{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:29:55Z","timestamp":1780572595172,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T00:00:00Z","timestamp":1398297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>QT interval prolongation in patients with end\u2010stage liver disease (ESLD) is common. However, electrolyte abnormalities, renal insufficiency, treatment with QT\u2010prolonging drugs, and other factors known to prolong QT interval independently of liver disease occur frequently in ESLD. Moreover, elevated heart rate may be present in ESLD and result in spurious QTc prolongation if the Bazett formula is used for rate correction. It thus remains unclear whether QT prolongation in ESLD is directly caused by liver failure, or indirectly by these confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of all patients (n = 437) who received orthotopic liver transplantation (OLTx) at our institution between 2008 and 2011 were reviewed. Data from 51 patients with available pre\u2010OLTx dobutamine stress echo (DSE), post\u2010OLTx ECG and without nonhepatic factors affecting QT interval duration were analyzed. For each patient, QT versus RR regression line was calculated from ECG tracings obtained during DSE. The QT interval on post\u2010OLTx ECG was compared with the pre\u2010OLTx QT predicted by the regression line for the same RR interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>QT interval shortened significantly post\u2010OLTx (from 394 \u00b1 47 to 364 \u00b1 45 ms at RR interval 750 \u00b1 144 ms; P &lt; 0.002) when compared using the regression method. Corrected QT intervals calculated by Bazett and Fridericia formulas also shortened. Patients with prolonged QT pre\u2010OLTx had significantly higher INR and lower serum albumin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ESLD impairs ventricular repolarization even in the absence of other known factors affecting repolarization. QT prolongation in ESLD is associated with impaired synthetic liver function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12161","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T13:40:25Z","timestamp":1398346825000},"page":"574-581","source":"Crossref","is-referenced-by-count":5,"title":["QT Interval Prolongation in End\u2010Stage Liver Disease Cannot Be Explained by Nonhepatic Factors"],"prefix":"10.1111","volume":"19","author":[{"given":"Divyang","family":"Patel","sequence":"first","affiliation":[{"name":"University of Pittsburgh School of Medicine  Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine University of Pittsburgh Medical Center Pittsburgh  PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Katz","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine  Pittsburgh PA"},{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center  Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Hughes","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine  Pittsburgh PA"},{"name":"Starzl Transplantation Institute Department of Surgery University of Pittsburgh Medical Center  Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapil","family":"Chopra","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine  Pittsburgh PA"},{"name":"Division of Gastroenterology Hepatology, and Nutrition University of Pittsburgh Medical Center  Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"N\u011bmec","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine  Pittsburgh PA"},{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center  Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,24]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"263","article-title":"[Ventricular tachycardia with 2 variable opposing foci]","volume":"59","author":"Dessertenne F","year":"1966","journal-title":"Arch Mal Coeur Vaiss"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(83)80226-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/384080a0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjr.0000173110.21851.a9"},{"key":"e_1_2_8_6_1","first-page":"1191","article-title":"[Ventricular tachycardia \u201cwith reversal of points\u201d and electrolyte disorders]","volume":"107","author":"Klauser H","year":"1977","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.12.2170"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.6002\/ect.2011.0117"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-106-5-712"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01405.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1069279"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01468-1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2009.01.005"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200110000-00025"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03534.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0676.2003.00833.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960221013"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.39.321"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90879-L"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510270106"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230529"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92417-E"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00217-3"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1089-3261(05)70127-6"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.1.9"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1996.tb03191.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90562-D"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00622.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.3.220"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016393328485"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00860.2001"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00927-2"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-1603-3"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199808270-00021"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840220114"},{"key":"e_1_2_8_36_1","first-page":"539412","article-title":"The end\u2010organ impairment in liver cirrhosis: Appointments for critical care","volume":"2012","author":"Figueiredo A","year":"2012","journal-title":"Crit Care Res Pract"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.11.012"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2003.10.026"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.10.012"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70180-6"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.02.043"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00538.2007"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1978.tb00646.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01990384"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80022-6"},{"key":"e_1_2_8_46_1","first-page":"G537","article-title":"Potassium currents in atrial and ventricular myocytes from a rat model of cirrhosis","volume":"273","author":"Ward CA","year":"1997","journal-title":"Am J Physiol"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28653"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1992.tb00703.x"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.10.054"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20801"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)62209-X"}],"container-title":["Annals of Noninvasive Electrocardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanec.12161","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.12161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T04:15:43Z","timestamp":1696392943000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/anec.12161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,24]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/anec.12161"],"URL":"https:\/\/doi.org\/10.1111\/anec.12161","archive":["Portico"],"relation":{},"ISSN":["1082-720X","1542-474X"],"issn-type":[{"value":"1082-720X","type":"print"},{"value":"1542-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,24]]}}}