{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:50:05Z","timestamp":1791528605097,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Klinefelter syndrome (KS), typically characterized by a 47, XXY karyotype, is the most common sex chromosomal aneuploidy in males, with a prevalence of approximately one in 600\u2013660 individuals. Despite its frequency, the syndrome remains significantly underdiagnosed, with 50%\u201375% of affected individuals never receiving a clinical diagnosis. While the classic phenotype includes hypergonadotropic hypogonadism and infertility, recent evidence highlights a lifelong burden of neurocognitive, psychological, and socioeconomic challenges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study synthesizes current evidence regarding the determinants of quality of life (QoL) in men with KS, specifically contextualizing the registry data and clinical trajectories discussed during the fourth International Workshop on Klinefelter Syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>To perform a narrative review, a literature search was conducted across major electronic databases, including PubMed\/MEDLINE, Scopus, and the Cochrane Library. The search focused on peer\u2010reviewed articles published up to March 2026, utilizing primary keywords such as \u201cKlinefelter Syndrome,\u201d \u201c47, XXY, \u201d \u201cQuality of Life, \u201d \u201cSocioeconomic Status, \u201d and \u201cTestosterone Replacement Therapy.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Affected individuals consistently report lower QoL across physical, psychological, and social domains compared to healthy controls, with social relationship scores often reaching levels observed in psychiatric reference populations. Key drivers of reduced well\u2010being include lower educational achievement, precarious employment, chronic health comorbidities, and experienced discrimination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>While testosterone replacement therapy is essential for physical virilization, it is frequently insufficient to normalize QoL or alleviate deep\u2010seated psychological distress, highlighting the impact of unmitigated developmental hurdles, metabolic burdens, and infertility\u2010related psychological trauma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A multidisciplinary approach\u2014integrating endocrinology with specialized psychological, fertility, and educational support\u2014is strictly required to address the complex, multidimensional needs of this population across the lifespan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70409","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:02:16Z","timestamp":1791525736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multidimensional Determinants of Quality of Life in Men With Klinefelter Syndrome: A Narrative Review of Workshop Evidence"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2639-1520","authenticated-orcid":false,"given":"Francesca","family":"Allosso","sequence":"first","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania Luigi Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Digitale Selvaggio","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania Luigi Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5674-635X","authenticated-orcid":false,"given":"Daniela","family":"Pasquali","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania Luigi Vanvitelli  Naples 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