{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T13:57:14Z","timestamp":1761400634933,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:00:00Z","timestamp":1398038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Faculty of Medicine Endowment Fund for medical research, Chiang Mai University, Thailand"},{"name":"National Research University Project under Thailands Office of the Higher Education Commission"},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"crossref","award":["MRG 5380258, MRG 5280169, RTA 5580006"],"award-info":[{"award-number":["MRG 5380258, MRG 5280169, RTA 5580006"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A higher prevalence of QT prolongation has been reported among human immunodeficiency virus (HIV)\u2010infected patients. Previous studies have demonstrated that QT dispersion is a better predictor of serious ventricular tachyarrhythmia and cardiac mortality than corrected QT (QTc) interval. However, data of QT dispersion in HIV\u2010infected patients receiving a combined antiretroviral therapy (cART) is limited. We sought to assess QTc interval and QT dispersion in HIV\u2010infected patients receiving cART. The association between QT parameters and heart rate variability (HRV) was also examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010one HIV\u2010infected patients receiving cART (male = 33, mean age = 44 \u00b1 10 years) and 70 HIV\u2010seronegative subjects (male = 25, mean age = 44 \u00b1 8 years) were enrolled in the study. In a resting 12\u2010lead electrocardiogram, QT interval was measured by the tangent method in all leads with well\u2010defined T waves. The QT dispersion was defined as the difference between maximum and minimum QTc intervals in any of 12 leads.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The baseline characteristics were not different between the two groups. We demonstrated the significantly longer mean QTc interval (420 \u00b1 21 vs. 409 \u00b1 21 ms, P &lt; 0.001), and greater QT dispersion in HIV\u2010infected group compared to the control group (85 \u00b1 29 vs. 55 \u00b1 23 ms, P &lt; 0.001). Among the HIV\u2010infected patients, those who had lower CD4 lymphocyte count (&lt;350 cells\/mm<jats:sup>3<\/jats:sup>) tended to have greater QT dispersion (92 \u00b1 28 vs. 81 \u00b1 29 ms, P = 0.098). There were no associations between QT parameters and either HRV or cART regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HIV\u2010infected patients receiving cART were associated with prolonged QTc interval and increased QT dispersion, independent of autonomic dysfunction and antiretroviral drugs, which may have led to the potentially higher risk of ventricular arrhythmia and cardiac mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12162","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T10:58:55Z","timestamp":1398077935000},"page":"561-566","source":"Crossref","is-referenced-by-count":13,"title":["QT Dispersion in HIV\u2010Infected Patients Receiving Combined Antiretroviral Therapy"],"prefix":"10.1111","volume":"19","author":[{"given":"Wanwarang","family":"Wongcharoen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Chiang Mai University  Chiang Mai Thailand"},{"name":"Cardiac Electrophysiology Research and Training Center Chiang Mai University  Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somkhuan","family":"Suaklin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nualnit","family":"Tantisirivit","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arintaya","family":"Phrommintikul","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chiang Mai University  Chiang Mai Thailand"},{"name":"Cardiac Electrophysiology Research and Training Center Chiang Mai University  Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nipon","family":"Chattipakorn","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Research and Training Center Chiang Mai University  Chiang Mai Thailand"},{"name":"Department of Physiology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31818ceaa4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062744"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31817efb54"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.029"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.024"},{"key":"e_1_2_6_7_1","first-page":"1657","article-title":"QTc interval 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