{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:31:56Z","timestamp":1769128316845,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The cause of ischemic stroke or transient ischemic attack (TIA) remains unclear after initial cardiac monitoring in approximately one\u2010third of patients. Randomized controlled trials (RCTs) showed that the prolonged cardiac monitoring of patients with cryptogenic stroke or TIA increased detection of atrial fibrillation (AF). We aimed to perform a meta\u2010analysis of all RCTs that evaluated the prolonged monitoring \u22657 days in patients with cryptogenic stroke or TIA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed, EMBASE, Cochrane CENTRAL, and relevant references for RCTs without language restriction (inception through December 2014) and performed meta\u2010analysis using random effects model. Detection of AF, use of anticoagulation at follow\u2010up, recurrent stroke or TIA, and mortality were major outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four RCTs with 1149 total patients were included in the meta\u2010analysis. Prolonged cardiac monitoring \u22657 days compared to shorter cardiac monitoring of \u226448 hours duration increased the detection of AF (\u226530 seconds duration) in patients after cryptogenic stroke or TIA (13.8% vs. 2.5%; odds ratio [OR], 6.4; 95% confidence interval [CI], 3.50\u201311.73; P &lt; 0.00001; I<jats:sup>2<\/jats:sup>, 0%]. It also increased the odds of AF detection of any duration (22.6% vs. 5.2%; 5.68[3.3\u20139.77]; P &lt; 0.00001; I<jats:sup>2<\/jats:sup>, 0%). The patients who underwent prolonged monitoring were more likely to be on anticoagulation at follow\u2010up (2.21[1.52\u20133.21]; P &lt; 0.0001; I<jats:sup>2<\/jats:sup>, 0%). No differences in recurrent stroke or TIA (0.78[0.40\u20131.55]; P = 0.48; I<jats:sup>2<\/jats:sup>, 0%) and mortality (1.33[0.29\u20136.00]; P = 0.71; I<jats:sup>2<\/jats:sup>, 0%] were observed between two strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prolonged cardiac monitoring improves detection of atrial fibrillation and anti\u2010coagulation use after cryptogenic stroke or TIA and therefore should be considered instead of shorter duration of cardiac monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12319","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T13:44:45Z","timestamp":1446471885000},"page":"382-388","source":"Crossref","is-referenced-by-count":22,"title":["Prolonged Cardiac Monitoring to Detect Atrial Fibrillation after Cryptogenic Stroke or Transient Ischemic Attack: A Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"21","author":[{"given":"Khagendra","family":"Dahal","sequence":"first","affiliation":[{"name":"Department of Medicine LRG Healthcare  Laconia NH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bikash","family":"Chapagain","sequence":"additional","affiliation":[{"name":"Department of Medicine LRG Healthcare  Laconia NH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raju","family":"Maharjan","sequence":"additional","affiliation":[{"name":"Division of Neurology Nanticoke Memorial Hospital  Seaford DE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Husam H.","family":"Farah","sequence":"additional","affiliation":[{"name":"Concord Cardiac Associates Dartmouth Hitchcock Medical Clinic  Concord NH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayesha","family":"Nazeer","sequence":"additional","affiliation":[{"name":"Concord Cardiac Associates Dartmouth Hitchcock Medical Clinic  Concord NH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Lootens","sequence":"additional","affiliation":[{"name":"Concord Cardiac Associates Dartmouth Hitchcock Medical Clinic  Concord NH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Concord Cardiac Associates Dartmouth Hitchcock Medical Clinic  Concord NH"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000442015.53336.12"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000166053.83476.4a"},{"key":"e_1_2_8_4_1","first-page":"840265","article-title":"Detection of paroxysmal atrial fibrillation in stroke\/tia patients","volume":"2013","author":"Khan M","year":"2013","journal-title":"Stroke Res 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