{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:52:24Z","timestamp":1791175944841,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypogonadism is frequently observed in men living with\u00a0 human immunodeficiency virus (HIV), although its prevalence, etiology, and predictors remain incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the prevalence of hypogonadism and its association with metabolic factors in men living with HIV (MLWH), on stable antiretroviral therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Total testosterone (TT), sex hormone\u2010binding globulin (SHBG), calculated free testosterone (cFT), metabolic parameters, and ADAM questionnaire responses\u00a0were assessed in\u00a0136 MLWH (19\u201373 years), classified as hypogonadal or eugonadal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Subnormal cFT or TT levels were detected in 35.3% of the participants; 52.1% had isolated low cFT and 78.4% were hypogonadotropic. ADAM showed 75.6% sensitivity and 44.7% specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Hypertension, dysglycemia, higher triglycerides levels, higher BMI, increased waist circumference, older age, longer time of infection, and insulin resistance indexes were positively associated with hypogonadism in univariate analysis. Serum estradiol levels were similar between groups. After multivariate analysis, age and dysglycemia remained independently associated with testosterone deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>One\u2010third of MLWH had hypogonadism, mostly of central origin.\u00a0cFT assessment was essential to avoid underdiagnosis. Hypogonadism in MLWH seems to be associated with metabolic impairment, however only age and dysglycemia remained independently associated after adjustment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70400","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:25:00Z","timestamp":1791174300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypogonadism in Cisgender Men Living With HIV: Prevalence, Clinical and Metabolic Features"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1105-0655","authenticated-orcid":false,"given":"Felipe Augusto Azevedo","family":"Leao","sequence":"first","affiliation":[{"name":"Servico de Endocrinologia Departamento De Clinica Medica Da Faculdade de Medicina da Universidade Federal De Minas Gerais  Belo Horizonte Brazil"},{"name":"Servico de Endocrinologia Instituto Orizonti  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Cabreira","family":"Nunes","sequence":"additional","affiliation":[{"name":"Servico de Endocrinologia Departamento De Clinica Medica Da Faculdade de Medicina da Universidade Federal De Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela Almeida","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Servico de Endocrinologia Departamento De Clinica Medica Da Faculdade de Medicina da Universidade Federal De Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza Costa da","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Servico de Endocrinologia Departamento De Clinica Medica Da Faculdade de Medicina da Universidade Federal De Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2979-0614","authenticated-orcid":false,"given":"Aline Cristina Miranda Marinho","family":"Costa","sequence":"additional","affiliation":[{"name":"Servico de Endocrinologia Departamento De Clinica Medica Da Faculdade de Medicina da Universidade Federal De Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2295-0229","authenticated-orcid":false,"given":"Mateus Rodrigues","family":"Westin","sequence":"additional","affiliation":[{"name":"Servico de Doencas Infecciosas e Parasitarias Departamento De Clinica Medica Da Faculdade de Medicina da Universidade Federal De Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3681-4124","authenticated-orcid":false,"given":"Unai","family":"Tupinambas","sequence":"additional","affiliation":[{"name":"Servico de Doencas Infecciosas e Parasitarias Departamento De Clinica Medica Da Faculdade de Medicina da Universidade Federal De Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3651-185X","authenticated-orcid":false,"given":"Milena Maria Moreira","family":"Guimaraes","sequence":"additional","affiliation":[{"name":"Servico de Endocrinologia Departamento De Clinica Medica Da Faculdade de Medicina da Universidade Federal De Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0053-9167","authenticated-orcid":false,"given":"Leticia Ferreira Gontijo","family":"Silveira","sequence":"additional","affiliation":[{"name":"Servico de Endocrinologia Departamento De Clinica Medica Da Faculdade de Medicina da Universidade Federal De Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"issue":"5","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1210\/jc.2018-00229","article-title":"Testosterone Therapy in Men with Hypogonadism: An Endocrine Society Clinical Practice Guideline","volume":"103","author":"Bhasin S.","year":"2018","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"5","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1210\/jc.2012-3550","article-title":"Approach to the Patient With Hypogonadotropic Hypogonadism","volume":"98","author":"Silveira L. F.","year":"2013","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"3","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.ecl.2014.06.005","article-title":"Hypogonadism in the HIV\u2010Infected Man","volume":"43","author":"Rochira V.","year":"2014","journal-title":"Endocrinology and Metabolism Clinics of North America"},{"issue":"11","key":"e_1_2_10_5_1","first-page":"4051","article-title":"Loss of Lean Body and Muscle Mass Correlates With Androgen Levels in Hypogonadal Men With Acquired Immunodeficiency Syndrome and Wasting","volume":"81","author":"Grinspoon S.","year":"1996","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"7","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/0026-0495(95)90250-3","article-title":"Testicular Dysfunction in Human Immunodeficiency Virus\u2010Infected Men","volume":"44","author":"Poretsky L.","year":"1995","journal-title":"Metabolism"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"25","article-title":"Opportunistic Infections of the Testis in the Acquired Immunodeficiency Syndrome","volume":"57","author":"De Paepe M. E.","year":"1990","journal-title":"Mount Sinai Journal of Medicine"},{"issue":"8","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s40618-017-0812-x","article-title":"Endocrinological Aspects of HIV Infection","volume":"41","author":"Mirza F. S.","year":"2018","journal-title":"Journal of Endocrinological Investigation"},{"issue":"2","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s15010-020-01558-6","article-title":"The Importance of SHBG and Calculated Free Testosterone for the Diagnosis of Symptomatic Hypogonadism in HIV\u2010Infected Men: a Single\u2010Centre Real\u2010Life Experience","volume":"49","author":"Pezzaioli L. C.","year":"2021","journal-title":"Infection"},{"issue":"1","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/13685538.2022.2039116","article-title":"Primary, Secondary and Compensated Male Biochemical Hypogonadism in People Living With HIV (PLWH): Relevance of Sex Hormone\u2010Binding Globulin (SHBG) Measurement and Comparison Between Liquid Chromatography\u2013Tandem Mass Spectrometry (LC\u2013MS\/MS) and Chemiluminescent Immunoassay for Sex Steroids Assay","volume":"25","author":"De Vincentis S.","year":"2022","journal-title":"Aging Male"},{"issue":"8","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","DOI":"10.3390\/cells10082067","article-title":"The Prevalence of Hypogonadism and the Effectiveness of Androgen Administration on Body Composition in HIV\u2010Infected Men: A Meta\u2010Analysis","volume":"10","author":"Santi D.","year":"2021","journal-title":"Cells"},{"issue":"8","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1097\/QAD.0000000000003176","article-title":"Hypogonadism: A Neglected Comorbidity in Young and Middle\u2010Aged HIV\u2010Positive Men on Effective Combination Antiretroviral Therapy","volume":"36","author":"Lach\u00e2tre M.","year":"2022","journal-title":"Aids"},{"issue":"1","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1186\/s12879-016-1892-5","article-title":"Prevalence of Testosterone Deficiency in HIV\u2010Infected Men Under Antiretroviral Therapy","volume":"16","author":"Gomes A. R.","year":"2016","journal-title":"BMC Infectious Diseases"},{"issue":"1","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ijir.2009.35","article-title":"The Quantitative ADAM Questionnaire: A New Tool in Quantifying the Severity of Hypogonadism","volume":"22","author":"Mohamed O.","year":"2010","journal-title":"International Journal of Impotence Research"},{"issue":"9","key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1053\/meta.2000.8625","article-title":"Validation of a Screening Questionnaire for Androgen Deficiency in Aging Males","volume":"49","author":"Morley J. E.","year":"2000","journal-title":"Metabolism"},{"issue":"10","key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","article-title":"A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum","volume":"84","author":"Vermeulen A.","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"1","key":"e_1_2_10_17_1","first-page":"S27","article-title":"Committee ADAPP. 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes\u20102025","volume":"48","year":"2025","journal-title":"Diabetes Care"},{"issue":"4","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3121\/cmr.2020.1509","article-title":"Lipid Accumulation Product Index to Predict Metabolic Syndrome in People Living With HIV","volume":"18","author":"Raposo M. A.","year":"2020","journal-title":"Clinical Medicine & Research"},{"issue":"3","key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s40618-022-01941-0","article-title":"Cardiometabolic Indices Predict Hypogonadism in Male Patients with Type 2 Diabetes","volume":"46","author":"Caretta N.","year":"2023","journal-title":"Journal of Endocrinological Investigation"},{"issue":"7","key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1210\/jc.2010-0288","article-title":"The Product of Triglycerides and Glucose, A Simple Measure of Insulin Sensitivity. Comparison with the Euglycemic\u2010Hyperinsulinemic Clamp","volume":"95","author":"Guerrero\u2010Romero F.","year":"2010","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"8","key":"e_1_2_10_21_1","doi-asserted-by":"crossref","DOI":"10.1590\/0102-311x00072120","article-title":"Homeostasis Model Assessment of Insulin Resistance (HOMA\u2010IR) and Metabolic Syndrome at Baseline of a Multicentric Brazilian Cohort: ELSA\u2010Brasil Study","volume":"36","author":"Diniz M.","year":"2020","journal-title":"Cadernos De Saude Publica"},{"issue":"11","key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1515\/cclm-2021-0643","article-title":"Distribution of HOMA\u2010IR in a Population\u2010Based Cohort and Proposal for Reference Intervals","volume":"59","author":"Matli B.","year":"2021","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"issue":"2","key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/andr.310","article-title":"Low Testosterone is Associated With Poor Health Status in Men With human Immunodeficiency Virus Infection: A Retrospective Study","volume":"3","author":"Rochira V.","year":"2015","journal-title":"Andrology"},{"issue":"12","key":"e_1_2_10_24_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028512","article-title":"Premature Decline of Serum Total Testosterone in HIV\u2010Infected Men in the HAART\u2010Era","volume":"6","author":"Rochira V.","year":"2011","journal-title":"PLoS ONE"},{"issue":"5","key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.jmii.2024.05.006","article-title":"Hypogonadism Among HIV\u2010Positive Men Who Have Sex with Men in Taiwan: Prevalence and Associated Factors","volume":"57","author":"Lin K. Y.","year":"2024","journal-title":"Journal of Microbiology, Immunology and Infection"},{"issue":"5","key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2174\/1570162X18666200720000344","article-title":"Prevalence of and Risk Factors for Low Free Testosterone Levels in Japanese Men With Well\u2010controlled Human Immunodeficiency Virus Infection","volume":"18","author":"Yoshino Y.","year":"2020","journal-title":"Current HIV Research"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/9679935","article-title":"Prevalence of Hypogonadism and Associated Risk Factors Among Newly Diagnosed ART Na\u00efve HIV\u2010Infected Males in Mwanza, Tanzania","volume":"2024","author":"Iddi S.","year":"2024","journal-title":"International Journal of Endocrinology"},{"issue":"6","key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.2164\/jandrol.112.016758","article-title":"Highly Active Antiretroviral Therapy (HAART) and Testicular Morphology: Current Status and a Case for a Stereologic Approach","volume":"33","author":"Azu O. O.","year":"2012","journal-title":"Journal of Andrology"},{"issue":"8","key":"e_1_2_10_29_1","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvae129","article-title":"SHBG, Free Testosterone, and Type 2 Diabetes Risk in Middle\u2010Aged African Men: A Longitudinal Study","volume":"8","author":"Seipone I. D.","year":"2024","journal-title":"Journal of the Endocrine Society"},{"issue":"1","key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41572-019-0087-y","article-title":"Paediatric and Adult\u2010Onset Male Hypogonadism","volume":"5","author":"Salonia A.","year":"2019","journal-title":"Nature Reviews Disease Primers"},{"issue":"5","key":"e_1_2_10_31_1","first-page":"970","article-title":"European Academy of Andrology (EAA) Guidelines on Investigation, Treatment and Monitoring of Functional Hypogonadism in Males: Endorsing Organization","volume":"8","author":"Corona G.","year":"2020","journal-title":"European Society of Endocrinology Andrology"},{"issue":"3","key":"e_1_2_10_32_1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1210\/jc.2016-3580","article-title":"A Perspective on Middle\u2010Aged and Older Men with Functional Hypogonadism: Focus on Holistic Management","volume":"102","author":"Grossmann M.","year":"2017","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"4","key":"e_1_2_10_33_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2022.101622","article-title":"Ageing Male (Part I): Pathophysiology and Diagnosis of Functional Hypogonadism","volume":"36","author":"Huhtaniemi I. T.","year":"2022","journal-title":"Best Practice & Research Clinical Endocrinology & Metabolism"},{"issue":"2","key":"e_1_2_10_34_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1056\/NEJMoa0911101","article-title":"Identification of Late\u2010Onset Hypogonadism in Middle\u2010Aged and Elderly Men","volume":"363","author":"Wu F. C.","year":"2010","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1530\/EJE-19-0666","article-title":"Prevalence of Endocrine Disorders in Obese Patients: Systematic Review and Meta\u2010Analysis","volume":"182","author":"Hulsteijn L. T.","year":"2020","journal-title":"European Journal of Endocrinology"},{"issue":"7","key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.2337\/dc17-2510","article-title":"Hypogonadotropic Hypogonadism in Men With Diabesity","volume":"41","author":"Dhindsa S.","year":"2018","journal-title":"Diabetes Care"},{"key":"e_1_2_10_37_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12933-014-0146-3","article-title":"Clinical Usefulness of Lipid Ratios, Visceral Adiposity Indicators, and the Triglycerides and Glucose Index as Risk Markers of Insulin Resistance","volume":"13","author":"Du T.","year":"2014","journal-title":"Cardiovascular Diabetology"},{"issue":"3","key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.numecd.2021.11.017","article-title":"Comparison of Triglyceride\u2010Glucose Index and HOMA\u2010IR for Predicting Prevalence and Incidence of Metabolic Syndrome","volume":"32","author":"Son D. H.","year":"2022","journal-title":"Nutrition, Metabolism and Cardiovascular Diseases"},{"issue":"6","key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s11154-022-09746-5","article-title":"Obesity, Type 2 Diabetes, and Testosterone in Ageing Men","volume":"23","author":"Wittert G.","year":"2022","journal-title":"Reviews in Endocrine & Metabolic Disorders"},{"key":"e_1_2_10_40_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3389\/fendo.2019.00345","article-title":"Metabolic Disorders and Male Hypogonadotropic Hypogonadism","volume":"10","author":"Pivonello R.","year":"2019","journal-title":"Frontiers in Endocrinology"},{"issue":"7","key":"e_1_2_10_41_1","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1111\/j.1743-6109.2011.02292.x","article-title":"Body Mass Index Regulates Hypogonadism\u2010Associated CV Risk: Results From a Cohort of Subjects With Erectile Dysfunction","volume":"8","author":"Corona G.","year":"2011","journal-title":"Journal of Sexual Medicine"},{"issue":"1","key":"e_1_2_10_42_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1186\/s12889-025-21744-1","article-title":"The Triglyceride\u2010glucose Index Trajectories are Associated With Cardiovascular Diseases in People Living With HIV: Evidence From a Prospective Cohort Study in China, 2005\u20132022","volume":"25","author":"Luo Y.","year":"2025","journal-title":"BMC Public Health"},{"key":"e_1_2_10_43_1","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.2147\/IDR.S493140","article-title":"Association Between TyG Index, Liver Steatosis and Immunosenescence in People Living With HIV","volume":"17","author":"Yan H.","year":"2024","journal-title":"Infection and Drug Resistance"},{"issue":"6","key":"e_1_2_10_44_1","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofaf324","article-title":"Evaluation of Insulin Resistance Markers for Diagnosing Moderate to Severe Hepatic Steatosis in Patients With Human Immunodeficiency Virus Using Transient Elastography","volume":"12","author":"B\u00e1guena C.","year":"2025","journal-title":"Open Forum Infectious Diseases"},{"issue":"2","key":"e_1_2_10_45_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.15537\/smj.2025.46.2.20240769","article-title":"Concordance Between Homeostatic Model Assessment and Triglyceride Glucose Index in Assessing Insulin Resistance Among HIV\u2010Infected Patients","volume":"46","author":"Budak G. G.","year":"2025","journal-title":"Saudi Medical Journal"},{"issue":"3","key":"e_1_2_10_46_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bjid.2018.03.006","article-title":"Lipid Accumulation Product Index in HIV\u2010Infected Patients: A Marker of Cardiovascular Risk","volume":"22","author":"Guimar\u00e3es M. M. M.","year":"2018","journal-title":"Brazilian Journal of Infectious Diseases"},{"issue":"8","key":"e_1_2_10_47_1","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofad398","article-title":"Visceral Adiposity Index as a Measure of Cardiovascular Disease in Persons With Human Immunodeficiency Virus","volume":"10","author":"Thomas T. S.","year":"2023","journal-title":"Open Forum Infectious Diseases"},{"issue":"8","key":"e_1_2_10_48_1","article-title":"Inflammatory, Cardiac, and Lipid\u2010Related Biomarkers in Relation to Residual MACE Risk in the REPRIEVE Trial","volume":"5","author":"Grinspoon S. K.","year":"2026","journal-title":"JACC: Advances"},{"issue":"11","key":"e_1_2_10_49_1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1055\/a-1210-2482","article-title":"Functional Hypogonadism and Testosterone Deficiency in Aging Males With and Without HIV\u2010Infection","volume":"129","author":"Postel N.","year":"2021","journal-title":"Experimental and Clinical Endocrinology & Diabetes"},{"key":"e_1_2_10_50_1","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1007\/s40618-025-02683-5","article-title":"Gonadal and Sexual Function in Men Living With HIV: Insights From a Single\u2010Centre Study","volume":"48","author":"Bonaventura I.","year":"2025","journal-title":"Journal of Endocrinological Investigation"},{"issue":"11","key":"e_1_2_10_51_1","doi-asserted-by":"crossref","first-page":"e782","DOI":"10.1016\/S2352-3018(20)30236-8","article-title":"Hypogonadism and Bone Health in Men With HIV","volume":"7","author":"Maffezzoni F.","year":"2020","journal-title":"Lancet HIV"},{"key":"e_1_2_10_52_1","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1201696","article-title":"Update on Acquired Hypogonadism in Men Living With HIV: Pathogenesis, Clinic, and Treatment","volume":"14","author":"De Vincentis S.","year":"2023","journal-title":"Frontiers in Endocrinology"},{"issue":"6","key":"e_1_2_10_53_1","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1093\/ejendo\/lvae128","article-title":"Mechanisms in Endocrinology: Hypogonadism and Metabolic Health in Men\u2010Novel Insights Into Pathophysiology","volume":"191","author":"Miller C.","year":"2024","journal-title":"European Journal of Endocrinology"},{"issue":"2","key":"e_1_2_10_54_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1210\/endrev\/bnad028","article-title":"Adipose Tissue Dysfunction and Energy Balance Paradigms in People Living With HIV","volume":"45","author":"Ramirez Bustamante C. E.","year":"2024","journal-title":"Endocrine Reviews"},{"issue":"6","key":"e_1_2_10_55_1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.4103\/ijmr.IJMR_1926_15","article-title":"Occurrence, Patterns & Predictors of Hypogonadism in Patients With HIV Infection in India","volume":"145","author":"Dutta D.","year":"2017","journal-title":"Indian Journal of Medical Research"},{"issue":"7","key":"e_1_2_10_56_1","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1210\/jc.2007-1972","article-title":"Hypothalamic\u2013Pituitary\u2013Testicular Axis Disruptions in Older Men are Differentially Linked to Age and Modifiable Risk Factors: The European Male Aging Study","volume":"93","author":"Wu F. C.","year":"2008","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"5","key":"e_1_2_10_57_1","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1210\/jc.2011-2513","article-title":"Characteristics of Androgen Deficiency in Late\u2010Onset Hypogonadism: Results From the European Male Aging Study (EMAS)","volume":"97","author":"Tajar A.","year":"2012","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"4","key":"e_1_2_10_58_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3109\/13685538.2014.963041","article-title":"Comparison of Questionnaires Used for Screening and Symptom Identification in Hypogonadal Men","volume":"17","author":"Bernie A. M.","year":"2014","journal-title":"Aging Male"},{"issue":"5","key":"e_1_2_10_59_1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.2164\/jandrol.111.015628","article-title":"The Comparison of the Aging Male Symptoms (AMS) Scale and Androgen Deficiency in the Aging Male (ADAM) Questionnaire to Detect Androgen Deficiency in Middle\u2010Aged Men","volume":"33","author":"Chueh K. S.","year":"2012","journal-title":"Journal of Andrology"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70400","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.70400","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.70400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:25:07Z","timestamp":1791174307000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.70400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,4]]},"references-count":58,"alternative-id":["10.1111\/andr.70400"],"URL":"https:\/\/doi.org\/10.1111\/andr.70400","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,4]]},"assertion":[{"value":"2026-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"andr.70400"}}