{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T11:53:20Z","timestamp":1765886000477},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T00:00:00Z","timestamp":1429228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Radiation Effects Research Foundation (RERF)"},{"name":"Japanese Ministry of Health, Labour and Welfare (MHLW)"},{"name":"U.S. Department of Energy (DOE)"},{"name":"RERF Research Protocol","award":["RP-A13-08"],"award-info":[{"award-number":["RP-A13-08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although ventricular premature contraction (VPC) commonly arises in subjects with and without heart diseases, the prognosis of VPC has remained controversial and the effect of their morphology on mortality has not been fully determined in subjects without obvious heart diseases. The objective of this study was to assess the morphologic effect of VPC on mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Japanese atomic bomb survivors (n = 6685) underwent baseline health examinations and standard 12\u2010lead electrocardiogram (ECG) between January 1990 and December 1991. Of these, we extracted data from 5,685 (67.1% women) subjects who had neither heart diseases nor electrocardiographic abnormalities at baseline. Among them, we identified 131 VPC cases using standard 12\u2010lead ECG and classified them into left bundle branch block (LBBB) type (n = 74), right bundle branch block (RBBB) type (n = 21), and undetermined type (n = 36) according to their morphology. These subjects were followed up until December 2008; we compared all\u2010cause, cardiac and coronary heart disease (CHD) mortality rates using multivariate Cox regression analysis between those with and without VPC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No VPCs were associated with all\u2010cause and cardiac mortality, but the LBBB type was significantly associated with CHD mortality (hazard ratio, 2.73; 95% confidence interval, 1.11\u20136.73) after controlling for age, sex, smoking status, alcohol consumption, and underlying diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among Japanese atomic bomb survivors without obvious heart diseases, LBBB\u2010type VPC was associated with increased CHD mortality. Larger studies are needed to confirm the effect of morphology as it might help to predict the risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12275","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T08:12:53Z","timestamp":1429258373000},"page":"142-151","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic Significance of Premature Ventricular Contractions without Obvious Heart Diseases Determined by Standard 12\u2010Lead Electrocardiography Considering their Morphology"],"prefix":"10.1111","volume":"21","author":[{"given":"Daisuke","family":"Haruta","sequence":"first","affiliation":[{"name":"Department of Clinical Studies Radiation Effects Research Foundation  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masazumi","family":"Akahoshi","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Radiation Effects Research Foundation  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Hida","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Radiation Effects Research Foundation  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuko","family":"Sera","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Radiation Effects Research Foundation  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misa","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Radiation Effects Research Foundation  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Ichimaru","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Radiation Effects Research Foundation  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Departments of Statistics Radiation Effects Research Foundation  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuno","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Clinical Studies Radiation Effects Research Foundation  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waka","family":"Ohishi","sequence":"additional","affiliation":[{"name":"Clinical Studies Radiation Effects Research Foundation  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoki","family":"Fukae","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Maemura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.44.1.130"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908103210629"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199207233270403"},{"issue":"2","key":"e_1_2_7_5_1","first-page":"1","article-title":"Prognostic significance of PVCS and resting heart rate","volume":"12","author":"Engel G","year":"2007","journal-title":"ANE"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1996.tb03395.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.05.065"},{"key":"e_1_2_7_9_1","unstructured":"Atomic Bomb Casualty Commission.Research plan for joint ABCC\u2010NIH adult health study in Hiroshima and Nagasaki. 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