{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T17:32:28Z","timestamp":1771867948502,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T00:00:00Z","timestamp":1510876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T00:00:00Z","timestamp":1510876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurol Scand"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1111\/ane.12869","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T09:32:34Z","timestamp":1510911154000},"page":"329-334","source":"Crossref","is-referenced-by-count":19,"title":["Late age onset of amyotrophic lateral sclerosis is often not considered in elderly people"],"prefix":"10.1155","volume":"137","author":[{"given":"E.","family":"Broussalis","sequence":"first","affiliation":[{"name":"Department of Neurology; Christian-Doppler-Klinik; Paracelsus Medical University and Salzburger Landeskliniken; Salzburg Austria"},{"name":"Department of Neuroradiology; Christian-Doppler-Klinik; Paracelsus Medical University and Salzburger Landeskliniken; Salzburg Austria"},{"name":"Research Institute of Neurointervention; Paracelsus Medical University; Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Grinzinger","sequence":"additional","affiliation":[{"name":"Department of Neurology; Christian-Doppler-Klinik; Paracelsus Medical University and Salzburger Landeskliniken; Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. B.","family":"Kunz","sequence":"additional","affiliation":[{"name":"Department of Neurology; Christian-Doppler-Klinik; Paracelsus Medical University and Salzburger Landeskliniken; Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Killer-Oberpfalzer","sequence":"additional","affiliation":[{"name":"Department of Neurology; Christian-Doppler-Klinik; Paracelsus Medical University and Salzburger Landeskliniken; Salzburg Austria"},{"name":"Research Institute of Neurointervention; Paracelsus Medical University; Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Haschke-Becher","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine; Paracelsus Medical University and Salzburger Landeskliniken; Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.-P.","family":"Hartung","sequence":"additional","affiliation":[{"name":"Department of Neurology; Heinrich Heine University of D\u00fcsseldorf; Medical Faculty; D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3637-611X","authenticated-orcid":false,"given":"J.","family":"Kraus","sequence":"additional","affiliation":[{"name":"Research Institute of Neurointervention; Paracelsus Medical University; Salzburg Austria"},{"name":"Department of Laboratory Medicine; Paracelsus Medical University and Salzburger Landeskliniken; Salzburg Austria"},{"name":"Department of Neurology; Heinrich Heine University of D\u00fcsseldorf; Medical Faculty; D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,17]]},"reference":[{"key":"10.1111\/ane.12869-BIB0001|ane12869-cit-0001","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S1474-4422(13)70036-X","article-title":"Controversies and priorities in amyotrophic lateral sclerosis","volume":"12","author":"Turner","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1111\/ane.12869-BIB0002|ane12869-cit-0002","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0025-6196(12)61175-6","article-title":"Motor neuron disease (amyotrophic lateral sclerosis)","volume":"66","author":"Williams","year":"1991","journal-title":"Mayo Clin Proc"},{"key":"10.1111\/ane.12869-BIB0003|ane12869-cit-0003","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/mus.880121008","article-title":"Survival prediction in amyotrophic lateral sclerosis","volume":"12","author":"Jablecki","year":"1989","journal-title":"Muscle Nerve"},{"key":"10.1111\/ane.12869-BIB0004|ane12869-cit-0004","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/ane.12713","article-title":"The concept and diagnostic criteria of primary lateral sclerosis","volume":"136","author":"Wais","year":"2016","journal-title":"Acta Neurol Scand"},{"key":"10.1111\/ane.12869-BIB0005|ane12869-cit-0005","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/ane.12471","article-title":"Motor function and behaviour across the ALS-FTD spectrum","volume":"133","author":"Silva","year":"2016","journal-title":"Acta Neurol Scand"},{"key":"10.1111\/ane.12869-BIB0006|ane12869-cit-0006","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/ane.12774","article-title":"A prospective study of quality of life in amyotrophic lateral sclerosis patients","volume":"136","author":"Jakobsson Larsson","year":"2017","journal-title":"Acta Neurol Scand"},{"key":"10.1111\/ane.12869-BIB0007|ane12869-cit-0007","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.pneurobio.2016.05.004","article-title":"ALS: a bucket of genes, environment, metabolism and unknown ingredients","volume":"142","author":"Zufiria","year":"2016","journal-title":"Prog Neurobiol"},{"key":"10.1111\/ane.12869-BIB0008|ane12869-cit-0008","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/ane.12470","article-title":"Intrafamilial clinical variability in individuals carrying the CHCHD10 mutation Gly66Val","volume":"133","author":"Pasanen","year":"2016","journal-title":"Acta Neurol Scand"},{"key":"10.1111\/ane.12869-BIB0009|ane12869-cit-0009","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nn.3584","article-title":"State of play in amyotrophic lateral sclerosis genetics","volume":"17","author":"Renton","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1111\/ane.12869-BIB0010|ane12869-cit-0010","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/ane.12463","article-title":"Investigation of vitamin D receptor polymorphisms in amyotrophic lateral sclerosis","volume":"133","author":"T\u00f6r\u00f6k","year":"2016","journal-title":"Acta Neurol Scand"},{"issue":"Suppl 2","key":"10.1111\/ane.12869-BIB0011|ane12869-cit-0011","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/BF03160574","article-title":"Glutamate, excitotoxicity and amyotrophic lateral sclerosis","volume":"244","author":"Shaw","year":"1997","journal-title":"J Neurol"},{"key":"10.1111\/ane.12869-BIB0012|ane12869-cit-0012","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1056\/NEJM199403033300901","article-title":"A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS\/Riluzole Study Group","volume":"330","author":"Bensimon","year":"1994","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"10.1111\/ane.12869-BIB0013|ane12869-cit-0013","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1080\/146608200300079987","article-title":"Problems in shortening the time to confirmation of ALS diagnosis: lessons from the 1st Consensus Conference, Chicago, May 1998","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"10.1111\/ane.12869-BIB0014|ane12869-cit-0014","first-page":"57","article-title":"Variation in worldwide incidence of amyotrophic lateral sclerosis: a meta-analysis","volume":"46","author":"Marin","year":"2016","journal-title":"Int J Epidemiol"},{"key":"10.1111\/ane.12869-BIB0015|ane12869-cit-0015","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000351153","article-title":"Global epidemiology of amyotrophic lateral sclerosis: a systematic review of the published literature","volume":"41","author":"Chio","year":"2013","journal-title":"Neuroepidemiology"},{"key":"10.1111\/ane.12869-BIB0016|ane12869-cit-0016","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1001\/archneurol.2009.13","article-title":"Amyotrophic lateral sclerosis in Sweden, 1991-2005","volume":"66","author":"Fang","year":"2009","journal-title":"Arch Neurol"},{"key":"10.1111\/ane.12869-BIB0017|ane12869-cit-0017","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1017\/S0317167100005813","article-title":"ALS incidence in Nova Scotia over a 20-year-period: a prospective study","volume":"34","author":"Bonaparte","year":"2007","journal-title":"Can J Neurol Sci"},{"key":"10.1111\/ane.12869-BIB0018|ane12869-cit-0018","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1007\/s00415-016-8215-z","article-title":"Age-period-cohort analysis of trends in amyotrophic lateral sclerosis incidence","volume":"263","author":"Tobin","year":"2016","journal-title":"J Neurol"},{"key":"10.1111\/ane.12869-BIB0019|ane12869-cit-0019","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neuro.2016.06.015","article-title":"Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis","volume":"61","author":"Wang","year":"2016","journal-title":"Neurotoxicology"},{"key":"10.1111\/ane.12869-BIB0020|ane12869-cit-0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1750-1172-4-3","article-title":"Amyotrophic lateral sclerosis","volume":"4","author":"Wijesekera","year":"2009","journal-title":"Orphanet J Rare Dis"},{"key":"10.1111\/ane.12869-BIB0021|ane12869-cit-0021","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1212\/WNL.56.2.239","article-title":"Incidence of ALS in Italy: evidence for a uniform frequency in Western countries","volume":"56","author":"Piemonte, Valle D'aosta Register For Amyotrophic Lateral S","year":"2001","journal-title":"Neurology"},{"key":"10.1111\/ane.12869-BIB0022|ane12869-cit-0022","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1212\/WNL.52.3.504","article-title":"Incidence and prevalence of ALS in Ireland, 1995-1997: a population-based study","volume":"52","author":"Traynor","year":"1999","journal-title":"Neurology"},{"key":"10.1111\/ane.12869-BIB0023|ane12869-cit-0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/21678421.2016.1187175","article-title":"Amyotrophic lateral sclerosis: A higher than expected incidence in people over 80\u00a0years of age","volume":"17","author":"Aragones","year":"2016","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"10.1111\/ane.12869-BIB0024|ane12869-cit-0024","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1136\/jnnp.2004.039180","article-title":"Incidence of amyotrophic lateral sclerosis in southern Italy: a population based study","volume":"76","author":"Logroscino","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1111\/ane.12869-BIB0025|ane12869-cit-0025","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0140-6736(15)01124-1","article-title":"Alzheimer's disease","volume":"388","author":"Scheltens","year":"2016","journal-title":"The Lancet"},{"key":"10.1111\/ane.12869-BIB0026|ane12869-cit-0026","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/ane.12789","article-title":"Controlled population-based comparative study of USA and international adult [55-74] neurological deaths 1989-2014","volume":"136","author":"Pritchard","year":"2017","journal-title":"Acta Neurol Scand"},{"key":"10.1111\/ane.12869-BIB0027|ane12869-cit-0027","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"10.1111\/ane.12869-BIB0028|ane12869-cit-0028","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1212\/WNL.0000000000002912","article-title":"Motor cortical function determines prognosis in sporadic ALS","volume":"87","author":"Shibuya","year":"2016","journal-title":"Neurology"},{"key":"10.1111\/ane.12869-BIB0029|ane12869-cit-0029","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1086\/425287","article-title":"A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis","volume":"75","author":"Nishimura","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1111\/ane.12869-BIB0030|ane12869-cit-0030","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.genm.2010.11.010","article-title":"Effects of gender in amyotrophic lateral sclerosis","volume":"7","author":"McCombe","year":"2010","journal-title":"Gend Med"},{"key":"10.1111\/ane.12869-BIB0031|ane12869-cit-0031","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/ageing\/afh013","article-title":"The epidemiology of amyotrophic lateral sclerosis (ALS\/MND) in people aged 80 or over","volume":"33","author":"Forbes","year":"2004","journal-title":"Age Ageing"},{"key":"10.1111\/ane.12869-BIB0032|ane12869-cit-0032","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/mus.880160107","article-title":"Duration of amyotrophic lateral sclerosis is age dependent","volume":"16","author":"Eisen","year":"1993","journal-title":"Muscle Nerve"},{"key":"10.1111\/ane.12869-BIB0033|ane12869-cit-0033","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000369813","article-title":"Epidemiology of amyotrophic lateral sclerosis and effect of riluzole on disease course","volume":"44","author":"Cetin","year":"2015","journal-title":"Neuroepidemiology"},{"key":"10.1111\/ane.12869-BIB0034|ane12869-cit-0034","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1159\/000110384","article-title":"Prognostic factors and survival in amyotrophic lateral sclerosis","volume":"13","author":"Tysnes","year":"1994","journal-title":"Neuroepidemiology"},{"key":"10.1111\/ane.12869-BIB0035|ane12869-cit-0035","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1212\/WNL.0000000000003298","article-title":"Race\/ethnicity, socioeconomic status, and ALS mortality in the United States","volume":"87","author":"Roberts","year":"2016","journal-title":"Neurology"},{"key":"10.1111\/ane.12869-BIB0036|ane12869-cit-0036","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jns.2005.05.013","article-title":"Discussing living wills. A qualitative study of a German sample of neurologists and ALS patients","volume":"237","author":"Burchardi","year":"2005","journal-title":"J Neurol Sci"},{"key":"10.1111\/ane.12869-BIB0037|ane12869-cit-0037","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.annemergmed.2010.04.015","article-title":"Older patients in the emergency department: a review","volume":"56","author":"Samaras","year":"2010","journal-title":"Ann Emerg Med"},{"key":"10.1111\/ane.12869-BIB0038|ane12869-cit-0038","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1590\/S0004-282X2009000400040","article-title":"Amyotrophic lateral sclerosis (ALS): three letters that change the people's life. For ever","volume":"67","author":"Oliveira","year":"2009","journal-title":"Arq Neuropsiquiatr"},{"key":"10.1111\/ane.12869-BIB0039|ane12869-cit-0039","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/21678421.2014.964258","article-title":"The El Escorial criteria: strengths and weaknesses","volume":"16","author":"Agosta","year":"2015","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"10.1111\/ane.12869-BIB0040|ane12869-cit-0040","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3109\/21678421.2015.1049183","article-title":"A revision of the El Escorial criteria - 2015","volume":"16","author":"Ludolph","year":"2015","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"}],"container-title":["Acta Neurologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fane.12869","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/ane.12869\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:51:01Z","timestamp":1671540661000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ane.12869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,17]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"URL":"https:\/\/doi.org\/10.1111\/ane.12869","archive":["Portico"],"relation":{},"ISSN":["0001-6314"],"issn-type":[{"value":"0001-6314","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11,17]]}}}