{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:06:52Z","timestamp":1762506412580},"reference-count":35,"publisher":"Hindawi Limited","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":355,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurol Scand"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1111\/ane.12273","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T06:18:30Z","timestamp":1410416310000},"page":"347-353","source":"Crossref","is-referenced-by-count":12,"title":["Relationship and factor structure in multisystem neurodegeneration in Parkinson's disease"],"prefix":"10.1155","volume":"130","author":[{"given":"T.","family":"Hattori","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurological Sciences; Graduate School; Tokyo Medical and Dental University; Tokyo Japan"},{"name":"Department of Neurology; Kanto Central Hospital; Tokyo Japan"},{"name":"Human Motor Control Section; National Institute of Neurological Disorders and Stroke; National Institutes of Health; Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Orimo","sequence":"additional","affiliation":[{"name":"Department of Neurology; Kanto Central Hospital; Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hallett","sequence":"additional","affiliation":[{"name":"Human Motor Control Section; National Institute of Neurological Disorders and Stroke; National Institutes of Health; Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Wu","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Program; National Institute of Neurological Disorders and Stroke; National Institutes of Health; Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Neurology; Kanto Central Hospital; Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Azuma","sequence":"additional","affiliation":[{"name":"Department of Neurology; Kanto Central Hospital; Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Mizusawa","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences; Graduate School; Tokyo Medical and Dental University; Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","published-online":{"date-parts":[[2014,9,11]]},"reference":[{"key":"10.1111\/ane.12273-BIB0001|ane12273-cit-0001","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/ana.20834","article-title":"The Parkinson's complex: parkinsonism is just the tip of the iceberg","volume":"59","author":"Langston","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1111\/ane.12273-BIB0002|ane12273-cit-0002","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/mds.23795","article-title":"Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts","volume":"27","author":"Jellinger","year":"2012","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12273-BIB0003|ane12273-cit-0003","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1212\/WNL.0b013e3181ca014c","article-title":"Association of anosmia with autonomic failure in Parkinson disease","volume":"74","author":"Goldstein","year":"2010","journal-title":"Neurology"},{"key":"10.1111\/ane.12273-BIB0004|ane12273-cit-0004","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/mds.23001","article-title":"Cardiac sympathetic degeneration correlates with olfactory function in Parkinson's disease","volume":"25","author":"Iijima","year":"2010","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12273-BIB0005|ane12273-cit-0005","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00415-009-5447-1","article-title":"Olfactory dysfunction and cardiovascular dysautonomia in Parkinson's disease","volume":"257","author":"Oka","year":"2010","journal-title":"J Neurol"},{"key":"10.1111\/ane.12273-BIB0006|ane12273-cit-0006","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/mds.23602","article-title":"Association of olfactory dysfunction and brain. Metabolism in Parkinson's disease","volume":"26","author":"Baba","year":"2011","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12273-BIB0007|ane12273-cit-0007","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jns.2008.02.017","article-title":"Cardiac sympathetic denervation is correlated with Parkinsonian midline motor symptoms","volume":"270","author":"Kim","year":"2008","journal-title":"J Neurol Sci"},{"key":"10.1111\/ane.12273-BIB0008|ane12273-cit-0008","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/mds.21499","article-title":"Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease","volume":"22","author":"Spiegel","year":"2007","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12273-BIB0009|ane12273-cit-0009","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/ane.12189","article-title":"Cognitive impairment in early-stage non-demented Parkinson's disease patients","volume":"129","author":"Pfeiffer","year":"2014","journal-title":"Acta Neurol Scand"},{"key":"10.1111\/ane.12273-BIB0010|ane12273-cit-0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/mds.25150","article-title":"Parkinson's disease: evidence for environmental risk factors","volume":"28","author":"Kieburtz","year":"2013","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12273-BIB0011|ane12273-cit-0011","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson's disease","volume":"5","author":"De Lau","year":"2006","journal-title":"Lancet Neurol"},{"key":"10.1111\/ane.12273-BIB0012|ane12273-cit-0012","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1111\/ane.12273-BIB0013|ane12273-cit-0013","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1002\/mds.23429","article-title":"Systematic review of levodopa dose equivalency reporting in Parkinson's disease","volume":"25","author":"Tomlinson","year":"2010","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12273-BIB0014|ane12273-cit-0014","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/mds.20216","article-title":"Risk and incidence of dementia in a cohort of older subjects with Parkinson's disease in the United Kingdom","volume":"19","author":"Hobson","year":"2004","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12273-BIB0015|ane12273-cit-0015","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1001\/archneur.64.9.1242","article-title":"The relationship of Parkinson disease with aging","volume":"64","author":"Levy","year":"2007","journal-title":"Arch Neurol"},{"key":"10.1111\/ane.12273-BIB0016|ane12273-cit-0016","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neulet.2009.02.006","article-title":"Regional differences in the severity of Lewy body pathology across the olfactory cortex","volume":"453","author":"Silveira-Moriyama","year":"2009","journal-title":"Neurosci Lett"},{"key":"10.1111\/ane.12273-BIB0017|ane12273-cit-0017","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1469-7580.2007.00748.x","article-title":"Alpha-synuclein pathology in the olfactory pathways of dementia patients","volume":"211","author":"Hubbard","year":"2007","journal-title":"J Anat"},{"key":"10.1111\/ane.12273-BIB0018|ane12273-cit-0018","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00401-010-0687-9","article-title":"Alpha-Synucleinopathy in the human olfactory system in Parkinson's disease: involvement of calcium-binding protein- and substance P-positive cells","volume":"119","author":"Ubeda-Banon","year":"2010","journal-title":"Acta Neuropathol"},{"key":"10.1111\/ane.12273-BIB0019|ane12273-cit-0019","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol Aging"},{"key":"10.1111\/ane.12273-BIB0020|ane12273-cit-0020","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1750-3639.2006.00032.x","article-title":"Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease","volume":"17","author":"Orimo","year":"2007","journal-title":"Brain Pathol"},{"key":"10.1111\/ane.12273-BIB0021|ane12273-cit-0021","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/mds.21413","article-title":"Olfactory loss may be a first sign of idiopathic Parkinson's disease","volume":"22","author":"Haehner","year":"2007","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12273-BIB0022|ane12273-cit-0022","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/ana.23659","article-title":"Neuropathologic substrates of Parkinson disease dementia","volume":"72","author":"Irwin","year":"2012","journal-title":"Ann Neurol"},{"key":"10.1111\/ane.12273-BIB0023|ane12273-cit-0023","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1212\/01.WNL.0000158422.41380.82","article-title":"Cognitive status correlates with neuropathologic stage in Parkinson disease","volume":"64","author":"Braak","year":"2005","journal-title":"Neurology"},{"key":"10.1111\/ane.12273-BIB0024|ane12273-cit-0024","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s004019900168","article-title":"Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease","volume":"100","author":"Mattila","year":"2000","journal-title":"Acta Neuropathol"},{"key":"10.1111\/ane.12273-BIB0025|ane12273-cit-0025","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00401-009-0597-x","article-title":"The morbid anatomy of dementia in Parkinson's disease","volume":"118","author":"Kalaitzakis","year":"2009","journal-title":"Acta Neuropathol"},{"key":"10.1111\/ane.12273-BIB0026|ane12273-cit-0026","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/hbm.21245","article-title":"Cognitive status correlates with white matter alteration in Parkinson's disease","volume":"33","author":"Hattori","year":"2012","journal-title":"Hum Brain Mapp"},{"key":"10.1111\/ane.12273-BIB0027|ane12273-cit-0027","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/S1474-4422(10)70212-X","article-title":"Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease","volume":"9","author":"Kehagia","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1111\/ane.12273-BIB0028|ane12273-cit-0028","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev-pathol-011110-130242","article-title":"Parkinson's disease: genetics and pathogenesis","volume":"6","author":"Shulman","year":"2011","journal-title":"Annu Rev Pathol"},{"key":"10.1111\/ane.12273-BIB0029|ane12273-cit-0029","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrneurol.2012.80","article-title":"Olfactory dysfunction in Parkinson disease","volume":"8","author":"Doty","year":"2012","journal-title":"Nat Rev Neurol"},{"key":"10.1111\/ane.12273-BIB0030|ane12273-cit-0030","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s10571-011-9780-4","article-title":"Stress, allostatic load, catecholamines, and other neurotransmitters in neurodegenerative diseases","volume":"32","author":"Goldstein","year":"2012","journal-title":"Cell Mol Neurobiol"},{"key":"10.1111\/ane.12273-BIB0031|ane12273-cit-0031","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1093\/brain\/awq079","article-title":"Olfactory dysfunction, central cholinergic integrity and cognitive impairment in Parkinson's disease","volume":"133","author":"Bohnen","year":"2010","journal-title":"Brain"},{"key":"10.1111\/ane.12273-BIB0032|ane12273-cit-0032","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/chemse\/bjh067","article-title":"Lateralization of olfactory processes","volume":"29","author":"Royet","year":"2004","journal-title":"Chem Senses"},{"key":"10.1111\/ane.12273-BIB0033|ane12273-cit-0033","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/chemse\/28.6.537","article-title":"Evidence for deficiencies in perceptual and semantic olfactory processes in Parkinson's disease","volume":"28","author":"Hudry","year":"2003","journal-title":"Chem Senses"},{"key":"10.1111\/ane.12273-BIB0034|ane12273-cit-0034","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/brain\/awr321","article-title":"Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease: a 3\u00a0year longitudinal study","volume":"135","author":"Baba","year":"2012","journal-title":"Brain"},{"key":"10.1111\/ane.12273-BIB0035|ane12273-cit-0035","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/ane.12181","article-title":"A2A adenosine receptors and Parkinson's disease severity","volume":"129","author":"Casetta","year":"2014","journal-title":"Acta Neurol Scand"}],"container-title":["Acta Neurologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fane.12273","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/ane.12273\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:47:40Z","timestamp":1671540460000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ane.12273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,11]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"URL":"https:\/\/doi.org\/10.1111\/ane.12273","relation":{},"ISSN":["0001-6314"],"issn-type":[{"value":"0001-6314","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9,11]]}}}