{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:39:56Z","timestamp":1762979996478},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T00:00:00Z","timestamp":1369699200000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Brugada syndrome (BrS) includes a group of patients with a typical pattern of ST segment elevation in right precordial leads who are at risk for sudden cardiac death. The electrocardiogram pattern may be intermittent and unmasked by sodium channel blockers. The main objective of this study is to describe a serie of consecutive patients in whom oral administration of flecainide was used to unmask BrS type I electrocardiographic pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively studied 14 symptomatic (palpitations\/syncope) patients referred to our laboratory presenting a suggestive but not diagnostic Brugada ECG or family history of sudden death. Single oral dose of flecainide 400 mg was administered. Resting 12\u2010lead ECG with upper and standard right precordial leads were performed after flecainide administration at 15, 30, 60 and 90 min and hourly until ECG became normal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age was 37.5 years (range\u00a0= 22\u201350). None of them had structural heart disease. In 7 patients (50%) the typical coved\u2010type ECG pattern of BrS was unmasked. PR interval, QRS duration and QTc median difference after\u2010before test was 20 msec (min\u2013max\u00a0= \u221217\u2013+57), 21 ms (min\u2013max\u00a0= 0 to +59) and 20 ms (min\u2013max\u00a0= \u221211\u2013+77), respectively. There were no episodes of AV block, atrial or ventricular tachyarrhythmia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our experience we found that oral administration of flecainide in a single dose of 400 mg is useful to unmask type 1 Brugada electrocardiographic pattern.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12052","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T06:58:41Z","timestamp":1369810721000},"page":"256-261","source":"Crossref","is-referenced-by-count":15,"title":["Single Oral Flecainide Dose to Unmask Type 1 Brugada Syndrome Electrocardiographic Pattern"],"prefix":"10.1111","volume":"18","author":[{"given":"Sergio","family":"Dubner","sequence":"first","affiliation":[{"name":"Cl\u00ednica y Maternidad Suizo Argentina and Sanatorio de los Arcos  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dami\u00e1n","family":"Azocar","sequence":"additional","affiliation":[{"name":"Cl\u00ednica y Maternidad Suizo Argentina and Sanatorio de los Arcos  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebasti\u00e1n","family":"Gallino","sequence":"additional","affiliation":[{"name":"Cl\u00ednica y Maternidad Suizo Argentina and Sanatorio de los Arcos  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso Rafael","family":"Cerantonio","sequence":"additional","affiliation":[{"name":"Cl\u00ednica y Maternidad Suizo Argentina and Sanatorio de los Arcos  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Muryan","sequence":"additional","affiliation":[{"name":"Cl\u00ednica y Maternidad Suizo Argentina and Sanatorio de los Arcos  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Medrano","sequence":"additional","affiliation":[{"name":"Cl\u00ednica y Maternidad Suizo Argentina and Sanatorio de los Arcos  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Bruno","sequence":"additional","affiliation":[{"name":"Cl\u00ednica y Maternidad Suizo Argentina and Sanatorio de los Arcos  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000152479.54298.51"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-8932(09)73082-9"},{"issue":"19","key":"e_1_2_6_4_1","first-page":"e98","article-title":"Value and safety of oral administration of flecainide stress test to unmask type 1 Brugada","volume":"125","author":"Dubner S","year":"2012","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000153267.21278.8D"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1986.tb02892.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90501-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00195-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eup189"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02193.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2004.11.025"},{"issue":"1","key":"e_1_2_6_12_1","first-page":"97","article-title":"The management of Brugada syndrome patients","volume":"14","author":"Riera AR","year":"2007","journal-title":"Cardiol J"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2007.00589.x"},{"issue":"2","key":"e_1_2_6_14_1","first-page":"130","article-title":"Propofol infusion syndrome and Brugada syndrome electrocardiographic phenocopy","volume":"17","author":"Riera AR","year":"2010","journal-title":"Cardiol J"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000034169.45752.4A"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.962936"},{"key":"e_1_2_6_17_1","first-page":"e47","article-title":"Single oral Flecainide dose to Unmask Type 1 Brugada Syndrome electrocardiographic pattern. 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