/icu.20200394"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.01.060"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006270"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.70021"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.985525"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.279253"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0304241"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaf106"},{"key":"e_1_2_12_182_1","unstructured":"VIDAL \u201c\u00c9clairer Vos D\u00e9cisions M\u00e9dicales \u201d VIDAL Accessed April 24 2026 https:\/\/www.vidal.fr\/."},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.765251"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0000000000003218"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00580\u2010019\u201002993\u20100"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja202365"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404\u2010020\u201005938\u2010z"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010025\u201003171\u20101"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010024\u201004171\u2010y"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12957"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP\u201015\u20100565"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29388"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2024.117119"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11102674"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958\u2010021\u201000794\u20101"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2019.01.003"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12020672"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105284"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16042"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.70022"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201064684\u20103"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2024.108629"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa022"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP\u201017\u20100390"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60010050"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.7326\/M21\u20104389"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102024\u2010080127"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpbs.jpbs_316_25"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebr.2021.100446"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.03.060"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.12.004"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.5935\/1518\u20100557.20240109"},{"key":"e_1_2_12_213_1","first-page":"128","article-title":"Impact de la Prise de Psychotropes sur la Fertilit\u00e9 Masculine","volume":"35","author":"Oukhaba S.","year":"2024","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2014.951324"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs\u20102013\u2010001862"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11092318"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anuro.2007.02.004"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015\u20100282(97)00363\u20104"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010\u20107824(80)90005\u20100"},{"key":"e_1_2_12_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010\u20107824(02)00277\u20109"},{"key":"e_1_2_12_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472\u20106483(10)60887\u20105"},{"key":"e_1_2_12_222_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107827\u20107\u2010114"},{"key":"e_1_2_12_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xfss.2025.02.004"},{"key":"e_1_2_12_224_1","volume-title":"Glutathione System and Oxidative Stress in Health and Disease","author":"Izquierdo A. C.","year":"2020"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70381","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.70381","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:15:47Z","timestamp":1789204547000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.70381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,12]]},"references-count":223,"alternative-id":["10.1111\/andr.70381"],"URL":"https:\/\/doi.org\/10.1111\/andr.70381","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,12]]},"assertion":[{"value":"2026-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"andr.70381"}}