{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:44:33Z","timestamp":1791809073373,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD086742"],"award-info":[{"award-number":["R01HD086742"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD105863"],"award-info":[{"award-number":["R01HD105863"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD094322"],"award-info":[{"award-number":["R21HD094322"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Few studies have examined the association between caffeine intake and semen quality among couples attempting conception.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To examine the effect of caffeinated beverage intake on semen quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed cross\u2010sectional data from Pregnancy Study Online (PRESTO), a preconception cohort study. We invited US residents aged \u2265 21 years to perform at\u2010home semen testing (\n                      <jats:italic>n<\/jats:italic>\n                      = 929 participants; 1668 samples). The outcomes included semen volume, sperm concentration, total sperm count (TSC), percent motility, and total motile sperm count (TMSC). Participants reported their past\u2010month intakes of caffeinated coffee, tea, soda, and energy drinks, from which we calculated caffeine intake. We used multivariable linear regression to estimate mean percentage differences (%\n                      <jats:italic>D<\/jats:italic>\n                      ) and 95% confidence intervals (CIs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median caffeine intake was 138\u2009mg\/day (interquartile range = 51\u2013270\u2009mg\/day). No monotonic associations were observed for intakes of coffee, tea, soda, or energy drinks. Comparing caffeine intakes of \u2265 200\u2009versus &lt; 100\u2009mg\/day, we found no consistent associations with semen volume (%\n                      <jats:italic>D<\/jats:italic>\n                      [95% CI]: 0.2 [\u22128.2, 8.6]), sperm concentration (\u22129.1 [\u221223.2, 7.5]), TSC (\u221210.1 [\u221223.7, 6.0]), % motility (2.4 [\u22123.5, 8.3]), or TMSC (\u22127.9 [\u221223.5, 11.0]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Caffeinated beverage intake was not consistently associated with semen parameters in this preconception cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Moderate caffeine intake has little effect on semen quality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.70415","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:44:52Z","timestamp":1791805492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Caffeinated Beverage Intake and Semen Quality in a Preconception Cohort"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8912-8232","authenticated-orcid":false,"given":"Sachelly","family":"Juli\u00e1n\u2010Serrano","sequence":"first","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth J.","family":"Geller","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha 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