{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:07:23Z","timestamp":1777471643315,"version":"3.51.4"},"reference-count":36,"publisher":"Hindawi Limited","issue":"4","license":[{"start":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T00:00:00Z","timestamp":1483401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T00:00:00Z","timestamp":1483401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"HD Lorena Scarafiocca Foundation"},{"DOI":"10.13039\/501100009559","name":"National University of Quilmes","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009559","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurol Scand"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1111\/ane.12728","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T02:26:43Z","timestamp":1483496803000},"page":"322-329","source":"Crossref","is-referenced-by-count":13,"title":["Deficits in temporal processing correlate with clinical progression in Huntington's disease"],"prefix":"10.1155","volume":"136","author":[{"given":"P. V.","family":"Agostino","sequence":"first","affiliation":[{"name":"Department of Science and Technology; National University of Quilmes\/CONICET; Bernal Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. M.","family":"Gatto","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias de Buenos Aires; INEBA; Bernal Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cesarini","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias de Buenos Aires; INEBA; Bernal Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Etcheverry","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias de Buenos Aires; INEBA; Bernal Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sanguinetti","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias de Buenos Aires; INEBA; Bernal Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Golombek","sequence":"additional","affiliation":[{"name":"Department of Science and Technology; National University of Quilmes\/CONICET; Bernal Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","published-online":{"date-parts":[[2017,1,3]]},"reference":[{"key":"10.1111\/ane.12728-BIB0001|ane12728-cit-0001","volume-title":"Functional and Neural Mechanisms of Interval Timing","year":"2003"},{"key":"10.1111\/ane.12728-BIB0002|ane12728-cit-0002","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nrn1764","article-title":"What makes us tick? Functional and neural mechanisms of interval timing","volume":"6","author":"Buhusi","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1111\/ane.12728-BIB0003|ane12728-cit-0003","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cogbrainres.2004.06.012","article-title":"Cortico-striatal circuits and interval timing: coincidence-detection of oscillatory processes","volume":"21","author":"Matell","year":"2004","journal-title":"Cogn Brain Res"},{"key":"10.1111\/ane.12728-BIB0004|ane12728-cit-0004","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cobeha.2016.02.024","article-title":"Clocks within clocks: timing by coincidence detection","volume":"8","author":"Buhusi","year":"2016","journal-title":"Curr Opin Behav Sci"},{"key":"10.1111\/ane.12728-BIB0005|ane12728-cit-0005","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cobeha.2016.02.013","article-title":"Contributions of dopaminergic signaling to timing accuracy and precision","volume":"8","author":"Agostino","year":"2016","journal-title":"Curr Opin Behav Sci"},{"key":"10.1111\/ane.12728-BIB0006|ane12728-cit-0006","doi-asserted-by":"crossref","first-page":"7731","DOI":"10.1523\/JNEUROSCI.1736-07.2007","article-title":"Transient overexpression of striatal D2 receptors impairs operant motivation and interval timing","volume":"27","author":"Drew","year":"2007","journal-title":"J Neurosci"},{"key":"10.1111\/ane.12728-BIB0007|ane12728-cit-0007","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.cub.2015.02.036","article-title":"A scalable population code for time in the striatum","volume":"25","author":"Mello","year":"2015","journal-title":"Curr Biol"},{"key":"10.1111\/ane.12728-BIB0008|ane12728-cit-0008","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1162\/089892998562762","article-title":"Coupled temporal memories in Parkinson's disease: a dopamine-related dysfunction","volume":"10","author":"Malapani","year":"1998","journal-title":"J Cogn Neurosci"},{"key":"10.1111\/ane.12728-BIB0009|ane12728-cit-0009","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1093\/brain\/awr210","article-title":"Pathophysiological distortions in time perception and timed performance","volume":"135","author":"Allman","year":"2012","journal-title":"Brain"},{"key":"10.1111\/ane.12728-BIB0010|ane12728-cit-0010","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.baga.2014.06.004","article-title":"Alterations in time estimation in multiple system atrophy","volume":"4","author":"H\u00f6gl","year":"2014","journal-title":"Basal Ganglia"},{"key":"10.1111\/ane.12728-BIB0011|ane12728-cit-0011","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1162\/jocn.2011.21626","article-title":"Double dissociation of dopamine genes and timing in humans","volume":"23","author":"Wiener","year":"2011","journal-title":"J Cogn Neurosci"},{"key":"10.1111\/ane.12728-BIB0012|ane12728-cit-0012","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neuropsychologia.2012.08.002","article-title":"Epistasis effects of dopamine genes on interval timing and reward magnitude in humans","volume":"51","author":"Balci","year":"2013","journal-title":"Neuropsychologia"},{"key":"10.1111\/ane.12728-BIB0013|ane12728-cit-0013","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"The Huntington's Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"10.1111\/ane.12728-BIB0014|ane12728-cit-0014","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.pneurobio.2006.11.001","article-title":"The corticostriatal pathway in Huntington's disease","volume":"81","author":"Cepeda","year":"2007","journal-title":"Prog Neurobiol"},{"key":"10.1111\/ane.12728-BIB0015|ane12728-cit-0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-19285-7_1","article-title":"The neuropathology of Huntington\u2032s disease: classical findings, recent developments and correlation to functional neuroanatomy","volume":"217","author":"R\u00fcb","year":"2015","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"10.1111\/ane.12728-BIB0016|ane12728-cit-0016","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.parkreldis.2011.09.011","article-title":"Clinical and genetic characteristics in patients with Huntington's disease from Argentina","volume":"18","author":"Gatto","year":"2012","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1111\/ane.12728-BIB0017|ane12728-cit-0017","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/mds.25997","article-title":"Onset of Huntington's disease: can it be purely cognitive?","volume":"29","author":"Paulsen","year":"2014","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12728-BIB0018|ane12728-cit-0018","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.parkreldis.2016.04.017","article-title":"Resting-state fMRI reveals potential neural correlates of impaired cognition in Huntington's disease","volume":"27","author":"Liu","year":"2016","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1111\/ane.12728-BIB0019|ane12728-cit-0019","doi-asserted-by":"crossref","first-page":"e1263","DOI":"10.1371\/journal.pone.0001263","article-title":"Time processing in Huntington's disease: a group-control study","volume":"2","author":"Beste","year":"2007","journal-title":"PLoS One"},{"key":"10.1111\/ane.12728-BIB0020|ane12728-cit-0020","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1002\/mds.25998","article-title":"Variability in interval production is due to timing-dependent deficits in Huntington's disease","volume":"29","author":"Rao","year":"2014","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12728-BIB0021|ane12728-cit-0021","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuropsychologia.2013.09.039","article-title":"The basal ganglia in perceptual timing: timing performance in Multiple System Atrophy and Huntington's disease","volume":"52","author":"Cope","year":"2014","journal-title":"Neuropsychologia"},{"key":"10.1111\/ane.12728-BIB0022|ane12728-cit-0022","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1037\/a0018905","article-title":"Self-paced timing detects and tracks change in prodromal Huntington disease","volume":"24","author":"Rowe","year":"2010","journal-title":"Neuropsychology"},{"key":"10.1111\/ane.12728-BIB0023|ane12728-cit-0023","first-page":"1715","article-title":"fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington's disease","volume":"25","author":"Paulsen","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1111\/ane.12728-BIB0024|ane12728-cit-0024","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.870110204","article-title":"Unified Huntington's Disease Rating Scale: reliability and consistency. Huntington Study Group","volume":"11","author":"Huntington Study Group","year":"1996","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12728-BIB0025|ane12728-cit-0025","doi-asserted-by":"crossref","first-page":"789","DOI":"10.3758\/APP.71.4.789","article-title":"Expectancy in humans in multisecond peak-interval timing with gaps","volume":"71","author":"Fortin","year":"2009","journal-title":"Atten Percept Psychophys"},{"key":"10.1111\/ane.12728-BIB0026|ane12728-cit-0026","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3758\/BF03206404","article-title":"The Walter Reed palm-held psychomotor vigilance test","volume":"37","author":"Thorne","year":"2005","journal-title":"Behav Res Methods"},{"key":"10.1111\/ane.12728-BIB0027|ane12728-cit-0027","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.1111\/ane.12728-BIB0028|ane12728-cit-0028","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/gbb.12059","article-title":"Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF","volume":"12","author":"Agostino","year":"2013","journal-title":"Genes Brain Behav"},{"key":"10.1111\/ane.12728-BIB0029|ane12728-cit-0029","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.brainres.2007.10.025","article-title":"Prenatal choline supplementation increases sensitivity to time by reducing non-scalar sources of variance in adult temporal processing","volume":"1186","author":"Cheng","year":"2007","journal-title":"Brain Res"},{"key":"10.1111\/ane.12728-BIB0030|ane12728-cit-0030","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1037\/0033-295X.84.3.279","article-title":"Scalar expectancy theory and Weber's Law in animal timing","volume":"84","author":"Gibbon","year":"1977","journal-title":"Psychol Rev"},{"key":"10.1111\/ane.12728-BIB0031|ane12728-cit-0031","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1037\/a0017106","article-title":"Interval timing accuracy and scalar timing in C57BL\/6 mice","volume":"123","author":"Buhusi","year":"2009","journal-title":"Behav Neurosci"},{"key":"10.1111\/ane.12728-BIB0032|ane12728-cit-0032","doi-asserted-by":"crossref","first-page":"7487","DOI":"10.1073\/pnas.1204542109","article-title":"Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice","volume":"109","author":"Crook","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/ane.12728-BIB0033|ane12728-cit-0033","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1037\/0097-7403.24.1.15","article-title":"Scalar expectancy theory and peak-interval timing in humans","volume":"24","author":"Rakitin","year":"1998","journal-title":"Exp Psychol Anim Behav Process"},{"key":"10.1111\/ane.12728-BIB0034|ane12728-cit-0034","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.expneurol.2008.11.018","article-title":"Alterations in voluntary movement execution in Huntington's disease are related to the dominant motor system: evidence from event-related potentials","volume":"216","author":"Beste","year":"2009","journal-title":"Exp Neurol"},{"key":"10.1111\/ane.12728-BIB0035|ane12728-cit-0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jns.2015.12.037","article-title":"Reaction time and rhythm of movement in Huntington's disease","volume":"362","author":"Martinez Pueyo","year":"2016","journal-title":"J Neurol Sci"},{"key":"10.1111\/ane.12728-BIB0036|ane12728-cit-0036","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1037\/neu0000134","article-title":"Cognitive deficits predict poorer functional capacity in Huntington's disease: but what is being measured?","volume":"29","author":"Eddy","year":"2015","journal-title":"Neuropsychology"}],"container-title":["Acta Neurologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fane.12728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/ane.12728\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:50:15Z","timestamp":1671540615000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ane.12728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,3]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"URL":"https:\/\/doi.org\/10.1111\/ane.12728","archive":["Portico"],"relation":{},"ISSN":["0001-6314"],"issn-type":[{"value":"0001-6314","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,3]]}}}