{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:50:17Z","timestamp":1783792217942,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T00:00:00Z","timestamp":1490572800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T00:00:00Z","timestamp":1490572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KA 3179\/2-1"],"award-info":[{"award-number":["KA 3179\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CK 1134"],"award-info":[{"award-number":["CK 1134"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hermann and Lilly Schilling Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurol Scand"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1111\/ane.12760","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T09:42:18Z","timestamp":1490607738000},"page":"495-500","source":"Crossref","is-referenced-by-count":18,"title":["Non-motor symptoms and quality of life in subjects with mild parkinsonian signs"],"prefix":"10.1155","volume":"136","author":[{"given":"J.","family":"Prasuhn","sequence":"first","affiliation":[{"name":"Institute of Neurogenetics; University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Piskol","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics; University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.-J.","family":"Vollstedt","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics; University of L\u00fcbeck; L\u00fcbeck Germany"},{"name":"Department of Psychiatry and Psychotherapy; University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Graf","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics; University of L\u00fcbeck; L\u00fcbeck Germany"},{"name":"Department of Neurology; University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics; University of L\u00fcbeck; L\u00fcbeck Germany"},{"name":"Kurt Singer Institute for Music Physiology and Musicians\u2019 Health; Hanns Eisler School of Music Berlin; Berlin Germany"},{"name":"Berlin Center for Musicians\u2019 Medicine; Charit\u00e9 - University Medicine Berlin; Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Tadic","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics; University of L\u00fcbeck; L\u00fcbeck Germany"},{"name":"Department of Neurology; University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tunc","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics; University of L\u00fcbeck; L\u00fcbeck Germany"},{"name":"Department of Neurology; University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hampf","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics; University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Warrlich","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics; University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bibergeil","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics; University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hagenah","sequence":"additional","affiliation":[{"name":"Department of Neurology; Westk\u00fcstenklinikum Heide; Heide Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Klein","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics; University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kasten","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics; University of L\u00fcbeck; L\u00fcbeck Germany"},{"name":"Department of Psychiatry and Psychotherapy; University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5969-6899","authenticated-orcid":false,"given":"N.","family":"Br\u00fcggemann","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics; University of L\u00fcbeck; L\u00fcbeck Germany"},{"name":"Department of Neurology; University of L\u00fcbeck; L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,27]]},"reference":[{"key":"10.1111\/ane.12760-BIB0001|ane12760-cit-0001","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/jnnp.51.6.745","article-title":"The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease","volume":"51","author":"Gibb","year":"1988","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1111\/ane.12760-BIB0002|ane12760-cit-0002","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12760-BIB0003|ane12760-cit-0003","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol Aging"},{"key":"10.1111\/ane.12760-BIB0004|ane12760-cit-0004","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00441-004-0956-9","article-title":"Stages in the development of Parkinson's disease-related pathology","volume":"318","author":"Braak","year":"2004","journal-title":"Cell Tissue Res"},{"key":"10.1111\/ane.12760-BIB0005|ane12760-cit-0005","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/mds.24996","article-title":"Identifying prodromal Parkinson's disease: pre-motor disorders in Parkinson's disease","volume":"27","author":"Postuma","year":"2012","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12760-BIB0006|ane12760-cit-0006","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/ane.12620","article-title":"Sleeping difficulties and health-related quality of life in Parkinson's disease","volume":"135","author":"Ylikoski","year":"2017","journal-title":"Acta Neurol Scand"},{"key":"10.1111\/ane.12760-BIB0007|ane12760-cit-0007","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1002\/mds.21433","article-title":"Mild Parkinsonian signs: an overview of an emerging concept","volume":"22","author":"Louis","year":"2007","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12760-BIB0008|ane12760-cit-0008","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.parkreldis.2014.11.018","article-title":"Reasons for mild parkinsonian signs - which constellation may indicate neurodegeneration?","volume":"21","author":"Lerche","year":"2015","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1111\/ane.12760-BIB0009|ane12760-cit-0009","doi-asserted-by":"crossref","first-page":"e92878","DOI":"10.1371\/journal.pone.0092878","article-title":"Mild parkinsonian signs in the elderly - is there an association with PD? Crossectional findings in 992 individuals","volume":"9","author":"Lerche","year":"2014","journal-title":"PLoS One"},{"key":"10.1111\/ane.12760-BIB0010|ane12760-cit-0010","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/mds.26431","article-title":"MDS research criteria for prodromal Parkinson's disease","volume":"30","author":"Berg","year":"2015","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12760-BIB0011|ane12760-cit-0011","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1002\/mds.23368","article-title":"Nonmotor symptoms are independently associated with impaired health-related quality of life in Chinese patients with Parkinson's disease","volume":"25","author":"Li","year":"2010","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12760-BIB0012|ane12760-cit-0012","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/mds.24999","article-title":"Depression and quality of life in monogenic compared to idiopathic, early-onset Parkinson's disease","volume":"27","author":"Kasten","year":"2012","journal-title":"Mov Disord"},{"key":"10.1111\/ane.12760-BIB0013|ane12760-cit-0013","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.parkreldis.2013.12.014","article-title":"Non-motor phenotype of dopa-responsive dystonia and quality of life assessment","volume":"20","author":"Bruggemann","year":"2014","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1111\/ane.12760-BIB0014|ane12760-cit-0014","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/ije\/dys202","article-title":"Cohort Profile: a population-based cohort to study non-motor symptoms in parkinsonism (EPIPARK)","volume":"42","author":"Kasten","year":"2013","journal-title":"Int J Epidemiol"},{"key":"10.1111\/ane.12760-BIB0015|ane12760-cit-0015","doi-asserted-by":"crossref","first-page":"961372","DOI":"10.1155\/2015\/961372","article-title":"Qualitative characteristics of depression in Parkinson's patients and controls","volume":"2015","author":"Kritzinger","year":"2015","journal-title":"Behav Neurol"},{"key":"10.1111\/ane.12760-BIB0016|ane12760-cit-0016","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s004150050312","article-title":"Validation of a mail questionnaire for parkinsonism in two languages (German and Italian)","volume":"246","author":"Pramstaller","year":"1999","journal-title":"J Neurol"},{"key":"10.1111\/ane.12760-BIB0017|ane12760-cit-0017","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.1111\/ane.12760-BIB0018|ane12760-cit-0018","unstructured":"Bartusch SM Zipper S Moneal Cognitive Assessment (MOCA) - deutsche \u00dcbersetzung 2004 http:\/\/wwwmocatestorg\/pdf_files\/test\/MOCA-Test"},{"key":"10.1111\/ane.12760-BIB0019|ane12760-cit-0019","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1207\/s15327752jpa6703_13","article-title":"Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients","volume":"67","author":"Beck","year":"1996","journal-title":"J Pers Assess"},{"key":"10.1111\/ane.12760-BIB0020|ane12760-cit-0020","volume-title":"Beck Depressions-Inventar (BDI-II). Revision","author":"Hautzinger","year":"2006"},{"key":"10.1111\/ane.12760-BIB0021|ane12760-cit-0021","volume-title":"Manual for the State-Trait Anxiety Inventory","author":"Spielberger","year":"1983"},{"key":"10.1111\/ane.12760-BIB0022|ane12760-cit-0022","volume-title":"Das State-Trait-Angstinventar (Testmappe mit Handanweisung, Fragebogen STAI-G Form X 1 und Fragebogen STAI-G Form X 2)","author":"Laux","year":"1981"},{"key":"10.1111\/ane.12760-BIB0023|ane12760-cit-0023","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A new method for measuring daytime sleepiness: the Epworth sleepiness scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"key":"10.1111\/ane.12760-BIB0024|ane12760-cit-0024","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1159\/000029408","article-title":"German version of the Epworth Sleepiness Scale","volume":"66","author":"Bloch","year":"1999","journal-title":"Respiration"},{"key":"10.1111\/ane.12760-BIB0025|ane12760-cit-0025","first-page":"44","article-title":"Deutschsprachige Version der WHO Instrumente zur Erfassung von Lebensqualit\u00e4t WHOQOL-100 undWHOQOL-BREFM","volume":"11","author":"Angermeyer","year":"2002","journal-title":"Z Med Psychol"},{"key":"10.1111\/ane.12760-BIB0026|ane12760-cit-0026","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrneurol.2011.189","article-title":"Depression in Parkinson disease - epidemiology, mechanisms and management","volume":"8","author":"Aarsland","year":"2012","journal-title":"Nat Rev Neurol"},{"key":"10.1111\/ane.12760-BIB0027|ane12760-cit-0027","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.parkreldis.2016.02.011","article-title":"Association between cerebral small vessel diseases and mild parkinsonian signs in the elderly with vascular risk factors","volume":"26","author":"Hatate","year":"2016","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1111\/ane.12760-BIB0028|ane12760-cit-0028","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000444021","article-title":"Age, gender, comorbidity, and the MDS-UPDRS: Results from a population-based study","volume":"46","author":"Keezer","year":"2016","journal-title":"Neuroepidemiology"},{"key":"10.1111\/ane.12760-BIB0029|ane12760-cit-0029","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1212\/01.WNL.0000156157.97411.5E","article-title":"Association between mild parkinsonian signs and mild cognitive impairment in a community","volume":"64","author":"Louis","year":"2005","journal-title":"Neurology"},{"key":"10.1111\/ane.12760-BIB0030|ane12760-cit-0030","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jns.2016.01.016","article-title":"Longitudinal course of mild parkinsonian signs in elderly people: a population-based study in Japan","volume":"362","author":"Wada-Isoe","year":"2016","journal-title":"J Neurol Sci"},{"key":"10.1111\/ane.12760-BIB0031|ane12760-cit-0031","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1212\/WNL.54.5.21A","article-title":"Prevalence of Parkinson's disease in Europe: a collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group","volume":"54","author":"Rijk","year":"2000","journal-title":"Neurology"},{"key":"10.1111\/ane.12760-BIB0032|ane12760-cit-0032","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1001\/archneur.62.2.297","article-title":"Functional correlates and prevalence of mild parkinsonian signs in a community population of older people","volume":"62","author":"Louis","year":"2005","journal-title":"Arch Neurol"},{"key":"10.1111\/ane.12760-BIB0033|ane12760-cit-0033","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1007\/s00415-014-7442-4","article-title":"The evolution of mild parkinsonian signs in aging","volume":"261","author":"Mahoney","year":"2014","journal-title":"J Neurol"},{"key":"10.1111\/ane.12760-BIB0034|ane12760-cit-0034","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/ane.12089","article-title":"Depression and cognitive impairment in patients with mild parkinsonian signs","volume":"128","author":"Uemura","year":"2013","journal-title":"Acta Neurol Scand"},{"key":"10.1111\/ane.12760-BIB0035|ane12760-cit-0035","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1136\/jnnp.2003.020982","article-title":"Are men at greater risk for Parkinson's disease than women?","volume":"75","author":"Wooten","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1111\/ane.12760-BIB0036|ane12760-cit-0036","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/aje\/kwg068","article-title":"Incidence of Parkinson's disease: variation by age, gender, and race\/ethnicity","volume":"157","author":"Van Den Eeden","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.1111\/ane.12760-BIB0037|ane12760-cit-0037","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1474-4422(14)70287-X","article-title":"Prediagnostic presentations of Parkinson's disease in primary care: a case-control study","volume":"14","author":"Schrag","year":"2015","journal-title":"Lancet Neurol"}],"container-title":["Acta Neurologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fane.12760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/ane.12760\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:50:24Z","timestamp":1671540624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ane.12760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,27]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"URL":"https:\/\/doi.org\/10.1111\/ane.12760","archive":["Portico"],"relation":{},"ISSN":["0001-6314"],"issn-type":[{"value":"0001-6314","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3,27]]}}}