{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:03:46Z","timestamp":1790345026601,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Adult\u2010onset testosterone deficiency, a condition characterised by low serum testosterone and hypogonadal symptoms is associated with a higher incidence of cardiovascular disease (CVD) and mortality.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate associations between change (\u0394) in total cholesterol (TC), triglycerides (TG) and low\u2010density lipoprotein (LDL)\u2010cholesterol and testosterone undecanoate (TU) treatment.<\/jats:p>\n <\/jats:sec>\n \n Materials & Methods<\/jats:title>\n \n We analysed a registry of men with adult\u2010onset TD (409 TU\u2010treated and 415 TU\u2010untreated men, median follow\u2010up 153 months), restricting the analysis to men whose statin treatment was not changed during follow\u2010up, thus avoiding statin related effects. The study cohort comprised the following groups: TU\u2010untreated\/not on statins (\n n<\/jats:italic>\n = 95), TU\u2010untreated\/on statins (\n n<\/jats:italic>\n = 245), TU\u2010treated\/not on statins (\n n<\/jats:italic>\n = 194), and TU\u2010treated\/on statins (\n n<\/jats:italic>\n = 207). Intra\u2010group non\u2010parametric statistics were performed as baseline characteristics varied between the study groups. We used multivariate and logistic regression models to determine predictors of \u2206 lipids (LDL\u2010cholesterol and TG) and mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Whilst there was a significant decrease in LDL\u2010cholesterol and TG (mostly in the initial 24 months) in the TU\u2010treated men, the reverse was evident in the untreated men, irrespective of concurrent statin therapy. Baseline LDL\u2010cholesterol and TG inversely predicted \u2206 values in the TU\u2010treated men, regardless of statin therapy. LDL\u2010cholesterol at final assessment appeared independently associated with mortality.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In this long\u2010term, real\u2010world registry, TC, TG, and LDL\u2010cholesterol decreased in the TU\u2010treated men with baseline values predicting the change, whilst a gradual increase was observed in the TU\u2010untreated men. Using published data, the relative risk reduction in CVD due to LDL\u2010cholesterol reduction is estimated to be around 40%.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/andr.70393","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:43:03Z","timestamp":1790343783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Testosterone Undecanoate Significantly Reduces Low Density Lipoprotein Cholesterol and Triglycerides in Men With Adult\u2010Onset Testosterone Deficiency"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5353-8118","authenticated-orcid":false,"given":"Anirudh","family":"Bhat","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry University Hospitals Birmingham NHS Foundation Trust West Midlands UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8170-9053","authenticated-orcid":false,"given":"Arjun Ajith","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry University Hospitals Birmingham NHS Foundation Trust West Midlands UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-7160","authenticated-orcid":false,"given":"Michael","family":"Zitzmann","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Andrology Centre of Reproductive Medicine and Andrology M\u00fcnster University Hospital M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0449-6635","authenticated-orcid":false,"given":"Farid","family":"Saad","sequence":"additional","affiliation":[{"name":"Research Department Gulf Medical University Ajman UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9289-3154","authenticated-orcid":false,"given":"Carola S.","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering Brunel University London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4396-9324","authenticated-orcid":false,"given":"Karim Sultan","family":"Haider","sequence":"additional","affiliation":[{"name":"Urological Practice Dr Haider Bremerhaven Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9252-0588","authenticated-orcid":false,"given":"Ahmad","family":"Haider","sequence":"additional","affiliation":[{"name":"Urological Practice Dr Haider Bremerhaven Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2073-3001","authenticated-orcid":false,"given":"Geoffrey","family":"Hackett","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences Aston University Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8042-9741","authenticated-orcid":false,"given":"Pieter","family":"Desnerck","sequence":"additional","affiliation":[{"name":"Department of Engineering University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5267-2018","authenticated-orcid":false,"given":"John","family":"Marriott","sequence":"additional","affiliation":[{"name":"School of Health Sciences College of Medicine and Health University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7972-4794","authenticated-orcid":false,"given":"Amar","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry University Hospitals Birmingham NHS Foundation Trust West Midlands UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0980-6348","authenticated-orcid":false,"given":"Richard C.","family":"Strange","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Bioengineering Keele University Staffordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2299-4133","authenticated-orcid":false,"given":"Sudarshan","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry University Hospitals Birmingham NHS Foundation Trust West Midlands UK"},{"name":"Department of Mechanical and Aerospace Engineering Brunel University London London UK"},{"name":"School of Pharmacy and Bioengineering Keele University Staffordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Cardiovascular diseases (CVDs) World Health Organisation 11th June 2021 (Cardiovascular diseases (whoint)\/health\u2010topics\/cardiovascular\u2010disease#tab = tab_1) accessed March 4 2026."},{"key":"e_1_2_10_3_1","first-page":"48","article-title":"The Lipid Hypothesis: From Resins to Proprotein Convertase Subtilisin\/Kexin Type\u20109 Inhibitors","volume":"5","author":"Ramachandran S.","year":"2020","journal-title":"Frontiers in Cardiovascular Drug Discovery"},{"issue":"15","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1056\/NEJMoa2215024","article-title":"Bempedoic Acid and Cardiovascular Outcomes in Statin\u2010Intolerant Patients","volume":"388","author":"Nissen S. E.","year":"2023","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/S0140-6736(10)61350-5","article-title":"Cholesterol Treatment Trialists' (CTT) Collaboration. Efficacy and Safety of More Intensive Lowering of LDL Cholesterol: A Meta\u2010Analysis of Data From 170,000 Participants in 26 Randomised Trials","volume":"376","author":"Baigent C.","year":"2010","journal-title":"Lancet"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.3390\/biomedicines11123208","article-title":"Age and the Residual Risk of Cardiovascular Disease Following Low Density Lipoprotein\u2013Cholesterol Exposure","volume":"11","author":"Konig C. S.","year":"2023","journal-title":"Biomedicines"},{"issue":"24","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1016\/j.jacc.2021.04.059","article-title":"Triglycerides and Residual Atherosclerotic Risk","volume":"77","author":"Raposeiras\u2010Roubin S.","year":"2021","journal-title":"Journal of the American College of Cardiology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/S0140-6736(10)60656-3","article-title":"Effects of Fibrates on Cardiovascular Outcomes: A Systematic Review and Meta\u2010Analysis","volume":"375","author":"Jun M.","year":"2010","journal-title":"Lancet"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2024.1389106","article-title":"Beyond LDL\u2010C: Unravelling the Residual Atherosclerotic Cardiovascular Disease Risk Landscape\u2010Focus on Hypertriglyceridaemia","volume":"11","author":"Bashir B.","year":"2024","journal-title":"Frontiers in Cardiovascular Medicine"},{"issue":"1","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12933-022-01525-5","article-title":"Elevated Plasma Triglyceride Concentration and Risk of Adverse Clinical Outcomes in 1.5 Million People: A CALIBER Linked Electronic Health Record Study","volume":"21","author":"Patel R. S.","year":"2022","journal-title":"Cardiovascular Diabetology"},{"issue":"3","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/MOL.0000000000000875","article-title":"Triglyceride\u2010Rich Lipoproteins, Remnant\u2010Cholesterol, and Atherosclerotic Cardiovascular Disease","volume":"34","author":"Ganda O. P.","year":"2023","journal-title":"Current Opinion in Lipidology"},{"issue":"4","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jacc.2012.08.1026","article-title":"Remnant Cholesterol as a Causal Risk Factor for Ischemic Heart Disease","volume":"61","author":"Varbo A.","year":"2013","journal-title":"Journal of the American College of Cardiology"},{"issue":"25","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1056\/NEJMoa1409065","article-title":"HDL Cholesterol Efflux Capacity and Incident Cardiovascular Events","volume":"371","author":"Rohatgi A.","year":"2014","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","DOI":"10.5534\/wjmh.221027","article-title":"The British Society for Sexual Medicine Guidelines on Male Adult Testosterone Deficiency, With Statements for Practice","volume":"41","author":"Hackett G.","year":"2023","journal-title":"World Journal of Men's Health"},{"issue":"2","key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.14797\/mdcj-13-2-68","article-title":"Testosterone and the Heart","volume":"13","author":"Goodale T.","year":"2017","journal-title":"Methodist Debakey Cardiovascular Journal"},{"issue":"2","key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa2215025","article-title":"Cardiovascular Safety of Testosterone\u2010Replacement Therapy","volume":"389","author":"Lincoff A. M.","year":"2023","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.31579\/2834-796X\/073","article-title":"The Inverse Association Between Testosterone Replacement Therapy and Cardiovascular Disease Risk: A Systematic 25\u2010Year Review and Meta\u2010Analysis Analysis of Prospective Cohort Studies From 1999 to 2024","volume":"3","author":"Borges J. Y. V.","year":"2024","journal-title":"International Journal of Cardiovascular Medicine"},{"issue":"2","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.mayocp.2014.10.011","article-title":"Testosterone Therapy and Cardiovascular Risk: Advances and Controversies","volume":"90","author":"Morgentaler A.","year":"2015","journal-title":"Mayo Clinic Proceedings"},{"issue":"7","key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1001\/jamacardio.2022.0912","article-title":"Association Between High\u2010Density Lipoprotein Cholesterol Levels and Adverse Cardiovascular Outcomes in High\u2010Risk Populations","volume":"7","author":"Liu C.","year":"2022","journal-title":"JAMA Cardiology"},{"key":"e_1_2_10_20_1","first-page":"1","article-title":"Design and Conduct of a Real\u2010World Single Center Registry Study on Testosterone Therapy in Men With Hypogonadism","volume":"2","author":"Haider K. S.","year":"2021","journal-title":"Androgens: Clinical Research and Therapeutics"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2340\/sju.v61.45576","article-title":"Long\u2010Term Effects of Testosterone Therapy on Prostate Volume and LUTS in Hypogonadal Men: A Retrospective Study","volume":"61","author":"Str\u00f6berg P.","year":"2026","journal-title":"Scandinavian Journal of Urology"},{"issue":"1","key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.5213\/inj.2040234.117","article-title":"Correlation Between Testosterone Replacement Treatment and Lower Urinary Tract Symptoms","volume":"25","author":"Lee M. H.","year":"2021","journal-title":"International Neurourology Journal"},{"issue":"6","key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the Concentration of Low\u2010Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge","volume":"18","author":"Friedewald W. T.","year":"1972","journal-title":"Clinical Chemistry"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jclinepi.2017.12.006","article-title":"Linear Regression and the Normality Assumption","volume":"98","author":"Schmidt A. F.","year":"2018","journal-title":"Journal of Clinical Epidemiology"},{"issue":"1","key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0021-9150(95)05673-4","article-title":"Effect of Testosterone Replacement Therapy on Lipids and Lipoproteins in Hypogonadal and Elderly Men","volume":"121","author":"Zgliczynski S.","year":"1996","journal-title":"Atherosclerosis"},{"issue":"6","key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/andr.13393","article-title":"Non\u2010Linear Association Between Testosterone and LDL Concentrations in Men","volume":"11","author":"Lee J. H.","year":"2023","journal-title":"Andrology"},{"issue":"1","key":"e_1_2_10_27_1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1210\/jc.2006-1375","article-title":"A Population\u2010Level Decline in Serum Testosterone Levels in American Men","volume":"92","author":"Travison T. G.","year":"2007","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"1","key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12958-020-00575-2","article-title":"Secular Trends in Testosterone\u2014Findings From a Large State\u2010Mandate Care Provider","volume":"18","author":"Chodick G.","year":"2020","journal-title":"Reproductive Biology and Endocrinology"},{"issue":"6","key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1111\/andr.13582","article-title":"Testosterone Replacement Therapy: Association With Mortality in High\u2010risk Patient Subgroups","volume":"12","author":"Mann A.","year":"2024","journal-title":"Andrology"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/ijcp.12779","article-title":"Serum Testosterone, Testosterone Replacement Therapy and All\u2010Cause Mortality in Men With Type 2 Diabetes: Retrospective Consideration of the Impact of PDE5 Inhibitors and Statins","volume":"70","author":"Hackett G.","year":"2016","journal-title":"International Journal of Clinical Practice"},{"issue":"6","key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1530\/EJE-13-0321","article-title":"Testosterone Deficiency is Associated With Increased Risk of Mortality and Testosterone Replacement Improves Survival in Men With Type 2 Diabetes","volume":"169","author":"Muraleedharan V.","year":"2013","journal-title":"European Journal of Endocrinology"},{"issue":"6","key":"e_1_2_10_32_1","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1210\/jc.2011-2591","article-title":"Testosterone Treatment and Mortality in Men With Low Testosterone","volume":"97","author":"Shores M. M.","year":"2012","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"4","key":"e_1_2_10_33_1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.5534\/wjmh.230239","article-title":"Testosterone Replacement Therapy: Effects on Blood Pressure in Hypogonadal Men","volume":"42","author":"Hackett G.","year":"2024","journal-title":"World Journal of Men's Health"},{"issue":"6","key":"e_1_2_10_34_1","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1111\/dom.15520","article-title":"Testosterone Therapy Reduces Insulin Resistance in Men With Adult\u2010Onset Testosterone Deficiency and Metabolic Syndrome. Results From the Moscow Study, a Randomized Controlled Trial With an Open\u2010Label Phase","volume":"26","author":"Tishova Y.","year":"2024","journal-title":"Diabetes, Obesity & Metabolism"},{"key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/bju.14536","article-title":"Long\u2010Term Testosterone Therapy in Type 2 Diabetes is Associated With Reduced Mortality Without Improvement in Conventional Cardiovascular Risk Factors","volume":"123","author":"Hackett G. I.","year":"2019","journal-title":"BJU"},{"key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1093\/eurheartj\/ehu467","article-title":"Wilder's Principle: Pre\u2010Treatment Value Determines Post\u2010Treatment Response","volume":"36","author":"Messerli F. H.","year":"2015","journal-title":"European Heart Journal"},{"issue":"10","key":"e_1_2_10_37_1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3390\/metabo11100690","article-title":"Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target","volume":"11","author":"Behbodikhah J.","year":"2021","journal-title":"Metabolites"},{"issue":"27","key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1093\/eurheartj\/ehaf207","article-title":"ApoB\u2010Containing Lipoproteins: Count, Type, Size, and Risk of Coronary Artery Disease","volume":"46","author":"Morze J.","year":"2025","journal-title":"European Heart Journal"},{"issue":"8","key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.tem.2013.04.001","article-title":"The Regulation of ApoB Metabolism by Insulin","volume":"24","author":"Haas M. E.","year":"2013","journal-title":"Trends in Endocrinology and Metabolism"},{"issue":"1","key":"e_1_2_10_40_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-27182-y","article-title":"Testosterone Is Associated With Abdominal Body Composition Derived From Computed Tomography: A Large Cross\u2010Sectional Study","volume":"12","author":"Han S.","year":"2022","journal-title":"Scientific Reports"},{"issue":"2","key":"e_1_2_10_41_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jacl.2014.11.005","article-title":"Discordance Between Apolipoprotein B and Low\u2010Density Lipoprotein Particle Number is Associated With Insulin Resistance in Clinical Practice","volume":"9","author":"Varvel S. A.","year":"2015","journal-title":"Journal of Clinical Lipidology"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70393","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.70393","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:43:12Z","timestamp":1790343792000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.70393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":40,"alternative-id":["10.1111\/andr.70393"],"URL":"https:\/\/doi.org\/10.1111\/andr.70393","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"assertion":[{"value":"2026-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"andr.70393"}}