{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:54:52Z","timestamp":1791381292492,"version":"4.3.3"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007398","name":"Strategiske Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["2107\u201005\u20100006"],"award-info":[{"award-number":["2107\u201005\u20100006"]}],"id":[{"id":"10.13039\/100007398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001734","name":"K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["9700909"],"award-info":[{"award-number":["9700909"]}],"id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our objective was to develop age\u2010 and height\u2010specific reference ranges for blood pressure, pulse pressure and mean arterial pressure in healthy boys and to compare these to measurements in patients with Klinefelter syndrome followed longitudinally through childhood and adolescence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cohort study consisting of a population\u2010based reference cohort including 1842 healthy non\u2010obese boys aged 0\u201320 years and 67 patients with Klinefelter syndrome aged 7\u201320 years, followed at a single tertiary center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Height, weight, and blood pressure were measured, and references were developed as a function of age, height, and their combined effect in healthy boys. In patients with Klinefelter syndrome standard deviation scores were calculated for systolic and diastolic blood pressure, pulse pressure and mean arterial pressure. These were adjusted for age and height independently, as well as combined age and height. A subgroup analysis in patients with Klinefelter syndrome assessed whether testosterone replacement therapy influenced blood pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Systolic and diastolic blood pressure increased with increasing age in healthy boys. Patients with Klinefelter syndrome had significantly lower systolic blood pressure compared to the healthy, non\u2010obese reference population, with a mean standard deviation score of \u20130.65, \u20130.90, \u20130.91 when adjusted for age, height, and both, respectively. Diastolic blood pressure did not differ from controls. Pulse pressure showed a mean standard deviation score of \u20130.74, \u20130.99, and \u20130.94 when adjusting for age, height or both, respectively. Mean arterial pressure showed a mean standard deviation score of \u20130.27, \u20130.33, and \u20130.41 adjusted for age, height or both, respectively. Testosterone replacement therapy had no significant effect on blood pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study showed that patients with Klinefelter syndrome have lower systolic but similar diastolic blood pressure compared to our new blood pressure reference ranges. Pulse pressure and mean arterial pressure were both significantly lower after any adjustment compared to healthy controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70410","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:16:24Z","timestamp":1791378984000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lower Systolic Blood Pressure in 67 Boys With Klinefelter Syndrome Compared to 1842 Healthy Danish Boys"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9816-4091","authenticated-orcid":false,"given":"Andr\u00e9s Felipe \u00d8.","family":"Fritzb\u00f8ger","sequence":"first","affiliation":[{"name":"Department of Growth and Reproduction Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"International Centre for Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child 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